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Table 5 Proposed Mechanism of Adverse Reactions

From: Adverse infusion reactions to rituximab in systemic lupus erythematosus: a retrospective analysis

  Immediate Hypersensitivity Delayed Hypersensitivity Total
Cycle Number Unlikely immune mediated Likely cytokine release Likely immunoglobulin mediated Bone pain Early (24–48 h) Late (> 48 h)
1 1 2 3 2 1 1 10
2 2 3 1    3 9
3   2 1    1 4
4        
5        
6 1       1
Total 4 7 5 2 1 5 24
  1. Based on review of the clinical description of the reaction by Clinical Allergist
  2. 4 reactions were excluded from this analysis; 1 death as likely CYC induced ARDS, and 3 due to lack of data