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Table 1 Characteristics of patients and controls

From: Use of antidepressants and benzodiazepine-related hypnotics before and after initiation of TNF-α inhibitors or non-biological systemic treatment in patients with rheumatoid arthritis, psoriatic arthritis or ankylosing spondylitis

 

TNF

 

NBS

 

N

6256

 

13,241

 

Women, %

61.6

 

60.5

 

 Age mean (SD)

52.0

(14.5)

56.1

(16.3)

Women

53.1

(14.5)

56.0

(16.6)

Men

50.3

(14.3)

56.3

(15.8)

Antidepressants

 Baseline rate, %

11.8

 

10.9

 

 Controls, %

6.6

 

7.6

 

 Difference (95% c.i.)

5.2

(4.35–5.99)

3.3

(2.77–3.87)

Benzodiazepine-related hypnotics

 Baseline rate, %

10.7

 

10.4

 

 Controls, %

6.6

 

7.6

 

 Difference (95% c.i.)

4.1

3.34–4.92

2.8

2.25–3.33

Number of drugs (substances, 3 months before index)

 Patients

  mean (SD)

6.9

(4.2)

6.5

(3.8)

 Controls

  mean (SD)

2.0

(3.0)

2.3

(3.1)

Number of outpatient visits (past 12 months)

 Patients

  mean (SD)

5.6

(4.1)

3.0

(3.7)

 Controls

  mean (SD)

0.8

(2.3)

0.8

(2.4)

Proportion, at least one hospitalization (past 12 months)

 Patients, %

20

 

21

 

 Controls, %

9

 

10

 
  1. TNF TNF-α inhibitors, NBS Non-biologic systemic