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Table 3 Association of baseline variables with HAQ-DI and EQ-5D-3L index scores in biologic DMARD-experienced patients

From: Factors associated with disability in patients with rheumatoid arthritis with persistent moderate disease activity: a retrospective cohort study

Baseline variable 12-month HAQ-DI score 12-month change in HAQ-DI score 12-month EQ-5D-3L score 12-month change in EQ-5D-3L score
Univariate Multivariate Univariate Multivariate Univariate Multivariate Univariate Multivariate
β P β P β P β P β P β P β P β P
Age 0.01 0.003 0.00 0.554 0.00 0.698 0.00 0.510 0.00 0.510
Male sex −0.06 0.679 0.07 0.468 −0.30 0.119 0.01 0.886
White Ref Ref Ref Ref Ref Ref
Black −0.23 0.173 −0.08 0.527 0.12 0.574 0.03 0.620
Asian −0.39 0.218 −0.10 0.658 0.17 0.672 −0.08 0.542
Mixed −0.43 0.328 −0.07 0.813 0.66 0.341 0.05 0.815
Other −0.05 0.888 −0.26 0.291 0.51 0.255 0.23 0.106
Disease duration 0.00 0.667 0.00 0.845 0.01 0.395 0.00 0.862
RF positive −0.14 0.342 −0.12 0.249 0.12 0.535 0.02 0.730
Corticosteroids 0.31 0.026 0.09 0.369 0.00 0.968 −0.12 0.490 0.03 0.572
DAS28-ESR 0.00 0.986 −0.14 0.057 0.01 0.891 0.00 0.990 0.09 0.053 0.05 0.269
Swollen joint count −0.04 0.049 −0.01 0.391 0.00 0.991 0.04 0.138 0.01 0.510
Tender joint count −0.02 0.139 −0.02 0.001 −0.03 0.006 0.01 0.572 0.01 0.161
PtGA 0.01 0.014 0.00 0.401 0.00 0.060 0.00 0.421 −0.01 0.028 0.00 0.850 0.00 0.047 0.00 0.293
ESR 0.00 0.628 0.00 0.754 0.00 0.222 0.00 0.774
DMARD Ref Ref Ref Ref Ref Ref
Biologic 0.11 0.561 0.08 0.530 0.08 0.899 −0.04 0.604
DMARD biologic 0.02 0.902 −0.01 0.882 −0.02 0.899 −0.04 0.472
HAQ-DI 0.79 < 0.001 0.76 < 0.001 −0.21 < 0.001 −0.21 < 0.001 − 0.49 < 0.001 −0.29 0.004 0.03 0.283
EQ-5D-3L index −1.08 < 0.001 −0.02 0.949 0.28 0.053 −0.10 0.546 1.61 < 0.001 1.18 0.007 −0.50 < 0.001 −0.40 0.003
EQ-5D-3L pain 0.33 0.012 0.01 0.935 −0.11 0.211 −0.53 0.002 0.23 0.325 0.29 < 0.001 0.13 0.090
EQ-5D-3L anxiety/depression 0.23 0.019 0.05 0.544 −0.01 0.875 −0.54 < 0.001 −0.25 0.058 0.09 0.026 −0.02 0.674
  1. β- and P-values are from linear regression models that included endpoint HAQ-DI score, endpoint EQ-5D-3L index score (rank-transformed), 12-month change in HAQ-DI score or 12-month change in EQ-5D-3L index score as the response variable and each baseline variable as the explanatory variable (univariate model) or all baseline variables with P-values < 0.1 from univariate analysis (multivariate model); P-values shown in bold are significant (< 0.05)
  2. Abbreviations: DAS28-ESR Disease Activity Score for 28-joint count based on erythrocyte sedimentation rate, DMARD disease-modifying anti-rheumatic drug, EQ-5D-3L 3-level EuroQol 5-Dimensions questionnaire, ESR erythrocyte sedimentation rate, HAQ-DI Health Assessment Questionnaire-Disability Index, PtGA Patient Global Assessment of Disease Activity on a 10 cm visual analogue scale, Ref reference group, RF Rheumatoid factor