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Table 1 Patient demographics, clinical characteristics and disease activity scores at baseline

From: Outcomes in rheumatoid arthritis patients treated with abatacept: a UK multi-centre observational study

Variable All patients (n = 213) By ACPA/RF status
ACPA+/RF+ (n = 76) ACPA+ /RF- (n = 7) ACPA- /RF+ (n = 10) ACPA−/RF- (n = 22) ACPA and/or RF status not recorded (n = 98)
Demographics (at index date unless specified)
Age (years old)
  Mean (SD) 55.2 (13.1) 56.1 (12.9) 46.2 (6.6) 54.6 (13.3) 54.0 (15.2) 55.5 (13.1)
  Median (IQR) 55.4 (46.9–64.6) 56.2 (48.3–64.1) 47.8 (43.9–48.8) 51.4 (45.1–63.5) 57.5 (43.6–67.0) 55.1 (48.0–64.7)
Sex
  Female, n (%) 152 (71.4%) 54 (71.1%) a 10 (100.0%) 17 (77.3%) 66 (67.3%)
Weight (kg)
  Mean (SD) 79.4 (17.8) 79.7 (18.7) 80.1 (12.6) 78.7 (16.0) 90.2 (23.0) 77.3 (16.1)
  Median (IQR) 77.2 (65.8–89.7) 76.2 (65.6–95.0) 79.4 (70.1–89.4) 71.9 (68.8–84.9) 86.2 (75.0–91.0) 76.8 (64.9–88.3)
SBP (mmHg)
  Mean (SD) 134.8 (19.3) 131.5 (21.2) 129.7 (14.6) 145.3 (24.7) 143.8 (15.4) 135.0 (17.1)
  Median (IQR) 133.0 (120.0–146.5) 129.0 (114.5–142.5) 136.0 (124.5–138.0) 144.0 (124.8–163.5) 139.0 (134.0–158.5) 133.0 (120.0–147.5)
DBP (mmHg)
  Mean (SD) 78.7 (10.9) 77.2 (11.0) 70.7 (7.4) 73.1 (11.8) 85.1 (12.1) 80.0 (10.0)
  Median (IQR) 78.0 (70.0–86.0) 75.0 (70.0–84.5) 68.0 (66.5–73.5) 71.0 (64.8–79.0) 83.5 (77.3–91.5) 79.5 (74.3–86.8)
Smoking status
  Current smoker – n (%) 39 (18.3%) 14 (18.4%) 0 (0.0%) a a 21 (21.4%)
  Past smoker – n (%) 26 (12.2%) 15 (19.7%) 0 (0.0%) a a 7 (7.1%)
  Never smoked – n (%) 61 (28.6%) 20 (26.3%) a a 8 (36.4%) 25 (25.5%)
  Unknown – n (%) 87 (40.8%) 27 (35.5%) a a 7 (31.8%) 45 (45.9%)
Year of RA diagnosis
  ≤2009– n (%) 39 (18.3%) a a a a 18 (18.4%)
  2010 – n (%) 45 (21.1%) 16 (21.1%) a a a 22 (22.4%)
  2011 – n (%) 66 (31.0%) 17 (22.4%) a a 6 (27.3%) 39 (39.8%)
  2012 – n (%) 54 (25.4%) 26 (34.2%) a a 9 (40.9%) a
  2013 – n (%) 9 (4.2%) a 0 (0.0%) a 0 (0.0%) a
RA duration at index date
  Mean (SD) 7.0 (7.9) 6.4 (8.1) 8.7 (8.1) 5.4 (6.5) 5.7 (5.4) 7.7 (8.2)
  Median (IQR) 3.9 (2.1–8.5) 3.3 (2.1–7.2) 4.6 (4.3–10.5) 2.2 (1.3–6.9) 3.8 (1.9–7.8) 5.1 (2.5–9.0)
Patient history (5 years prior to index date), n (%)
  Myocardial infarction 8 (3.8%) a 0 (0.0%) 0 (0.0%) 0 (0.0%) a
  Other ischemic CV disease 11 (5.2%) a 0 (0.0%) 0 (0.0%) a 5 (5.1%)
  Stroke 5 (2.3%) a 0 (0.0%) 0 (0.0%) a a
  Cancer 13 (6.1%) 6 (7.9%) 0 (0.0%) a a a
  COPD 10 (4.7%) a 0 (0.0%) 0 (0.0%) a 6 (6.1%)
  Hypertension 44 (20.7%) 14 (18.4%) a a 5 (22.7%) 20 (20.4%)
  Asthma 30 (14.1%) 11 (14.5%) a a 5 (22.7%) 9 (9.2%)
  Interstitial lung disease 13 (6.1%) 7 (9.2%) a 0 (0.0%) a a
  Diabetes 15 (7.0%) 8 (10.5%) 0 (0.0%) 0 (0.0%) a a
ACPA titre (U/ml)
  n 119 76 a 10 22 a
  Median (IQR) 100.0 (8.2–600.0) 340.0 (100.0–600.0) 100.0 (100.0–300.5) 2.2 (0.3–5.3) 0.0 (0.0–1.0) 51.0 (30.9–123.0)
RF titre (U/ml)
  n 180 76 7 10 22 65
  Median (IQR) 61.0 (16.9–100.0) 99.5 (52.3–100.0) 0.0 (0.0–11.6) 32.9 (21.8–90.8) 0.0 (0.0–6.8) 66.0 (27.0–100.0)
DAS28-ESR score
  Mean (SD) 6.3 (1.0) 6.3 (0.9) 6.9 (0.9) 6.0 (0.9) 6.4 (0.8) 6.2 (1.2)
  Median (IQR) 6.3 (5.7–7.0) 6.4 (5.7–7.0) 6.7 (6.1–7.4) 5.4 (5.4–7.0) 6.3 (6.0–6.9) 6.2 (5.4–6.7)
  High – n (%) 89 (80.9%) 41 (80.4%) 7 (100.0%) a 17 (94.4%) 22 (75.9%)
  Moderate – n (%) 20 (18.2%) 10 (19.6%) 0 (0.0%) a a 6 (20.7%)
  Low – n (%) a 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) a
  Remission – n (%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%)
DAS28-CRP score
  Mean (SD) 5.5 (1.2) 5.8 (0.8) 6.4 (1.0) 5.3 (1.3) 6.0 (0.9) 5.2 (1.3)
  Median (IQR) 5.5 (4.8–6.3) 5.7 (5.2–6.3) 6.0 (5.8–6.6) 5.5 (4.5–6.1) 6.1 (5.5–6.7) 5.1 (4.3–6.3)
  High – n (%) 70 (51.9%) 27 (60.0%) a a 7 (70.0%) 29 (41.4%)
  Moderate – n (%) 60 (44.4%) 18 (40.0%) 0 (0.0%) a a 36 (51.4%)
  Low – n (%) a 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) a
  Remission – n (%) a 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) a
  1. ACPA Anti-citrullinated protein antibodies, CV Cardiovascular, COPD Chronic obstructive pulmonary disease, CRP C-reactive protein, CV Cardiovascular, DAS28 Disease activity score, DBP Diastolic blood pressure, ESR Erythrocyte sedimentation rate, IQR Interquartile range, RF Rheumatoid factor, SBP Systolic blood pressure, SD Standard deviation
  2. aCells suppressed due to small numbers