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Table 5 Longitudinal associations of baseline DAS28-related variables with pain at follow up

From: Interpretation of DAS28 and its components in the assessment of inflammatory and non-inflammatory aspects of rheumatoid arthritis

  ERAN BSRBR anti-TNF BSRBR-Non-Biologic
Univariate Multivariable Univariate Multivariable Univariate Multivariable
B (95% CI) p B (95% CI) p B (95% CI) p B (95% CI) p B (95% CI) p B (95% CI) p
TJC −0.28 (− 0.34 to − 0.22) < 0.001 −0.09 (− 0.21 to 0.03) 0.131 −0.10 (− 0.12 to − 0.08) < 0.001 −0.02 (− 0.05 to 0.01) 0.264 −0.23 (− 0.26 to − 0.19) < 0.001 −0.10 (− 0.16 to − 0.05) < 0.001
SJC −0.09 (− 0.15 to − 0.03) 0.004 0.07 (− 0.01 to 0.16) 0.087 −0.02 (− 0.04 to 0.00) 0.090 0.03 (0.00 to 0.06) 0.029 −0.04 (− 0.08 to − 0.01) 0.019 −0.02 (− 0.07 to 0.03) 0.523
VAS-GH −0.36 (− 0.44 to − 0.29) < 0.001 −0.10 (− 0.23 to 0.02) 0.102 −0.14 (− 0.16 to − 0.12) < 0.001 −0.02 (− 0.05 to 0.01) 0.139 −0.29 (− 0.32 to − 0.26) < 0.001 −0.14 (− 0.20 to − 0.09) < 0.001
ESR −0.18 (− 0.25 to − 0.11) < 0.001 0.07 (− 0.07 to 0.20) 0.338 −0.07 (− 0.09 to − 0.05) < 0.001 0.01 (− 0.02 to 0.03) 0.695 −0.09 (− 0.13 to − 0.05) < 0.001 −0.04 (− 0.11 to 0.04) 0.349
DAS28 −0.31 (− 0.38 to − 0.23) < 0.001 −0.04 (− 0.17 to 0.09) 0.564 −0.14 (− 0.16 to − 0.12) < 0.001 −0.02 (− 0.04 to 0.01) 0.176 −0.25 (− 0.28 to − 0.21) < 0.001 −0.13 (− 0.19 to − 0.07) < 0.001
DAS28-P −0.26 (− 0.34 to − 0.19) < 0.001 −0.15 (− 0.27 to − 0.04) 0.007 −0.07 (− 0.09 to − 0.05) < 0.001 −0.02 (− 0.04 to 0.00) 0.089 −0.20 (− 0.24 to − 0.17) < 0.001 −0.14 (− 0.23 to − 0.05) 0.002
Tender-swollen difference −0.25 (− 0.32 to − 0.18) < 0.001 −0.14 (− 0.24 to − 0.04) 0.004 −0.08 (− 0.10 to − 0.06) < 0.001 −0.03 (− 0.05 to − 0.00) 0.019 −0.20 (− 0.23 to − 0.16) < 0.001 −0.11 (− 0.17 to − 0.05) 0.001
Tender:swollen ratio −0.17 (− 0.23 to − 0.10) < 0.001 −0.14 (− 0.21 to 0.06) < 0.001 −0.06 (− 0.08 to − 0.05) < 0.001 −0.03 (− 0.05 to − 0.01) 0.007 −0.15 (− 0.19 to − 0.11) < 0.001 −0.08 (− 0.14 to − 0.02) 0.016
  1. Generalised Estimating Equations for prediction of longitudinal pain (3/6 month and 1 year SF36-Bodily Pain). Univariate analyses show the associations between baseline DAS28-related variables and longitudinal pain with no adjustments. Multivariable analyses were similar, but with adjustments for baseline measures of pain, DAS28, CRP, seropositive, age, gender, BMI, smoking, SF36-physical function, SF36-vitality, SF36-mental health. TJC tender joint count, SJC swollen joint count, ESR erythrocyte sedimentation rate, VAS-GH visual analogue scale-general health. DAS28-P = proportion of DAS28-ESR attributable to patient-reported components. No corrects were performed for multiple comparisons. Statistically significant findings highlighted in bold