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Table 3 Overview of themes related to the sub-analysis focused on modifying risk through lifestyle and preventive medicines

From: Perceptions of first-degree relatives of patients with rheumatoid arthritis about lifestyle modifications and pharmacological interventions to reduce the risk of rheumatoid arthritis development: a qualitative interview study

Modifying risk through lifestyle intervention
 • Positive view of lifestyle changes and/or continuing to engage with healthy living to reduce risk of developing RA
 • Healthy eating, diet and exercise as examples of life style changes
 • Being overweight considered a risk factor
 • Knowing risk is useful as it allows you to make life style changes as a preventive measure
 • Need for more information about effectiveness in order to make a decision about lifestyle changes
 • Perceived negative consequences of making life style changes
 • Unwilling to make lifestyle changes including smoking cessation, unless it is clear that there will be a significant reduction in risk
Willingness to take preventive medicines to modify risk
 • Uncertainty and worry about potential short term and long term side effects
 • Perceived need to consider pros and cons carefully
 • Weighing perceived uncertainty of developing RA against perceived certainty of side effects
 • Level of likelihood of getting RA affects consideration of preventive medicine
 • Negative opinion about taking medicines in general
 • Preference for making lifestyle changes over taking preventive medication
 • Recognition why medication might be used
 • Preference for starting medication only when first symptoms appear
 • Screening will put at risk individuals on alert for early symptoms
 • Perceived effectiveness of intervention (medication or lifestyle changes) makes a significant impact on acceptability