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Table. 2 Characteristics indicated by severity of change during DAS28 Flares

From: Disease activity flares and pain flares in an early rheumatoid arthritis inception cohort; characteristics, antecedents and sequelae

 All DAS28 Flares (n = 323)Moderate DAS28 Flare (n = 171)Self-report DAS28 Flare (n = 31)Observed DAS28 Flare (n = 34)pPairwise comparison between DAS28 Flare subgroups (p value)
M vs SRM vs OSR vs O
DAS281.7 (0.8)1.5 (0.7)2.3 (1.0)2.3 (0.7)< 0.001< 0.001< 0.0010.999
ESR9 (15)11 (16)13 (17)7 (12)0.2060.9990.5100.247
SJC3 (4)2 (3)4 (4)6 (6)< 0.0010.011< 0.0010.100
TJC5 (6)3 (3)6 (5)15 (5)< 0.001< 0.001< 0.001< 0.001
VAS21 (25)19 (21)55 (23)14 (23)< 0.001< 0.0010.801< 0.001
BP5 (10)3 (9)16 (12)2 (9)< 0.001< 0.0010.999< 0.001
VT3 (9)2 (8)18 (7)−1 (8)< 0.001< 0.0010.478< 0.001
MH3 (9)1 (8)14 (10)0 (9)< 0.001< 0.0010.999< 0.001
  1. Data are mean (sd) changes at the time of DAS28 Flare categorisation from the preceding assessment. Change during Flare is rescaled to indicate worsening with positive values for all measures (including SF36 subscales). Significant heterogeneity between latent classes was recorded after univariate ANOVA. Pairwise comparisons with p values (shown after Bonferonni corrections) were performed. MvSR = Moderate vs Self-report. MvO = Moderate vs Observed. SRvO=Self-report vs Observed. Bold indicates the values for the most severely affected subgroups when heterogeneity was detected
  2. ESR erythrocyte sedimentation rate, SJC swollen joint count, TJC tender joint count, VAS visual analogue scale for general health, BP SF36-Bodily Pain, VT SF36-Vitality, MH SF36-Mental Health. Changes in SF36 scores = 10 indicate one standard deviation predicted for the UK population