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Table 3 Themes emerging from the narrative analysis of DMARDs calls

From: Real-world questions and concerns about disease-modifying antirheumatic drugs (DMARDs): a retrospective analysis of questions to a medicine call center

ThemesAll DMARDs
% (n = 681)
cDMARDs
% (n = 591)
(%)
bDMARDs
% (n=90)
(%)
Major themes & subthemes
1. Concern about medication safety26.928.420.8
1.1. Clarification on potential side effect of a specified DMARD
“Will methotrexate cause hair loss?”
20.221.016.8
1.2. Information on the general safety of a specified DMARD
“What are the side effects of adalimumab?”
4.04.32.4
1.3. Reassurance on the use of a specified DMARD
“What are the risks of taking methotrexate as I am worried about taking it after the things I read on the internet?”
2.73.11.6
2. Seeking information on potential interactions with a specified DMARD22.425.68.0
2.1. Seeking information on potential interactions of medicines with a specified DMARD
“Can hydroxychloroquine be taken with diclofenac?”
16.919.26.4
2.2. Seeking information on potential interactions of complementary medicines with a specified DMARD
“Can I take St john’s wort if I am on Mabthera (rituximab)?”
3.54.10.8
2.3. Lifestyle while on a specified DMARD
“Would there be an interaction between methotrexate and some alcohol I had at Christmas?”
1.61.90.0
2.4. Seeking information on potential interactions of a specified DMARD with food
“Any interactions between food and Humira (adalimumab) injection?”
0.40.40.8
3. Seeking a therapeutic strategy13.014.74.0
3.1. Seeking a therapeutic strategy regarding the timing, dose, and administration of a specified DMARD
“Do I inject methotrexate intramuscularly or subcutaneously?”
7.58.03.2
3.2. Seeking a therapeutic strategy regarding dosing and timing of concomitant medicines to DMARD therapy
“What is the normal dose of folic acid when I am also on methotrexate 20 mg per week?”
1.01.00.0
3.3. Seeking a therapeutic strategy for managing withdrawal and/or reintroduction of a specified DMARD
“Can he stop methotrexate suddenly or does he have to do so gradually?”
2.63.20.0
3.4. Seeking a therapeutic strategy regarding the management of an adverse event and/or the continuation of DMARD therapy in case of an occurred adverse event
“What can I do if I’ve experienced hives and irritation since starting adalimumab?”
1.51.60.8
3.5. Seeking a therapeutic strategy to manage a DMARD therapy before and/or after a procedure or an elective surgery
“When should I cease meloxicam and sulfasalazine before surgery?”
0.70.90.0
4. Seeking information on a specified DMARD10.14.933.6
4.1. Seeking general information on a specified DMARD
“Can you please provide me with information on hydroxychloroquine?”
4.43.68.0
4.2. Seeking information on a specified DMARD in response to media
“Disabled friend in his 70s saw a TV documentary on a new drug for arthritis- what is it?”
2.30.212.0
4.3. Seeking information on the availability, cost, and logistics to access a specified DMARD
“How can I obtain an emergency supply of Enbrel (etanercept) when my specialist is away?”
1.91.15.6
4.4. Seeking information on the restrictions and requirements to obtain subsidized DMARD
“Why can’t my 16-year-old nephew get Humira (adalimumab) on the PBS?”
1.50.28.0
Minor themes
1. Quantifying the benefit and harm of a specified DMARD
“What are the risks verse benefits of taking methotrexate for the treatment of psoriasis?”
7.57.57.2
2. Concern on the impact of a DMARD on reproductive health
“Could any of my partner’s medicines cause abnormalities in my child: prednisone, methotrexate, leflunomide?”
4.34.72.4
3. Storage, handling and stability of a specified DMARD
“How do I know if Humira (adalimumab) is okay if it was left out of the fridge for over 24 h?”
1.508.0
4. Concern about the safety of contact with a DMARD user
“Can my daughter have contact with pregnant women or children if she is on methotrexate?”
1.01.30.2