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Table 3 Cox proportional hazards models for the entire group, males, and females (adjusted for the following covariates: age, ethnicity and original cohort, in addition to gender for the entire group analysis)

From: Longitudinal development of incident gout from low-normal baseline serum urate concentrations: individual participant data analysis

 

Adjusted models

Serum urate

Beta

SE

P

Hazard ratio

95% Lower CI

95% Upper CI

Referant < 4.0 mg/dL

All

4.0–4.49 mg/dL

0.671

0.343

0.050

1.96

1.00

3.83

4.5–4.99 mg/dL

0.357

0.347

0.304

1.43

0.72

2.82

5.0–5.49 mg/dL

0.502

0.335

0.134

1.65

0.86

3.19

5.5–5.99 mg/dL

0.957

0.317

0.003

2.60

1.40

4.85

6.0–6.49 mg/dL

1.308

0.308

0.000

3.70

2.02

6.77

6.5–6.99 mg/dL

1.657

0.305

0.000

5.24

2.88

9.53

≥7.00 mg/dL

2.924

0.279

0.000

18.62

10.78

32.15

Male

4.0–4.49 mg/dL

0.068

0.646

0.916

1.07

0.30

3.80

4.5–4.99 mg/dL

−0.381

0.627

0.543

0.68

0.20

2.33

5.0–5.49 mg/dL

−0.767

0.628

0.222

0.46

0.14

1.59

5.5–5.99 mg/dL

0.119

0.551

0.829

1.13

0.38

3.32

6.0–6.49 mg/dL

0.593

0.532

0.264

1.81

0.64

5.13

6.5–6.99 mg/dL

0.922

0.528

0.081

2.51

0.89

7.07

≥7.00 mg/dL

2.105

0.508

0.000

8.21

3.04

22.20

Female

4.0–4.49 mg/dL

0.649

0.406

0.110

1.91

0.86

4.25

4.5–4.99 mg/dL

0.369

0.422

0.381

1.45

0.63

3.31

5.0–5.49 mg/dL

0.819

0.399

0.040

2.27

1.04

4.95

5.5–5.99 mg/dL

0.981

0.412

0.017

2.67

1.19

5.98

6.0–6.49 mg/dL

1.052

0.438

0.016

2.86

1.21

6.76

6.5–6.99 mg/dL

1.422

0.439

0.001

4.14

1.75

9.80

≥7.00 mg/dL

2.958

0.345

0.000

19.27

9.80

37.87

  1. Abbreviations: SE Standard error, CI Confidence Interval