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Fig. 3 | BMC Rheumatology

Fig. 3

From: In vitro and in vivo characterization of the JAK1 selectivity of upadacitinib (ABT-494)

Fig. 3

Rat in vivo selectivity of tofactinib and upadacitinib. a. Exposure response curves of tofacitinib on inhibition of paw swelling in rat AIA (red circles), CD3/CD16+/CD56+ NK cell inhibition (green triangles), and inhibition of Epo induced reticulocyte deployment (blue squares). Dotted gray vertical lines represent equivalent clinical exposures for 5 mg and 10 mg tofacitinib. b. Exposure response curves of upadacitinib on inhibition of paw swelling in rat AIA (red circles), CD3/CD16+/CD56+ NK cell inhibition (green triangles), and inhibition of Epo induced reticulocyte deployment (blue squares). Dotted gray vertical lines represent equivalent clinical exposures for 6 mg and 12 mg upadacitinib

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