Variable | All patients (n = 213) | By ACPA/RF status | ||||
---|---|---|---|---|---|---|
ACPA+/RF+ (n = 76) | ACPA+ /RF- (n = 7) | ACPA- /RF+ (n = 10) | ACPA−/RF- (n = 22) | ACPA and/or RF status not recorded (n = 98) | ||
Demographics (at index date unless specified) | ||||||
 Age (years old) | ||||||
  Mean (SD) | 55.2 (13.1) | 56.1 (12.9) | 46.2 (6.6) | 54.6 (13.3) | 54.0 (15.2) | 55.5 (13.1) |
  Median (IQR) | 55.4 (46.9–64.6) | 56.2 (48.3–64.1) | 47.8 (43.9–48.8) | 51.4 (45.1–63.5) | 57.5 (43.6–67.0) | 55.1 (48.0–64.7) |
 Sex | ||||||
  Female, n (%) | 152 (71.4%) | 54 (71.1%) | a | 10 (100.0%) | 17 (77.3%) | 66 (67.3%) |
 Weight (kg) | ||||||
  Mean (SD) | 79.4 (17.8) | 79.7 (18.7) | 80.1 (12.6) | 78.7 (16.0) | 90.2 (23.0) | 77.3 (16.1) |
  Median (IQR) | 77.2 (65.8–89.7) | 76.2 (65.6–95.0) | 79.4 (70.1–89.4) | 71.9 (68.8–84.9) | 86.2 (75.0–91.0) | 76.8 (64.9–88.3) |
 SBP (mmHg) | ||||||
  Mean (SD) | 134.8 (19.3) | 131.5 (21.2) | 129.7 (14.6) | 145.3 (24.7) | 143.8 (15.4) | 135.0 (17.1) |
  Median (IQR) | 133.0 (120.0–146.5) | 129.0 (114.5–142.5) | 136.0 (124.5–138.0) | 144.0 (124.8–163.5) | 139.0 (134.0–158.5) | 133.0 (120.0–147.5) |
 DBP (mmHg) | ||||||
  Mean (SD) | 78.7 (10.9) | 77.2 (11.0) | 70.7 (7.4) | 73.1 (11.8) | 85.1 (12.1) | 80.0 (10.0) |
  Median (IQR) | 78.0 (70.0–86.0) | 75.0 (70.0–84.5) | 68.0 (66.5–73.5) | 71.0 (64.8–79.0) | 83.5 (77.3–91.5) | 79.5 (74.3–86.8) |
 Smoking status | ||||||
  Current smoker – n (%) | 39 (18.3%) | 14 (18.4%) | 0 (0.0%) | a | a | 21 (21.4%) |
  Past smoker – n (%) | 26 (12.2%) | 15 (19.7%) | 0 (0.0%) | a | a | 7 (7.1%) |
  Never smoked – n (%) | 61 (28.6%) | 20 (26.3%) | a | a | 8 (36.4%) | 25 (25.5%) |
  Unknown – n (%) | 87 (40.8%) | 27 (35.5%) | a | a | 7 (31.8%) | 45 (45.9%) |
 Year of RA diagnosis | ||||||
  ≤2009– n (%) | 39 (18.3%) | a | a | a | a | 18 (18.4%) |
  2010 – n (%) | 45 (21.1%) | 16 (21.1%) | a | a | a | 22 (22.4%) |
  2011 – n (%) | 66 (31.0%) | 17 (22.4%) | a | a | 6 (27.3%) | 39 (39.8%) |
  2012 – n (%) | 54 (25.4%) | 26 (34.2%) | a | a | 9 (40.9%) | a |
  2013 – n (%) | 9 (4.2%) | a | 0 (0.0%) | a | 0 (0.0%) | a |
 RA duration at index date | ||||||
  Mean (SD) | 7.0 (7.9) | 6.4 (8.1) | 8.7 (8.1) | 5.4 (6.5) | 5.7 (5.4) | 7.7 (8.2) |
