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Table 3 Comparison of parameters between 52 weeks-remission and 52 weeks-non remission groups at 12 weeks of TCZ therapy

From: Serum levels of reactive oxygen metabolites at 12 weeks during tocilizumab therapy are predictive of 52 weeks-disease activity score-remission in patients with rheumatoid arthritis

 

DAS

CDAI

R

NR

p

R

NR

p

ROM

278 ± 62.4

348 ± 98.4

0.008**

276 ± 58.0

308 ± 88.4

0.158

CRP

0.150 ± 0.400

1.68 ± 0.150

0.202

0.219 ± 0.765

0.724 ± 2.28

0.329

MMP-3

120 ± 84.7

119 ± 107

0.964

105 ± 47.3

134 ± 113

0.249

TJC

2.6 ± 4.1

4.7 ± 6.6

0.23

1.7 ± 3.6

4.2 ± 5.5

0.082

SJC

1.0 ± 2.2

1.6 ± 2.7

0.505

0.41 ± 0.9

1.8 ± 3.0

0.037*

HAQ

0.500 ± 0.579

0.800 ± 0.806

0.194

0.285 ± 0.338

0.812 ± 0.739

0.004**

  1. TCZ, tocilizumab; ROM, reactive oxygen metabolites; CRP, C-reactive protein; MMP-3, matrix metalloproteinase-3; TJC, tender joint count; SJC, swollen joint count; HAQ, health assessment questionnaire; DAS, disease activity score; CDAI, clinical disease activity index; R, remission; NR, non-remission. Values are expressed as mean ± SD. Significantly different between remission and non-remission groups, *p < 0.05, **p < 0.01