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Table 2 Ultrasound, MBDA Score, and RA Disease Activity Measures Over 12 Weeks

From: Ultrasound and multi-biomarker disease activity score for assessing and predicting clinical response to tofacitinib treatment in patients with rheumatoid arthritis

Measure (range/unit) Baseline mean (SD)
N = 25
2 weeks mean (SD)
N = 25
12 weeks mean (SD)
N = 24
p-value SRM
PDUS (0–102) 28.7 (17.8) 19.5 (15.4) 12.2 (10.6) < 0.0001 1.18
GSUS (0–102) 48.4 (16.5) 44.9 (16.4) 37.9 (15.3) < 0.0001 0.90
mUS7 PDUS (0–36) 10.2 (6.5) 7.0 (5.2) 4.1 (4.0) < 0.0001 1.10
mUS7 GSUS (0–24) 18.0 (7.1) 15.7 (7.1) 12.9 (5.9) < 0.0001 0.95
MBDA Score (1–100) 50.6 (17.5) 41.0 (15.1) 39.6 (15.3) < 0.0001 0.73
CDAI (0–76) 39.9 (13.2) 28.6 (13.2) 21.6 (13.0) < 0.0001 1.73
DAS28/ESR (0- ~ 9.1) 6.3 (1.2) 5.2 (1.3) 4.6 (1.4) < 0.0001 1.71
TJC28 (0–28) 12.6 (6.5) 8.7 (6.5) 6.3 (5.8) < 0.0001 1.12
SJC28 (0–28) 13.0 (6.4) 9.3 (6.1) 7.1 (5.4) < 0.0001 1.26
Physician Global (0–10) 6.8 (2.0) 5.4 (1.6) 4.2 (1.6) < 0.0001 1.53
Patient Global (0–10) 7.0 (1.9) 4.9 (2.1) 3.5 (2.6) < 0.0001 1.31
ESR (mm/hr) 39.2 (27.4) 31.6 (22.0) 27.6 (20.3) 0.003 0.55
hsCRP (mg/L) 16.7 (20.8) 6.7 (7.4) 8.1 (16.7) 0.02 0.36
HAQ-DI (0–3) 1.4 (0.7) 1.0 (0.6) 0.7 (0.6) < 0.0001 0.83
  1. PDUS Power doppler ultrasound, GSUS Gray scale ultrasound, mUS7 Modified ultrasound 7, MBDA Multi-biomarker disease activity, CDAI Clinical disease activity index, DAS28/ESR Disease activity score, erythrocyte sedimentation rate, TJC Tender joint count, SJC Swollen joint count, hsCRP High-sensitivity C-reactive protein, HAQ-DI Health assessment questionnaire-disability Index, SRM Standardized Response Means. P-values represent the significance of the effect of time in repeated measures ANOVA models