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Table 1 Demographics of SSc cases stratified by calendar time

From: Trends in incidence, mortality, and causes of death associated with systemic sclerosis in Denmark between 1995 and 2015: a nationwide cohort study

  1995–2001 2002–2008 2009–2015 p-value
N 830 887 1061  
Mean age 53.7 (15.6) 55.0 (15.3) 56.1 (15.5) 0.0008
Women 652 (79%) 687 (77%) 775 (73%) 0.01
Immigrants 56 (7%) 50 (6%) 86 (8%) 0.20
Cancer 48 (6%) 51 (6%) 101 (10%) 0.001
Chronic obstructive pulmonary disease 12 (1%) 21 (2%) 48 (5%) 0.0002
Treated hypertension (defined as at least 2 antihypertensive agents) 132 (16%) 264 (30%) 471 (44%) < 0.0001
Diabetes 25 (3%) 53 (6%) 61 (6%) 0.007
Upper gastrointestinal ulcer 47 (6%) 62 (7%) 83 (8%) 0.18
Renal disease 18 (2%) 18 (2%) 40 (4%) 0.03
Heart failure 24 (3%) 26 (3%) 34 (3%) 0.91
Prior acute myocardial infarction 28 (3%) 28 (3%) 30 (3%) 0.79
Peripheral artery disease 34 (4%) 34 (4%) 53 (5%) 0.42
Ischemic stroke 13 (2%) 23 (3%) 33 (3%) 0.10
  1. Footnote: Continuous and categorical variables are presented as mean (standard deviation) and as frequencies (%), respectively. All diagnoses were based on ICD-8 and ICD-10 codes, except for the diabetes mellitus (based on ‘Anatomical Therapeutical Chemical’ codes of antidiabetic medication) and the hypertension diagnosis, which was based on a validated algorithm with use of at least 2 antihypertensive agents [46], Additional file 1