TY - JOUR AU - Steunebrink, Laura M. M. AU - Versteeg, Letty G. A. AU - Vonkeman, Harald E. AU - ten Klooster, Peter M. AU - Hoekstra, Monique AU - van de Laar, Mart A. F. J. PY - 2018 DA - 2018/01/17 TI - Radiographic progression in early rheumatoid arthritis patients following initial combination versus step-up treat-to-target therapy in daily clinical practice: results from the DREAM registry JO - BMC Rheumatology SP - 1 VL - 2 IS - 1 AB - Early and intensive targeted treatment with disease modifying anti-rheumatic drugs (DMARDs) has been shown to lead to substantial reductions in disease activity and radiograph damage in patients with early rheumatoid arthritis (RA). The aim of this quasi-experimental study was to compare the first-year radiographic progression rates between a treat-to-target (T2 T) strategy with initial combination therapy (strategy II, started in 2012) versus an initial step-up monotherapy (strategy I, started in 2006). SN - 2520-1026 UR - https://doi.org/10.1186/s41927-018-0009-8 DO - 10.1186/s41927-018-0009-8 ID - Steunebrink2018 ER -