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Table 3 Minor allele frequencies (MAFs) of COMT SNPs in subjects diagnosed with fibromyalgia (FM) compared with those of US populations from the 1000 Genomes Project (1000G-US)

From: Association of Catechol-O-methyltransferase single nucleotide polymorphisms, ethnicity, and sex in a large cohort of fibromyalgia patients

SNP/Population Minor Allele Frequency
1000G-US FM Group Direction Model β P-value
rs6269 (A > G) 0.36 0.39 − 0.03 2.40 × 10− 6
 African-American 0.34 0.38 − 0.04 0.023
 Caucasian 0.44 0.41 0.03 1.69 × 10− 4
 Hispanic 0.27 0.28   −0.01 0.580
Females 0.34 0.39 −0.05 1.69 × 10−12
African-American 0.29 0.38 −0.09 6.04 × 10−7
Caucasian 0.41 0.40   0.01 0.472
Hispanic 0.28 0.27   0.01 0.831
Males 0.39 0.40   −0.01 0.540
African-American 0.40 0.36   0.04 0.145
Caucasian 0.47 0.42 0.05 0.002
Hispanic 0.25 0.30   −0.05 0.347
rs4633 (C > T) 0.41 0.47 −0.06 1.08 × 10−22
 African-American 0.32 0.33   −0.01 0.583
 Caucasian 0.46 0.51 −0.05 3.04 × 10−8
 Hispanic 0.40 0.43   −0.03 0.348
Females 0.41 0.48 −0.07 7.16 × 10−20
African-American 0.33 0.33   0 0.838
Caucasian 0.48 0.52 −0.04 6.25 × 10−5
Hispanic 0.38 0.44   −0.06 0.064
Males 0.41 0.46 −0.05 8.18 × 10−5
African-American 0.31 0.32   −0.01 0.695
Caucasian 0.45 0.49 −0.04 0.009
Hispanic 0.42 0.39   0.03 0.601
rs4818 (C > G) 0.32 0.36 −0.04 2.15 × 10−9
 African-American 0.21 0.19   0.02 0.185
 Caucasian 0.44 0.40 0.04 1.69 × 10−5
 Hispanic 0.24 0.27   −0.03 0.245
Females 0.31 0.36 −0.05 1.17 × 10−9
African-American 0.23 0.19 0.04 0.024
Caucasian 0.41 0.40   0.01 0.356
Hispanic 0.25 0.26   −0.01 0.672
Males 0.33 0.36 −0.03 0.006
African-American 0.19 0.21   −0.02 0.573
Caucasian 0.47 0.41 0.06 1.19 × 10−4
Hispanic 0.23 0.30   −0.07 0.201
rs4680 (G > A) 0.39 0.47 −0.08 5.62 × 10−31
 African-American 0.27 0.31 −0.04 0.006
 Caucasian 0.46 0.51 −0.05 1.36 × 10−7
 Hispanic 0.40 0.44   −0.04 0.187
Females 0.40 0.48 −0.08 4.82 × 10−23
African-American 0.29 0.31   −0.02 0.145
Caucasian 0.48 0.52 −0.04 1.67 × 10−4
Hispanic 0.39 0.45   −0.06 0.088
Males 0.39 0.46 −0.07 4.35 × 10−8
African-American 0.25 0.32 −0.07 0.025
Caucasian 0.45 0.49 −0.04 0.012
Hispanic 0.41 0.41   0 0.988
  1. Comparisons that are statistically significant (p ≤ 0.05) are indicated with direction of increased or decreased frequency of MAF. Model β coefficients are the effect sizes. Differences between groups delineated by both sex and ethnicity are graphically shown in Fig. 2