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Table 4 Researcher-informed recommendations for developing a core domain set for interventional studies targeting medication adherence in rheumatology

From: Researchers’ perspectives on methodological challenges and outcomes selection in interventional studies targeting medication adherence in rheumatic diseases: an OMERACT-adherence study

Recommendation CorrespondingTheme/Category
1. Specify benefits and consequences to support informed use of the core domain set byadherence researchers 3c
2. Involve patients, clinicians, decision makers, and other stakeholders in developing a coredomain set to represent and reflect respective priorities 3d
3. Consider the following aspects when establishing a core domain set  
-therapeutic area (e.g., clinical outcomes in rheumatology vary across conditions)
- culture of the target group (particularly when the experience with the intervention)
- research elements such as study objectives (pragmatic trials have different outcomes ofinterest than pilot studies) and study design (data source, data collection, analysis.
-logistical factors including feasibility and funding availability (whether researchers can affordto measure a certain outcome)
- the design of the intervention
4. Prioritize the following features of outcomes in a core domain set: 3b
-relevance (to the target patient population)
-feasibility (to implement, not cost-prohibitive)
-validity (have sound measurement properties)
5. Provide a complementary glossary for the core domain set to ensure consistent applicationand reporting 3d
6. Accompany the core domain set with guidelines to standardize measurement methods. 3d