Table 2 Ultrasound, MBDA Score, and RA Disease Activity Measures Over 12 Weeks
Measure (range/unit) | Baseline mean (SD) N = 25 | 2 weeks mean (SD) N = 25 | 12 weeks mean (SD) N = 24 | p-value | SRM |
|---|---|---|---|---|---|
PDUS (0–102) | 28.7 (17.8) | 19.5 (15.4) | 12.2 (10.6) | < 0.0001 | 1.18 |
GSUS (0–102) | 48.4 (16.5) | 44.9 (16.4) | 37.9 (15.3) | < 0.0001 | 0.90 |
mUS7 PDUS (0–36) | 10.2 (6.5) | 7.0 (5.2) | 4.1 (4.0) | < 0.0001 | 1.10 |
mUS7 GSUS (0–24) | 18.0 (7.1) | 15.7 (7.1) | 12.9 (5.9) | < 0.0001 | 0.95 |
MBDA Score (1–100) | 50.6 (17.5) | 41.0 (15.1) | 39.6 (15.3) | < 0.0001 | 0.73 |
CDAI (0–76) | 39.9 (13.2) | 28.6 (13.2) | 21.6 (13.0) | < 0.0001 | 1.73 |
DAS28/ESR (0- ~ 9.1) | 6.3 (1.2) | 5.2 (1.3) | 4.6 (1.4) | < 0.0001 | 1.71 |
TJC28 (0–28) | 12.6 (6.5) | 8.7 (6.5) | 6.3 (5.8) | < 0.0001 | 1.12 |
SJC28 (0–28) | 13.0 (6.4) | 9.3 (6.1) | 7.1 (5.4) | < 0.0001 | 1.26 |
Physician Global (0–10) | 6.8 (2.0) | 5.4 (1.6) | 4.2 (1.6) | < 0.0001 | 1.53 |
Patient Global (0–10) | 7.0 (1.9) | 4.9 (2.1) | 3.5 (2.6) | < 0.0001 | 1.31 |
ESR (mm/hr) | 39.2 (27.4) | 31.6 (22.0) | 27.6 (20.3) | 0.003 | 0.55 |
hsCRP (mg/L) | 16.7 (20.8) | 6.7 (7.4) | 8.1 (16.7) | 0.02 | 0.36 |
HAQ-DI (0–3) | 1.4 (0.7) | 1.0 (0.6) | 0.7 (0.6) | < 0.0001 | 0.83 |