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Table 2 Spearman correlations between methods of reporting flares and other measures of disease activity. aadjusted for duration of follow-up for each participant. The area under the curve (AUC) for the measures of gout flare activity over the observation period was used in this analysis

From: The challenges of gout flare reporting: mapping flares during a randomized controlled trial

   Self-reported flare Gaffo CART-defined flare AUC pain-by-time plot
Time to first flarea Number of flares Number of months with ≥ 1 flare Days with flare Time to first flarea Number of flares Number of months with ≥ 1 flare Days with flare
Swollen joint count r −0.07 0.31 0.36 0.51 −0.20 0.37 0.42 0.41 0.50
P 0.49 0.001 < 0.001 < 0.001 0.04 < 0.001 < 0.001 < 0.001 < 0.001
Tender joint count r −0.18 0.34 0.35 0.49 −0.20 0.29 0.35 0.33 0.44
P 0.07 < 0.001 < 0.001 < 0.001 0.04 0.002 < 0.001 < 0.001 < 0.001
C-reactive protein r 0.00 0.10 0.21 0.30 −0.31 0.24 0.28 0.32 0.34
P 0.99 0.30 0.03 0.002 0.001 0.01 0.003 0.001 0.001
Patient global assessment r −0.19 0.44 0.45 0.62 −0.35 0.54 0.60 0.61 0.67
P 0.04 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001
Physician global assessment r −0.20 0.44 0.45 0.62 −0.35 0.54 0.60 0.60 0.67
P 0.04 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001