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Fig. 2 | BMC Rheumatology

Fig. 2

From: MicroRNA and mRNA profiling in the idiopathic inflammatory myopathies

Fig. 2

Top ten canonical pathways enriched for dysregulation in anti-Jo1 positive samples compared to controls PM Polymyositis, DM Dermatomyositis, IBM Inclusion Body Myositis, Anti-Jo1 Anti-Jo1 autoantibody positive subset of PM and DM, Th T-helper cell, IRF Interferon regulatory factor, NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells, iNOS Inducible nitric oxide synthase. Data generated using QIAGEN’s Ingenuity Pathway Analysis ‘Canonical Pathways’ tool on differential expression data from RNA sequencing of whole blood from 7 PM, 7 DM, 5 IBM and 5 non-myositis controls. The dashed line indicates the significance threshold of –log p-value > 1.3 (p-value < 0.05) for over-representation of dysregulated genes in the pathway

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