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Table 1 Baseline and trend of the patient’s laboratory work-up

From: Potential contributors to low dose methotrexate toxicity in a patient with rheumatoid arthritis and pernicious anemia: case report

 

Baseline

Day 1

Day 4

Day 7

Day 13

2 months follow-up

8 months follow-up

Reference range and units

WBC

5140

1450

1920

2260

13,990

10,320

7650

3500–10,500 (cells/ul)

Absolute neutrophils

2990

420

840

990

6440

7970

5550

1700–7000 cells/ul

RBC count

2760

2700

2910

3090

2810

2980

3720

3900–5030 cells/ul

Hemoglobin

9.7

9.4

9.9

10.2

8.9

9.7

11.3

12–15.5 g/dl

MCV

105

104

104

102

110

109

105

82–98 fl

Platelets

161

82

49

311

688

150

156

150–450 units/ul

Creatinine

1.17

1.65

 

1.06

1.01

1.09

1.58

0.5–0.9 (mg/dl)

BUN

21

65

 

21

22

16

33

8–23 (mg/dl)

GFR

56

37

 

63

67

61

39

ml/min/1.73 m2

Reticulocyte count

 

0.36

 

2.41

4.44

  

0.6–1.8%

Serum folate

 

20

     

5–24 (ng/ml)

Vitamin B12

 

127

     

180–914 (pg/ml)

Vitamin D,25-OH

 

7

     

30–100 (ng/ml)

LDH

 

426

     

140–271 IU/l

  1. Methylentetrahydrofolate reductase genetic test: Negative for the variants C677T and A1298C