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Table 1 timeline of events

From: Mechanic’s hand; is it a prodromic sign of disease relapse of anti-synthetase syndrome; a case report

Event Timeline
Development of proximal muscle weakness (1st episode) January 2017
Diagnosis and Immunosuppressive therapy with oral steroids and azathioprine February 2017
Clinical Remission March 2017 – September 2019
Development of Mechanic’s hands October 2019
Development of proximal muscle pain, weakness and elevation of CPK (2nd episode) December 2019
Escalation of immunosuppressive therapy with cyclophosphamide December 2019 – February 2020
Resolution of mechanic’s hands and normalization of CPK, pain and weakness January 2020