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Table 3 Disease progression from baseline to week 24

From: Tissue metabolite of type I collagen, C1M, and CRP predicts structural progression of rheumatoid arthritis

  N % progressors (delta mTSS > = 0.5 units per year) % Rapid progressors (delta mTSS > = 5 units per year) Delta sharp score Delta erosion Score Delta Joint space narrowing score
C1ML 145 25.5%   5.5%   0.23 (1.66)   0.01 (0.77)   0.20 (1.19)  
C1MH 116 37.1% 0.045 13.8% 0.022 0.56 (3.16) > 0.1 0.48 (2.49) 0.066 0.08 (1.07) > 0.1
C1MV 51 43.1% 0.019 21.6% 0.0009 1.19 (4.31) 0.031 0.99 (3.47) 0.025 0.21 (1.28) > 0.1
C3ML 133 31.6%   7.5%   0.43 (2.60)   0.22 (1.85)   0.20 (1.24)  
C3MH 128 29.7% > 0.1 10.9% > 0.1 0.33 (2.59) > 0.1 0.23 (1.69) > 0.1 0.10 (1.02) > 0.1
C3MV 59 28.8% > 0.1 13.6% > 0.1 0.33 (2.29) > 0.1 0.36 (2.12) > 0.1 −0.03 (1.09) > 0.1
CRPL 145 26.9%   5.5%   0.18 (1.48)   −0.00 (0.78)   0.16 (1.02)  
CRPH 116 35.3% > 0.1 13.8% 0.022 0.63 (3.26) > 0.1 0.51 (2.49) 0.058 0.13 (1.27) > 0.1
CRPV 50 46.0% 0.013 24.2% 0.0006 1.40 (4.52) 0.025 1.06 (3.50) 0.0074 0.34 (1.70) > 0.1
RFL 53 24.5%   3.8%   0.00 (0.95)   −0.06 (0.52)   0.06 (0.62)  
RFH 208 32.2% > 0.1 10.6% > 0.1 0.48 (2.69) > 0.1 0.29 (1.96) > 0.1 0.17 (1.23) > 0.1
RFV 104 34.6% > 0.1 13.5% 0.059 0.44 (2.64) > 0.1 0.20 (1.84) > 0.1 0.22 (1.36) > 0.1
  1. Data is shown as mean (SD) unless otherwise indicated. Chi-squared test or Mann-Whitney test was used as appropriate to compare C1M, C3M, CRP and RF subgroups (alpha = 0.1) and significance levels are indicated by exact p values