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Table 3 Disease progression from baseline to week 24

From: Tissue metabolite of type I collagen, C1M, and CRP predicts structural progression of rheumatoid arthritis

 

N

% progressors (delta mTSS > = 0.5 units per year)

% Rapid progressors (delta mTSS > = 5 units per year)

Delta sharp score

Delta erosion Score

Delta Joint space narrowing score

C1ML

145

25.5%

 

5.5%

 

0.23 (1.66)

 

0.01 (0.77)

 

0.20 (1.19)

 

C1MH

116

37.1%

0.045

13.8%

0.022

0.56 (3.16)

> 0.1

0.48 (2.49)

0.066

0.08 (1.07)

> 0.1

C1MV

51

43.1%

0.019

21.6%

0.0009

1.19 (4.31)

0.031

0.99 (3.47)

0.025

0.21 (1.28)

> 0.1

C3ML

133

31.6%

 

7.5%

 

0.43 (2.60)

 

0.22 (1.85)

 

0.20 (1.24)

 

C3MH

128

29.7%

> 0.1

10.9%

> 0.1

0.33 (2.59)

> 0.1

0.23 (1.69)

> 0.1

0.10 (1.02)

> 0.1

C3MV

59

28.8%

> 0.1

13.6%

> 0.1

0.33 (2.29)

> 0.1

0.36 (2.12)

> 0.1

−0.03 (1.09)

> 0.1

CRPL

145

26.9%

 

5.5%

 

0.18 (1.48)

 

−0.00 (0.78)

 

0.16 (1.02)

 

CRPH

116

35.3%

> 0.1

13.8%

0.022

0.63 (3.26)

> 0.1

0.51 (2.49)

0.058

0.13 (1.27)

> 0.1

CRPV

50

46.0%

0.013

24.2%

0.0006

1.40 (4.52)

0.025

1.06 (3.50)

0.0074

0.34 (1.70)

> 0.1

RFL

53

24.5%

 

3.8%

 

0.00 (0.95)

 

−0.06 (0.52)

 

0.06 (0.62)

 

RFH

208

32.2%

> 0.1

10.6%

> 0.1

0.48 (2.69)

> 0.1

0.29 (1.96)

> 0.1

0.17 (1.23)

> 0.1

RFV

104

34.6%

> 0.1

13.5%

0.059

0.44 (2.64)

> 0.1

0.20 (1.84)

> 0.1

0.22 (1.36)

> 0.1

  1. Data is shown as mean (SD) unless otherwise indicated. Chi-squared test or Mann-Whitney test was used as appropriate to compare C1M, C3M, CRP and RF subgroups (alpha = 0.1) and significance levels are indicated by exact p values