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Table 3 Spearman correlations between time-dependent variables (days with self reported flare and AUC pain-by-time plot) with other measures of disease activity depending on gout clinical characteristics at baseline. The area under the curve (AUC) for the measures of gout flare activity over the observation period was used in this analysis

From: The challenges of gout flare reporting: mapping flares during a randomized controlled trial

  No tophi, n = 77 Tophi, n = 43 Disease duration ≤ 12.5 yearsa, n = 63 Disease duration > 12.5 years, n = 57 Three or fewer flares in prior 4 months, n = 64 More than three flares in prior 4 monthsb, n = 56 No anti-inflammatory medications n = 38 Anti-inflammatory medications n = 82
Days with self-reported flare
 Swollen joint count r 0.49 0.45 0.63 0.38 0.37 0.66 −0.23 0.73
P < 0.001 0.005 < 0.001 0.004 0.004 < 0.001 0.20 < 0.001
 Tender joint count r 0.42 0.65 0.56 0.43 0.46 0.52 −0.01 0.63
P < 0.001 < 0.001 < 0.001 0.001 < 0.001 < 0.001 0.98 < 0.001
 C-reactive protein r 0.19 0.38 0.16 0.44 0.13 0.48 0.28 0.27
P 0.11 0.02 0.25 0.001 0.34 < 0.001 0.12 0.02
 Patient global assessment r 0.67 0.41 0.61 0.61 0.53 0.64 0.57 0.63
P < 0.001 0.01 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001
 Physician global assessment r 0.66 0.42 0.62 0.61 0.52 0.65 0.59 0.63
P < 0.001 0.009 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001
AUC pain-by-time plot
 Swollen joint count r 0.48 0.47 0.68 0.30 0.41 0.55 −0.19 0.73
P < 0.001 0.004 < 0.001 0.03 0.001 < 0.001 0.28 < 0.001
 Tender joint count r 0.35 0.60 0.50 0.40 0.36 0.54 0.06 0.51
P 0.002 < 0.001 < 0.001 0.002 0.005 < 0.001 0.73 < 0.001
 C-reactive protein r 0.23 0.54 0.26 0.42 0.21 0.52 0.20 0.37
P 0.06 < 0.001 0.06 0.001 0.11 < 0.001 0.28 0.001
 Patient global assessment r 0.72 0.46 0.67 0.67 0.58 0.65 0.72 0.64
P < 0.001 0.004 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001
 Physician global assessment r 0.72 0.45 0.67 0.65 0.58 0.65 0.72 0.64
P < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 < 0.001
  1. aMedian disease duration was 12.5 years. bMedian number of flares in prior 4 months was 3