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Table 3 Associations of DAS28-related variables with mental health and vitality or fatigue

From: Interpretation of DAS28 and its components in the assessment of inflammatory and non-inflammatory aspects of rheumatoid arthritis

A
  BSRBR antiTNF BSRBR-Control ERAN PPT study
SF36-Mental Health Score SF36-Mental Health Score SF36-Mental Health Score Beck Depression Index State Trait Anxiety Index
B (95% CI) p B (95% CI) p B (95% CI) p B (95% CI) p B (95% CI) p
TJC − 0.12 (− 0.14 to − 0.10) < 0.001 − 0.17 (− 0.21 to − 0.13) < 0.001 − 0.19 (− 0.26 to − 0.11) < 0.001 0.29 (0.01 to 0.57) 0.044 0.36 (0.08 to 0.63) 0.012
VAS-GH − 0.19 (− 0.21 to − 0.17) < 0.001 − 0.28 (− 0.32 to − 0.24) < 0.001 − 0.36 (− 0.43 to − 0.29) < 0.001 0.47 (0.21 to 0.73) 0.001 0.45 (0.19 to 0.70) 0.001
SJC −0.04 (− 0.06 to − 0.02) < 0.001 −0.05 (− 0.09 to − 0.01) 0.017 −0.01 (− 0.09 to 0.07) 0.735 −0.19 (− 0.48 to 0.09) 0.184 −0.22 (− 0.50 to 0.06) 0.125
ESR −0.07 (− 0.09 to − 0.05) < 0.001 −0.04 (− 0.08 to 0.00) 0.078 −0.11 (− 0.18 to − 0.03) 0.006 0.15 (− 0.16 to 0.46) 0.338 0.01 (− 0.30 to 0.31) 0.967
DAS28 −0.17 (− 0.19 to − 0.15) < 0.001 −0.21 (− 0.27 to − 0.17) < 0.001 −0.25 (− 0.32 to − 0.18) < 0.001 0.33 (0.02 to 0.64) 0.039 0.33 (0.03 to 0.63) 0.034
DAS28-P −0.10 (− 0.12 to − 0.08) < 0.001 −0.18 (− 0.22 to − 0.14) < 0.001 −0.23 (− 0.30 to − 0.15) < 0.001 0.37 (0.09 to 0.65) 0.012 0.41 (0.13 to 0.69) 0.005
Tender-swollen difference −0.09 (− 0.11 to − 0.07) < 0.001 −0.14 (− 0.18 to − 0.10) < 0.001 −0.18 (− 0.25 to − 0.10) < 0.001 0.31 (0.04 to 0.59) 0.027 0.39 (0.12 to 0.66) 0.006
Tender:swollen ratio −0.06 (− 0.08 to − 0.04) < 0.001 −0.10 (− 0.14 to − 0.06) < 0.001 −0.11 (− 0.22 to 0.01) 0.060 0.27 (− 0.08 to 0.61) 0.128 0.24 (− 0.08 to 0.57) 0.135
B
  BSRBR anti-TNF BSRBR control ERAN PPT study   
SF36-Vitality SF36-Vitality SF36-Vitality Fatigue Severity Scale   
B (95% CI) p B (95% CI) p B (95% CI) p B (95% CI) p   
TJC −0.13 (− 0.15 to − 0.11) < 0.001 − 0.17 (− 0.21 to − 0.13) < 0.001 − 0.27 (− 0.34 to − 0.20) < 0.001 0.30 (0.01 to 0.58) 0.042   
VAS-GH − 0.19 (− 0.21 to − 0.17) < 0.001 − 0.26 (− 0.30 to − 0.22) < 0.001 −0.36 (− 0.43 to − 0.29) < 0.001 0.57 (0.32 to 0.81) < 0.001   
SJC −0.05 (− 0.07 to − 0.03) < 0.001 −0.06 (− 0.10 to − 0.02) 0.002 −0.07 (− 0.14 to 0.01) 0.100 −0.11 (− 0.41 to 0.19) 0.473   
ESR −0.06 (− 0.08 to − 0.04) < 0.001 −0.09 (− 0.13 to − 0.05) 0.002 −0.14 (− 0.22 to − 0.07) < 0.001 0.16 (− 0.15 to 0.47) 0.304   
DAS28 − 0.18 (− 0.20 to − 0.15) < 0.001 −0.25 (− 0.29 to − 0.21) < 0.001 −0.33 (− 0.40 to − 0.26) < 0.001 0.43 (0.12 to 0.73) 0.007   
DAS28-P −0.11 (− 0.13 to − 0.09) < 0.001 −0.17 (− 0.21 to − 0.13) < 0.001 −0.28 (− 0.35 to − 0.21) < 0.001 0.38 (0.08 to 0.68) 0.013   
Tender-swollen difference −0.09 (− 0.11 to − 0.07) < 0.001 −0.13 (− 0.17 to − 0.09) < 0.001 − 0.22 (− 0.29 to − 0.15) < 0.001 0.31 (0.03 to 0.60) 0.033   
Tender:swollen ratio −0.07 (− 0.09 to − 0.05) < 0.001 −0.09 (− 0.13 to − 0.05) < 0.001 −0.17 (− 0.27 to − 0.08) 0.001 0.34 (− 0.05 to 0.74) 0.087   
  1. A: Mental health scores and B: Fatigue scores, with their associations with DAS28-related variables. Standardised linear regression coefficients, 95% confidence intervals and p values. TJC tender joint count, SJC swollen joint count, ESR erythrocyte sedimentation rate, VAS-GH visual analogue scale-general health. DAS28-P = proportion of DAS28-ESR attributable to patient-reported components. No corrects were performed for multiple comparisons. Statistically significant findings highlighted in bold