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Table 1 Patient demographics, clinical characteristics and disease activity scores at baseline

From: Outcomes in rheumatoid arthritis patients treated with abatacept: a UK multi-centre observational study

Variable

All patients (n = 213)

By ACPA/RF status

ACPA+/RF+ (n = 76)

ACPA+ /RF- (n = 7)

ACPA- /RF+ (n = 10)

ACPA−/RF- (n = 22)

ACPA and/or RF status not recorded (n = 98)

Demographics (at index date unless specified)

 Age (years old)

  Mean (SD)

55.2 (13.1)

56.1 (12.9)

46.2 (6.6)

54.6 (13.3)

54.0 (15.2)

55.5 (13.1)

  Median (IQR)

55.4 (46.9–64.6)

56.2 (48.3–64.1)

47.8 (43.9–48.8)

51.4 (45.1–63.5)

57.5 (43.6–67.0)

55.1 (48.0–64.7)

 Sex

  Female, n (%)

152 (71.4%)

54 (71.1%)

a

10 (100.0%)

17 (77.3%)

66 (67.3%)

 Weight (kg)

  Mean (SD)

79.4 (17.8)

79.7 (18.7)

80.1 (12.6)

78.7 (16.0)

90.2 (23.0)

77.3 (16.1)

  Median (IQR)

77.2 (65.8–89.7)

76.2 (65.6–95.0)

79.4 (70.1–89.4)

71.9 (68.8–84.9)

86.2 (75.0–91.0)

76.8 (64.9–88.3)

 SBP (mmHg)

  Mean (SD)

134.8 (19.3)

131.5 (21.2)

129.7 (14.6)

145.3 (24.7)

143.8 (15.4)

135.0 (17.1)

  Median (IQR)

133.0 (120.0–146.5)

129.0 (114.5–142.5)

136.0 (124.5–138.0)

144.0 (124.8–163.5)

139.0 (134.0–158.5)

133.0 (120.0–147.5)

 DBP (mmHg)

  Mean (SD)

78.7 (10.9)

77.2 (11.0)

70.7 (7.4)

73.1 (11.8)

85.1 (12.1)

80.0 (10.0)

  Median (IQR)

78.0 (70.0–86.0)

75.0 (70.0–84.5)

68.0 (66.5–73.5)

71.0 (64.8–79.0)

83.5 (77.3–91.5)

79.5 (74.3–86.8)

 Smoking status

  Current smoker – n (%)

39 (18.3%)

14 (18.4%)

0 (0.0%)

a

a

21 (21.4%)

  Past smoker – n (%)

26 (12.2%)

15 (19.7%)

0 (0.0%)

a

a

7 (7.1%)

  Never smoked – n (%)

61 (28.6%)

20 (26.3%)

a

a

8 (36.4%)

25 (25.5%)

  Unknown – n (%)

87 (40.8%)

27 (35.5%)

a

a

7 (31.8%)

45 (45.9%)

 Year of RA diagnosis

  ≤2009– n (%)

39 (18.3%)

a

a

a

a

18 (18.4%)

  2010 – n (%)

45 (21.1%)

16 (21.1%)

a

a

a

22 (22.4%)

  2011 – n (%)

66 (31.0%)

17 (22.4%)

a

a

6 (27.3%)

39 (39.8%)

  2012 – n (%)

54 (25.4%)

26 (34.2%)

a

a

9 (40.9%)

a

  2013 – n (%)

9 (4.2%)

a

0 (0.0%)

a

0 (0.0%)

a

 RA duration at index date

  Mean (SD)

7.0 (7.9)

6.4 (8.1)

8.7 (8.1)

5.4 (6.5)

5.7 (5.4)

7.7 (8.2)

  Median (IQR)

3.9 (2.1–8.5)

3.3 (2.1–7.2)

4.6 (4.3–10.5)

2.2 (1.3–6.9)

3.8 (1.9–7.8)

5.1 (2.5–9.0)

 Patient history (5 years prior to index date), n (%)

  Myocardial infarction

8 (3.8%)

a

0 (0.0%)

0 (0.0%)

0 (0.0%)

a

  Other ischemic CV disease

11 (5.2%)

a

0 (0.0%)

0 (0.0%)

a

5 (5.1%)

  Stroke

5 (2.3%)

a

0 (0.0%)

0 (0.0%)

a

a

  Cancer

13 (6.1%)

6 (7.9%)

0 (0.0%)

a

a

a

  COPD

10 (4.7%)

a

0 (0.0%)

0 (0.0%)

a

6 (6.1%)

  Hypertension

44 (20.7%)

14 (18.4%)

a

a

5 (22.7%)

20 (20.4%)

  Asthma

30 (14.1%)

11 (14.5%)

a

a

5 (22.7%)

9 (9.2%)

  Interstitial lung disease

13 (6.1%)

7 (9.2%)

a

0 (0.0%)

a

a

  Diabetes

15 (7.0%)

8 (10.5%)

0 (0.0%)

0 (0.0%)

a

a

 ACPA titre (U/ml)

  n

119

76

a

10

22

a

  Median (IQR)

100.0 (8.2–600.0)

340.0 (100.0–600.0)

100.0 (100.0–300.5)

2.2 (0.3–5.3)

0.0 (0.0–1.0)

51.0 (30.9–123.0)

 RF titre (U/ml)

  n

180

76

7

10

22

65

  Median (IQR)

61.0 (16.9–100.0)

99.5 (52.3–100.0)

0.0 (0.0–11.6)

32.9 (21.8–90.8)

0.0 (0.0–6.8)

66.0 (27.0–100.0)

 DAS28-ESR score

  Mean (SD)

6.3 (1.0)

6.3 (0.9)

6.9 (0.9)

6.0 (0.9)

6.4 (0.8)

6.2 (1.2)

  Median (IQR)

6.3 (5.7–7.0)

6.4 (5.7–7.0)

6.7 (6.1–7.4)

5.4 (5.4–7.0)

6.3 (6.0–6.9)

6.2 (5.4–6.7)

  High – n (%)

89 (80.9%)

41 (80.4%)

7 (100.0%)

a

17 (94.4%)

22 (75.9%)

  Moderate – n (%)

20 (18.2%)

10 (19.6%)

0 (0.0%)

a

a

6 (20.7%)

  Low – n (%)

a

0 (0.0%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

a

  Remission – n (%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

 DAS28-CRP score

  Mean (SD)

5.5 (1.2)

5.8 (0.8)

6.4 (1.0)

5.3 (1.3)

6.0 (0.9)

5.2 (1.3)

  Median (IQR)

5.5 (4.8–6.3)

5.7 (5.2–6.3)

6.0 (5.8–6.6)

5.5 (4.5–6.1)

6.1 (5.5–6.7)

5.1 (4.3–6.3)

  High – n (%)

70 (51.9%)

27 (60.0%)

a

a

7 (70.0%)

29 (41.4%)

  Moderate – n (%)

60 (44.4%)

18 (40.0%)

0 (0.0%)

a

a

36 (51.4%)

  Low – n (%)

a

0 (0.0%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

a

  Remission – n (%)

a

0 (0.0%)

0 (0.0%)

0 (0.0%)

0 (0.0%)

a

  1. ACPA Anti-citrullinated protein antibodies, CV Cardiovascular, COPD Chronic obstructive pulmonary disease, CRP C-reactive protein, CV Cardiovascular, DAS28 Disease activity score, DBP Diastolic blood pressure, ESR Erythrocyte sedimentation rate, IQR Interquartile range, RF Rheumatoid factor, SBP Systolic blood pressure, SD Standard deviation
  2. aCells suppressed due to small numbers