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Table 1 timeline of events

From: Mechanic’s hand; is it a prodromic sign of disease relapse of anti-synthetase syndrome; a case report

Event

Timeline

Development of proximal muscle weakness (1st episode)

January 2017

Diagnosis and Immunosuppressive therapy with oral steroids and azathioprine

February 2017

Clinical Remission

March 2017 – September 2019

Development of Mechanic’s hands

October 2019

Development of proximal muscle pain, weakness and elevation of CPK (2nd episode)

December 2019

Escalation of immunosuppressive therapy with cyclophosphamide

December 2019 – February 2020

Resolution of mechanic’s hands and normalization of CPK, pain and weakness

January 2020