  Median (IQR) | 3.9 (2.1–8.5) | 3.3 (2.1–7.2) | 4.6 (4.3–10.5) | 2.2 (1.3–6.9) | 3.8 (1.9–7.8) | 5.1 (2.5–9.0) |
 Patient history (5 years prior to index date), n (%) | ||||||
  Myocardial infarction | 8 (3.8%) | a | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | a |
  Other ischemic CV disease | 11 (5.2%) | a | 0 (0.0%) | 0 (0.0%) | a | 5 (5.1%) |
  Stroke | 5 (2.3%) | a | 0 (0.0%) | 0 (0.0%) | a | a |
  Cancer | 13 (6.1%) | 6 (7.9%) | 0 (0.0%) | a | a | a |
  COPD | 10 (4.7%) | a | 0 (0.0%) | 0 (0.0%) | a | 6 (6.1%) |
  Hypertension | 44 (20.7%) | 14 (18.4%) | a | a | 5 (22.7%) | 20 (20.4%) |
  Asthma | 30 (14.1%) | 11 (14.5%) | a | a | 5 (22.7%) | 9 (9.2%) |
  Interstitial lung disease | 13 (6.1%) | 7 (9.2%) | a | 0 (0.0%) | a | a |
  Diabetes | 15 (7.0%) | 8 (10.5%) | 0 (0.0%) | 0 (0.0%) | a | a |
 ACPA titre (U/ml) | ||||||
  n | 119 | 76 | a | 10 | 22 | a |
  Median (IQR) | 100.0 (8.2–600.0) | 340.0 (100.0–600.0) | 100.0 (100.0–300.5) | 2.2 (0.3–5.3) | 0.0 (0.0–1.0) | 51.0 (30.9–123.0) |
 RF titre (U/ml) | ||||||
  n | 180 | 76 | 7 | 10 | 22 | 65 |
  Median (IQR) | 61.0 (16.9–100.0) | 99.5 (52.3–100.0) | 0.0 (0.0–11.6) | 32.9 (21.8–90.8) | 0.0 (0.0–6.8) | 66.0 (27.0–100.0) |
 DAS28-ESR score | ||||||
  Mean (SD) | 6.3 (1.0) | 6.3 (0.9) | 6.9 (0.9) | 6.0 (0.9) | 6.4 (0.8) | 6.2 (1.2) |
  Median (IQR) | 6.3 (5.7–7.0) | 6.4 (5.7–7.0) | 6.7 (6.1–7.4) | 5.4 (5.4–7.0) | 6.3 (6.0–6.9) | 6.2 (5.4–6.7) |
  High – n (%) | 89 (80.9%) | 41 (80.4%) | 7 (100.0%) | a | 17 (94.4%) | 22 (75.9%) |
  Moderate – n (%) | 20 (18.2%) | 10 (19.6%) | 0 (0.0%) | a | a | 6 (20.7%) |
  Low – n (%) | a | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | a |
  Remission – n (%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) |
 DAS28-CRP score | ||||||
  Mean (SD) | 5.5 (1.2) | 5.8 (0.8) | 6.4 (1.0) | 5.3 (1.3) | 6.0 (0.9) | 5.2 (1.3) |
  Median (IQR) | 5.5 (4.8–6.3) | 5.7 (5.2–6.3) | 6.0 (5.8–6.6) | 5.5 (4.5–6.1) | 6.1 (5.5–6.7) | 5.1 (4.3–6.3) |
  High – n (%) | 70 (51.9%) | 27 (60.0%) | a | a | 7 (70.0%) | 29 (41.4%) |
  Moderate – n (%) | 60 (44.4%) | 18 (40.0%) | 0 (0.0%) | a | a | 36 (51.4%) |
  Low – n (%) | a | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | a |
  Remission – n (%) | a | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | a |