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Table 3 Patient outcomes by change in HAQ-DI between month 0 and month 6

From: Use of a “critical difference” statistical criterion improves the predictive utility of the Health Assessment Questionnaire-Disability Index score in patients with rheumatoid arthritis

 HAQ-DI-dcrit improvement (≥0.68) at month 6 (n = 639)Small improvement (≥0.22 to < 0.68) at month 6 (n = 961)No improvement (< 0.22) at month 6 (n = 1295)
OutcomeMonth 12Month 24Month 12Month 24Month 12Month 24
n536385782553928638
Mean values (standard deviation)
DAS282.90 (1.26)2.86 (1.25)3.48 (1.33)3.30 (1.38)3.83 (1.31)3.62 (1.27)
Paina3.1 (2.4)3.1 (2.5)4.1 (2.4)3.8 (2.4)4.9 (2.3)4.5 (2.3)
Fatiguea3.3 (2.6)3.4 (2.6)4.2 (2.6)3.8 (2.7)4.9 (2.6)4.5 (2.6)
PGAa3.1 (2.3)3.3 (2.5)4.2 (2.3)3.8 (2.3)4.9 (2.3)4.5 (2.2)
Tender joint count1.9 (3.3)1.9 (3.3)3.6 (4.9)3.3 (5.0)4.5 (5.9)3.8 (5.3)
Swollen joint count1.3 (2.3)1.2 (2.5)2.3 (3.6)1.9 (3.3)2.5 (4.0)2.0 (3.5)
% of patients
HAQ-DI remission (≤0.5)52.254.224.726.28.7111.1
DAS28 remission (≤2.6)46.648.725.234.817.524.4
DAS28-dcrit response (≥1.8 from baseline)66.068.450.153.532.136.2
Pain-dcrit response (≥3 from baseline)67.567.945.247.627.231.3
Fatigue-dcrit response (≥3 from baseline)59.751.938.242.523.427.9
PGA-dcrit response (≥3 from baseline)67.563.943.748.728.731.4
  1. Abbreviations: DAS28 Disease Activity Score-28 joints, dcrit critical difference for change beyond random variation, HAQ-DI Health Assessment Questionnaire-Disability Index, PGA patient global assessment
  2. Complete data were not available for all patients
  3. aMeasured on a categorical scale ranging from 0 (best) to 10 (worst)