Fig. 1

Pain intensity and temporal aspect of pain. a Pain intensity including current, average and maximum pain levels of either total AID patients or NLRP3, MEFV and TNFRSF1A low penetrance variants alone are plotted on a numeric ranging scale (0 = no pain, 10 = maximum conceivable pain). Error bars indicate standard error of the mean. White columns: all patients; light grey columns: NLRP3; grey columns: MEFV, and dark grey columns: TNFRSF1A low penetrance variants. b Pain episodes of all patients (white columns), NLRP3 (light grey columns), MEFV (grey columns) and TNFRSF1A (dark grey columns) low penetrance variants alone are categorized as follows: persistent pain, recurrent attacks with asymptomatic intervals or attacks with persistent pain in between. Data are shown as relative numbers in percent (%)