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Table 3 Associations of DAS28-related variables with mental health and vitality or fatigue

From: Interpretation of DAS28 and its components in the assessment of inflammatory and non-inflammatory aspects of rheumatoid arthritis

A

 

BSRBR antiTNF

BSRBR-Control

ERAN

PPT study

SF36-Mental Health Score

SF36-Mental Health Score

SF36-Mental Health Score

Beck Depression Index

State Trait Anxiety Index

B (95% CI)

p

B (95% CI)

p

B (95% CI)

p

B (95% CI)

p

B (95% CI)

p

TJC

− 0.12 (− 0.14 to − 0.10)

< 0.001

− 0.17 (− 0.21 to − 0.13)

< 0.001

− 0.19 (− 0.26 to − 0.11)

< 0.001

0.29 (0.01 to 0.57)

0.044

0.36 (0.08 to 0.63)

0.012

VAS-GH

− 0.19 (− 0.21 to − 0.17)

< 0.001

− 0.28 (− 0.32 to − 0.24)

< 0.001

− 0.36 (− 0.43 to − 0.29)

< 0.001

0.47 (0.21 to 0.73)

0.001

0.45 (0.19 to 0.70)

0.001

SJC

−0.04 (− 0.06 to − 0.02)

< 0.001

−0.05 (− 0.09 to − 0.01)

0.017

−0.01 (− 0.09 to 0.07)

0.735

−0.19 (− 0.48 to 0.09)

0.184

−0.22 (− 0.50 to 0.06)

0.125

ESR

−0.07 (− 0.09 to − 0.05)

< 0.001

−0.04 (− 0.08 to 0.00)

0.078

−0.11 (− 0.18 to − 0.03)

0.006

0.15 (− 0.16 to 0.46)

0.338

0.01 (− 0.30 to 0.31)

0.967

DAS28

−0.17 (− 0.19 to − 0.15)

< 0.001

−0.21 (− 0.27 to − 0.17)

< 0.001

−0.25 (− 0.32 to − 0.18)

< 0.001

0.33 (0.02 to 0.64)

0.039

0.33 (0.03 to 0.63)

0.034

DAS28-P

−0.10 (− 0.12 to − 0.08)

< 0.001

−0.18 (− 0.22 to − 0.14)

< 0.001

−0.23 (− 0.30 to − 0.15)

< 0.001

0.37 (0.09 to 0.65)

0.012

0.41 (0.13 to 0.69)

0.005

Tender-swollen difference

−0.09 (− 0.11 to − 0.07)

< 0.001

−0.14 (− 0.18 to − 0.10)

< 0.001

−0.18 (− 0.25 to − 0.10)

< 0.001

0.31 (0.04 to 0.59)

0.027

0.39 (0.12 to 0.66)

0.006

Tender:swollen ratio

−0.06 (− 0.08 to − 0.04)

< 0.001

−0.10 (− 0.14 to − 0.06)

< 0.001

−0.11 (− 0.22 to 0.01)

0.060

0.27 (− 0.08 to 0.61)

0.128

0.24 (− 0.08 to 0.57)

0.135

B

 

BSRBR anti-TNF

BSRBR control

ERAN

PPT study

  

SF36-Vitality

SF36-Vitality

SF36-Vitality

Fatigue Severity Scale

  

B (95% CI)

p

B (95% CI)

p

B (95% CI)

p

B (95% CI)

p

  

TJC

−0.13 (− 0.15 to − 0.11)

< 0.001

− 0.17 (− 0.21 to − 0.13)

< 0.001

− 0.27 (− 0.34 to − 0.20)

< 0.001

0.30 (0.01 to 0.58)

0.042

  

VAS-GH

− 0.19 (− 0.21 to − 0.17)

< 0.001

− 0.26 (− 0.30 to − 0.22)

< 0.001

−0.36 (− 0.43 to − 0.29)

< 0.001

0.57 (0.32 to 0.81)

< 0.001

  

SJC

−0.05 (− 0.07 to − 0.03)

< 0.001

−0.06 (− 0.10 to − 0.02)

0.002

−0.07 (− 0.14 to 0.01)

0.100

−0.11 (− 0.41 to 0.19)

0.473

  

ESR

−0.06 (− 0.08 to − 0.04)

< 0.001

−0.09 (− 0.13 to − 0.05)

0.002

−0.14 (− 0.22 to − 0.07)

< 0.001

0.16 (− 0.15 to 0.47)

0.304

  

DAS28

− 0.18 (− 0.20 to − 0.15)

< 0.001

−0.25 (− 0.29 to − 0.21)

< 0.001

−0.33 (− 0.40 to − 0.26)

< 0.001

0.43 (0.12 to 0.73)

0.007

  

DAS28-P

−0.11 (− 0.13 to − 0.09)

< 0.001

−0.17 (− 0.21 to − 0.13)

< 0.001

−0.28 (− 0.35 to − 0.21)

< 0.001

0.38 (0.08 to 0.68)

0.013

  

Tender-swollen difference

−0.09 (− 0.11 to − 0.07)

< 0.001

−0.13 (− 0.17 to − 0.09)

< 0.001

− 0.22 (− 0.29 to − 0.15)

< 0.001

0.31 (0.03 to 0.60)

0.033

  

Tender:swollen ratio

−0.07 (− 0.09 to − 0.05)

< 0.001

−0.09 (− 0.13 to − 0.05)

< 0.001

−0.17 (− 0.27 to − 0.08)

0.001

0.34 (− 0.05 to 0.74)

0.087

  
  1. A: Mental health scores and B: Fatigue scores, with their associations with DAS28-related variables. Standardised linear regression coefficients, 95% confidence intervals and p values. TJC tender joint count, SJC swollen joint count, ESR erythrocyte sedimentation rate, VAS-GH visual analogue scale-general health. DAS28-P = proportion of DAS28-ESR attributable to patient-reported components. No corrects were performed for multiple comparisons. Statistically significant findings highlighted in bold