Fig. 6

Differential expression analysis of proteins released into BEX conditioned media. Conditioned media from days 10, 14, 19 and 21 was analyzed and relatively quantified by mass spectrometry. AUC was calculated as an indication of total signal, and untreated and IL-17A treatment group AUC values were compared using ROTS statistical test with FDR < 0.05 considered significant. Only proteins with relative abundance values in both treatment groups were considered. a a volcano plot showing the relationship between fold changes and p-values, and b a heatmap with hierarchical clustering showing the expression levels of the 16 differentially expressed proteins as colors