Fig. 3

Rat in vivo selectivity of tofactinib and upadacitinib. a. Exposure response curves of tofacitinib on inhibition of paw swelling in rat AIA (red circles), CD3⁻/CD16⁺/CD56⁺ NK cell inhibition (green triangles), and inhibition of Epo induced reticulocyte deployment (blue squares). Dotted gray vertical lines represent equivalent clinical exposures for 5 mg and 10 mg tofacitinib. b. Exposure response curves of upadacitinib on inhibition of paw swelling in rat AIA (red circles), CD3⁻/CD16⁺/CD56⁺ NK cell inhibition (green triangles), and inhibition of Epo induced reticulocyte deployment (blue squares). Dotted gray vertical lines represent equivalent clinical exposures for 6 mg and 12 mg upadacitinib