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Table 4 Associations of DAS28-related variables with DAS28-ESR and CRP

From: Interpretation of DAS28 and its components in the assessment of inflammatory and non-inflammatory aspects of rheumatoid arthritis

  BSRBR anti-TNF BSRBR-Control ERAN
B (95% CI) p B (95% CI) p B (95% CI) p
DAS28 TJC 0.72 (0.71 to 0.73) < 0.001 0.76 (0.74 to 0.78) < 0.001 0.59 (0.55 to 0.62) < 0.001
VAS-GH 0.49 (0.47 to 0.50) < 0.001 0.62 (0.59 to 0.65) < 0.001 0.46 (0.42 to 0.51) < 0.001
SJC 0.56 (0.55 to 0.58) < 0.001 0.60 (0.58 to 0.62) < 0.001 0.48 (0.45 to 0.52) < 0.001
ESR 0.49 (0.48 to 0.51) < 0.001 0.53 (0.51 to 0.56) < 0.001 0.41 (0.37 to 0.45) < 0.001
DAS28 Not applicable
DAS28-P 0.19 (0.17 to 0.20) < 0.001 0.29 (0.26 to 0.32) < 0.001 0.24 (0.19 to 0.29) < 0.001
Tender-swollen difference 0.25 (0.24 to 0.27) < 0.001 0.36 (0.32 to 0.39) < 0.001 0.15 (0.11 to 0.20) < 0.001
Tender:swollen ratio 0.11 (0.09 to 0.12) < 0.001 0.13 (0.10 to 0.16) < 0.001 0.07 (0.02 to 0.12) 0.011
CRP TJC −0.02 (− 0.05 to 0.01) 0.161 0.09 (0.02 to 0.16) 0.010 0.17 (0.07 to 0.26) < 0.001
VAS-GH 0.17 (0.14 to 0.20) < 0.001 0.21 (0.13 to 0.28) < 0.001 0.17 (0.08 to 0.26) < 0.001
SJC 0.10 (0.07 to 0.13) < 0.001 0.11 (0.05 to 0.17) 0.001 0.23 (0.13 to 0.32) < 0.001
ESR 0.58 (0.55 to 0.60) < 0.001 0.56 (0.51 to 0.62) < 0.001 0.62 (0.55 to 0.69) < 0.001
DAS28 0.36 (0.33 to 0.39) < 0.001 0.47 (0.40 to 0.55) < 0.001 0.45 (0.37 to 0.53) < 0.001
DAS28-P −0.31 (−0.34 to − 0.28) < 0.001 − 0.28 (− 0.36 to − 0.20) < 0.001 −0.20 (− 0.30 to − 0.11) < 0.001
Tender-swollen difference − 0.10 (− 0.13 to − 0.07) < 0.001 −0.01 (− 0.08 to 0.06) 0.851 −0.03 (− 0.13 to 0.06) 0.487
Tender:swollen ratio −0.11 (− 0.14 to − 0.08) < 0.001 −0.08 (− 0.15 to − 0.01) 0.020 −0.08 (− 0.18 to 0.02) 0.104
  1. Linear regression of z-transformed variables. Regression coefficients (95% CI) and p values for associations with the inflammatory measures, DAS28 and CRP. CRP data were ln-transformed prior to regression analysis. TJC tender joint count, SJC swollen joint count, ESR erythrocyte sedimentation rate, VAS-GH visual analogue scale-general health. DAS28-P = proportion of DAS28-ESR attributable to patient-reported components. No corrects were performed for multiple comparisons. Statistically significant findings highlighted in bold