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Table 4 Associations of DAS28-related variables with DAS28-ESR and CRP

From: Interpretation of DAS28 and its components in the assessment of inflammatory and non-inflammatory aspects of rheumatoid arthritis

 

BSRBR anti-TNF

BSRBR-Control

ERAN

B (95% CI)

p

B (95% CI)

p

B (95% CI)

p

DAS28

TJC

0.72 (0.71 to 0.73)

< 0.001

0.76 (0.74 to 0.78)

< 0.001

0.59 (0.55 to 0.62)

< 0.001

VAS-GH

0.49 (0.47 to 0.50)

< 0.001

0.62 (0.59 to 0.65)

< 0.001

0.46 (0.42 to 0.51)

< 0.001

SJC

0.56 (0.55 to 0.58)

< 0.001

0.60 (0.58 to 0.62)

< 0.001

0.48 (0.45 to 0.52)

< 0.001

ESR

0.49 (0.48 to 0.51)

< 0.001

0.53 (0.51 to 0.56)

< 0.001

0.41 (0.37 to 0.45)

< 0.001

DAS28

Not applicable

DAS28-P

0.19 (0.17 to 0.20)

< 0.001

0.29 (0.26 to 0.32)

< 0.001

0.24 (0.19 to 0.29)

< 0.001

Tender-swollen difference

0.25 (0.24 to 0.27)

< 0.001

0.36 (0.32 to 0.39)

< 0.001

0.15 (0.11 to 0.20)

< 0.001

Tender:swollen ratio

0.11 (0.09 to 0.12)

< 0.001

0.13 (0.10 to 0.16)

< 0.001

0.07 (0.02 to 0.12)

0.011

CRP

TJC

−0.02 (− 0.05 to 0.01)

0.161

0.09 (0.02 to 0.16)

0.010

0.17 (0.07 to 0.26)

< 0.001

VAS-GH

0.17 (0.14 to 0.20)

< 0.001

0.21 (0.13 to 0.28)

< 0.001

0.17 (0.08 to 0.26)

< 0.001

SJC

0.10 (0.07 to 0.13)

< 0.001

0.11 (0.05 to 0.17)

0.001

0.23 (0.13 to 0.32)

< 0.001

ESR

0.58 (0.55 to 0.60)

< 0.001

0.56 (0.51 to 0.62)

< 0.001

0.62 (0.55 to 0.69)

< 0.001

DAS28

0.36 (0.33 to 0.39)

< 0.001

0.47 (0.40 to 0.55)

< 0.001

0.45 (0.37 to 0.53)

< 0.001

DAS28-P

−0.31 (−0.34 to − 0.28)

< 0.001

− 0.28 (− 0.36 to − 0.20)

< 0.001

−0.20 (− 0.30 to − 0.11)

< 0.001

Tender-swollen difference

− 0.10 (− 0.13 to − 0.07)

< 0.001

−0.01 (− 0.08 to 0.06)

0.851

−0.03 (− 0.13 to 0.06)

0.487

Tender:swollen ratio

−0.11 (− 0.14 to − 0.08)

< 0.001

−0.08 (− 0.15 to − 0.01)

0.020

−0.08 (− 0.18 to 0.02)

0.104

  1. Linear regression of z-transformed variables. Regression coefficients (95% CI) and p values for associations with the inflammatory measures, DAS28 and CRP. CRP data were ln-transformed prior to regression analysis. TJC tender joint count, SJC swollen joint count, ESR erythrocyte sedimentation rate, VAS-GH visual analogue scale-general health. DAS28-P = proportion of DAS28-ESR attributable to patient-reported components. No corrects were performed for multiple comparisons. Statistically significant findings highlighted in bold