TY - JOUR AU - Maruyama, Hiroshi AU - Hirayama, Kouichi AU - Yamashita, Marina AU - Ohgi, Kentaro AU - Tsujimoto, Ryuji AU - Takayasu, Mamiko AU - Shimohata, Homare AU - Kobayashi, Masaki PY - 2020 DA - 2020/08/25 TI - Serum 20S proteasome levels are associated with disease activity in MPO-ANCA-associated microscopic polyangiitis JO - BMC Rheumatology SP - 36 VL - 4 IS - 1 AB - Proteasomes are found in both the cell nucleus and cytoplasm and play a major role in the ubiquitin-dependent and -independent non-lysosomal pathways of intracellular protein degradation. Proteasomes are also involved in the turnover of various regulatory proteins, antigen processing, cell differentiation, and apoptosis. To determine the diagnostic value of serum proteasome in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), we investigated patients with AAV at various stages of the disease. SN - 2520-1026 UR - https://doi.org/10.1186/s41927-020-00137-4 DO - 10.1186/s41927-020-00137-4 ID - Maruyama2020 ER -