Skip to main content

Table 3 Minor allele frequencies (MAFs) of COMT SNPs in subjects diagnosed with fibromyalgia (FM) compared with those of US populations from the 1000 Genomes Project (1000G-US)

From: Association of Catechol-O-methyltransferase single nucleotide polymorphisms, ethnicity, and sex in a large cohort of fibromyalgia patients

SNP/Population

Minor Allele Frequency

1000G-US

FM Group

Direction

Model β

P-value

rs6269 (A > G)

0.36

0.39

↑

− 0.03

2.40 × 10− 6

 African-American

0.34

0.38

↑

− 0.04

0.023

 Caucasian

0.44

0.41

↓

0.03

1.69 × 10− 4

 Hispanic

0.27

0.28

 

−0.01

0.580

Females

0.34

0.39

↑

−0.05

1.69 × 10−12

 African-American

0.29

0.38

↑

−0.09

6.04 × 10−7

 Caucasian

0.41

0.40

 

0.01

0.472

 Hispanic

0.28

0.27

 

0.01

0.831

Males

0.39

0.40

 

−0.01

0.540

 African-American

0.40

0.36

 

0.04

0.145

 Caucasian

0.47

0.42

↓

0.05

0.002

 Hispanic

0.25

0.30

 

−0.05

0.347

rs4633 (C > T)

0.41

0.47

↑

−0.06

1.08 × 10−22

 African-American

0.32

0.33

 

−0.01

0.583

 Caucasian

0.46

0.51

↑

−0.05

3.04 × 10−8

 Hispanic

0.40

0.43

 

−0.03

0.348

Females

0.41

0.48

↑

−0.07

7.16 × 10−20

 African-American

0.33

0.33

 

0

0.838

 Caucasian

0.48

0.52

↑

−0.04

6.25 × 10−5

 Hispanic

0.38

0.44

 

−0.06

0.064

Males

0.41

0.46

↑

−0.05

8.18 × 10−5

 African-American

0.31

0.32

 

−0.01

0.695

 Caucasian

0.45

0.49

↑

−0.04

0.009

 Hispanic

0.42

0.39

 

0.03

0.601

rs4818 (C > G)

0.32

0.36

↑

−0.04

2.15 × 10−9

 African-American

0.21

0.19

 

0.02

0.185

 Caucasian

0.44

0.40

↓

0.04

1.69 × 10−5

 Hispanic

0.24

0.27

 

−0.03

0.245

Females

0.31

0.36

↑

−0.05

1.17 × 10−9

 African-American

0.23

0.19

↓

0.04

0.024

 Caucasian

0.41

0.40

 

0.01

0.356

 Hispanic

0.25

0.26

 

−0.01

0.672

Males

0.33

0.36

↑

−0.03

0.006

 African-American

0.19

0.21

 

−0.02

0.573

 Caucasian

0.47

0.41

↓

0.06

1.19 × 10−4

 Hispanic

0.23

0.30

 

−0.07

0.201

rs4680 (G > A)

0.39

0.47

↑

−0.08

5.62 × 10−31

 African-American

0.27

0.31

↑

−0.04

0.006

 Caucasian

0.46

0.51

↑

−0.05

1.36 × 10−7

 Hispanic

0.40

0.44

 

−0.04

0.187

Females

0.40

0.48

↑

−0.08

4.82 × 10−23

 African-American

0.29

0.31

 

−0.02

0.145

 Caucasian

0.48

0.52

↑

−0.04

1.67 × 10−4

 Hispanic

0.39

0.45

 

−0.06

0.088

Males

0.39

0.46

↑

−0.07

4.35 × 10−8

 African-American

0.25

0.32

↑

−0.07

0.025

 Caucasian

0.45

0.49

↑

−0.04

0.012

 Hispanic

0.41

0.41

 

0

0.988

  1. Comparisons that are statistically significant (p ≤ 0.05) are indicated with direction of increased or decreased frequency of MAF. Model β coefficients are the effect sizes. Differences between groups delineated by both sex and ethnicity are graphically shown in Fig. 2