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Table 2 Biomarkers investigated with ELISA in sera samples of female U-JDM versus age matched female controls

From: Serum protein biomarkers for juvenile dermatomyositis: a pilot study

8 untreated JDM vs 17 healthy control females
Biomarker Name, (Accession Number) SomaScan® assay MSD ELISA assay Confirm (Yes/No) Previously reported by others or novel
Fold Change Adjusted P-value (direction) Fold Change Adjusted P-value
CXCL11
(I-TAC)
(O14625)
13.7 <  0.001 (↑) 6.75 < 0.001 (↑) Yes [31]
IL-17B (Q9UHF5) −2.1 < 0.001 (↓) −2.4 < 0.001 (↓) Yes Novel
IL-17D (Q8TAD2) −1.28 0.002 (↓) −1.4 0.128 (↓) No [32]
IL-22 (Q9GZX6) 62 < 0.001(↑) 4.27 < 0.001 (↑) Yes Novel
CXCL10 (IP-10)
(P02778)
11.3 < 0.001 (↑) 16.4 < 0.001 (↑) Yes [33]
MCP-1 (P13500) 2.1 < 0.001 (↑) 3.11 0.001 (↑) Yes [34]
ANGPT2 (O15123) 3.8 < 0.001 (↑) 2.6 < 0.001 (↑) Yes Novel
MIF (P14174) 2.38 < 0.001 (↑) 1.2 0.467 (↑) No [35]
IL-23 (P29460, Q9NPF7) 2.22 0.001 (↑) −1.1 0.306 (↓) No Novel
  1. C-X-C motif chemokine 11 (I-TAC or CXCL11), Interleukin-17B (IL-17B), Interleukin-17D (IL-17D), Interleukin-22 (IL-22), C-X-C motif chemokine 10 (IP-10 or CXCL10), C-C motif chemokine 2 (CCL2 or MCP-1), Angiopoietin-2 (ANG-2 or ANGPT2), Macrophage migration inhibitory factor (MIF) and Interleukin-23 (IL-23).