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Table 1 Clinical information of patients with aRA, iRA, and OA and of HL

From: A proteomic analysis of serum-derived exosomes in rheumatoid arthritis

  Active RA (n = 12) Inactive RA (n = 11) p Value (aRA vs. iRA) OA (n = 10) HL (n = 10)
Age (years), mean (range) 62.2 (31 to 79) 63.4 (41 to 80) 0.85 62.5 (41 to 74) 60.5 (41 to 82)
Sex, male/female 2/10 3/8 0.93 1/9 2/8
Disease duration (years), mean (range) 5.6 (0.25 to 20) 10.9 (0.25 to 38) 0.22 (−) (−)
ESR (mm/h), mean (range) 56.3 (16 to 100) 21.0 (2 to 41) < 0.01 (−) (−)
CRP (mg/L), mean (range) 3.19 (0.07 to 7.16) 0.14 (0.02 to 0.33) < 0.01 (−) (−)
MMP-3 (ng/mL), mean (range) 252.0 (18.8 to 602.4) 52.7 (10 to 121.5) < 0.01 (−) (−)
SJC, mean (range) 3.7 (1 to 8) 0 < 0.01 (−) (−)
TJC, mean (range) 6.3 (0 to 17) 0.8 (0 to 3) < 0.01 (−) (−)
RF positive (%) 83.3 72.7 0.56 (−) (−)
ACPA positive (%) 90.0 77.8 0.49 (−) (−)
DAS28-ESR, mean (range) 4.80 (4.21 to 5.72) 2.33 (0.51 to 3.02) < 0.01 (−) (−)
DAS28-CRP, mean (range) 3.84 (3.10 to 4.64) 1.49 (0.98 to 2.2) < 0.01 (−) (−)
Medication
 DMARDs (%) 75.0 90.9 0.34 (−) (−)
 Methotrexate (%) 50.0 81.8 0.11 (−) (−)
 Biologics (%) 8.0 18.1 0.51 (−) (−)
 Prednisolone (%) 41.7 0 0.01 (−) (−)
  1. ESR erythrocyte sedimentation rate, CRP C-reactive protein, MMP-3 matrix metalloproteinase-3, SJC swollen joint count, TJC tender joint count, RF rheumatoid factor, ACPA anti-cyclic citrullinated peptide antibody, DAS28-ESR disease activity score 28 joints using erythrocyte sedimentation rate, DAS28-CRP disease activity score 28 joints using C-reactive protein, DMARDs disease-modifying anti-rheumatic drugs