| |
Baseline
|
Week 24
|
Change from BL
|
|---|
|
MDA-R (n = 152)
|
MDA-NR (n = 322)
|
p
|
MDA-R (n = 152)
|
MDA-NR (n = 322)
|
MDA-R (n = 152)
|
MDA-NR (n = 322)
|
Diff.
|
p
|
|---|
|
SF-36 PCS
|
35.8 (9.4)
|
31.9 (8.9)
|
< 0.001
|
48.1 (7.1)
|
35.0 (9.6)
|
12.3 (9.0)
|
3.1 (7.8)
|
9.2 (8.2)
|
< 0.001
|
|
SF-36 MCS
|
49.3 (11.8)
|
46.8 (12.6)
|
0.047
|
53.7 (8.3)
|
50.5 (11.3)
|
4.4 (11.5)
|
3.8 (9.7)
|
0.7 (10.3)
|
0.51
|
|
EQ-5D-5 L HSI
|
0.62 (.20)
|
0.56 (.21)
|
0.003
|
0.82 (.14)
|
0.63 (0.17)
|
0.20 (0.20)
|
0.07 (0.20)
|
0.13 (0.20)
|
< 0.001
|
|
EQ-5D VAS
|
57.5 (21.0)
|
53.2 (20.3)
|
0.040
|
80.0 (16.6)
|
58.9 (20.3)
|
22.5 (21.7)
|
5.7 (22.4)
|
16.8 (22.2)
|
< 0.001
|
|
WPAI-SHP
|
|
% absenteeism
|
7.8 (20.4)a
|
6.2 (18.0)b
|
0.53
|
4.3 (15.1)a
|
8.2 (22.7)b
|
−3.5 (20.5)a
|
2.0 (25.7)b
|
−5.5 (23.9)
|
0.096
|
|
% presenteeism
|
33.8 (23.8)c
|
40.9 (25.6)d
|
0.061
|
6.8 (9.0)c
|
27.7 (22.0)d
|
−27.0 (23.3)c
|
−13.2 (27.0)d
|
−13.74 (25.67)
|
< 0.001
|
|
Overall work impairment
|
36.0 (25.7)c
|
42.2 (26.5)d
|
0.12
|
9.8 (13.4)c
|
30.2 (23.8)d
|
−26.2 (25.2)c
|
−12.1 (28.0)d
|
−14.1 (27.0)
|
< 0.001
|
|
% activity impairment non-work
|
42.2 (25.9)e
|
52.7 (24.9)f
|
<.001
|
10.0 (12.0)e
|
37.9 (24.9)f
|
−32.2 (26.9)e
|
−14.9 (28.4)f
|
−17.4 (27.9)
|
< 0.001
|
- Number of patients with data available where different from total n:an = 84; bn = 142; cn = 82; dn = 134; en = 152; fn = 321
- Abbreviations BL = baseline, Diff. = difference, EQ-5D-5 L = European Quality of Life 5 Dimension 5 Level Health Questionnaire, HSI = Health State Index, MCS = mental component summary, MDA = minimal disease activity, PCS = physical component summary, MDA-R = MDA-responder, MDA-NR = MDA-non-responder, SF-36 = 36-Item Short Form Health Survey, VAS = visual analog scale, WPAI-SHP = Work Productivity and Activity Impairment–Specific Health Problem
