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Fig. 2 | BMC Rheumatology

Fig. 2

From: Serum protein biomarkers for juvenile dermatomyositis: a pilot study

Fig. 2

Comparison of SomaScan® serum proteome profiles of untreated JDM and healthy controls. The upper panel is a volcano plot showing significance versus log2 fold change in protein levels in U-JDM patients compared to healthy controls. SomaScan® RFU values were log2 transformed and plotted as log2 fold change for the 1305 proteins in U-JDM patients (n = 8) relative to healthy controls (n = 12). Green dots represent elevated proteins and red dots decreased proteins in sera samples of JDM patients relative to controls. The dashed blue line indicates the p value cutoff < 0.001 after adjustment for multiple testing. The most statistically significantly altered proteins are labeled from those decreased and increased in U-JDM vs HC are labeled. The lower panel shows a bar chart depicting the general biological function groups of some differentially altered proteins in blood of JDM patients relative to controls; the direction of the bars indicates whether this group was differentially increased (right) or decreased (left). Frequencies are provided within the bars

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