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Fig. 4 | BMC Rheumatology

Fig. 4

From: Characterization of the mechanism of action of lanraplenib, a novel spleen tyrosine kinase inhibitor, in models of lupus nephritis

Fig. 4

Serum proinflammatory cytokine concentrations are reduced in lanraplenib-treated NZB/W mice. a Geometric mean (± geo standard deviation) serum concentration of MCP-1 (left) and TNF-α (right) of individual mice. Each point represents an individual mouse. Limit of detection of assay is represented by a dashed line. Open circles indicate serum concentrations below the limit of detection. Statistics were calculated comparing the vehicle control group to each other group using Kruskal-Wallis tests. b Heat map summarizing the geometric mean fold-change comparing the vehicle control group to each indicated treatment group. *Indicates P < 0.05. **Indicates P < 0.005. ***Indicates P < 0.0005

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BMC Rheumatology

ISSN: 2520-1026

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