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Fig. 1 | BMC Rheumatology

Fig. 1

From: Pembrolizumab on pre-existing inclusion body myositis: a case report

Fig. 1

Clinical course and histopathologic features. a Time course of serum CK levels. bg Histopathological findings of biopsy of the biceps muscle. b Gomori trichrome staining showing rimmed vacuoles. c, d Serial sections of immunohistochemistry for CD8 and MHC class I. c Endomysial CD8-positive cells surrounding and invading non-necrotic fibers (arrow). d Diffuse expression of MHC class I antigen in non-necrotic fibers. e Immunohistochemistry for p62 showing p62-positive cytoplasmic inclusions. f, g Serial sections of immunohistochemistry for PD-1 and PD-L1. f Endomysial PD-1-positive cells surrounding and invading non-necrotic fibers (arrows). g PD-L1-positive cells and PD-L1 overexpression in the non-necrotic fibers surrounded by PD-1-positive cells. Bars = 50 μm

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