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Fig. 2 | BMC Rheumatology

Fig. 2

From: Ixekizumab improves sleep and work productivity in patients with non-radiographic axial spondyloarthritis: results from the COAST-X trial at 52 weeks

Fig. 2

Changes from baseline in Work Productivity and Activity Index Spondyloarthritis A) Absenteeism, B) Presenteeism, C) Overall Work Impairment, and D) Activity Impairment at Weeks 16 and 52 Values are LSM (SE) from mBOCF ANCOVA. Absenteeism, presenteeism, and overall work impairment were measured in patients reporting part- or full-time work. Absenteeism at Week 16: PBO, Nx = 50; IXE Q4W, Nx = 50; IXE Q2W, Nx = 53. Absenteeism at Week 52: PBO, Nx = 52; IXE Q4W, Nx = 50; IXE Q2W, Nx = 55. Presenteeism and Overall Work Impairment at Week 16: PBO, Nx = 47; IXE Q4W, Nx = 46; IXE Q2W = 50. Presenteeism and Overall Work Impairment at Week 52: PBO, Nx = 49; IXE Q4W, Nx = 46; IXE Q2W, Nx = 52. Activity Impairment at Weeks 16 and 52: PBO, Nx = 101; IXE Q4W, Nx = 96; IXE Q2W, Nx = 101. P values were from ANCOVA (treatment vs. placebo). * = p < 0.05, ‡ = p < 0.01, † = p < 0.001. ANCOVA = analysis of covariance; IXE Q2W = 80-mg ixekizumab every 2 weeks; IXE Q4W = 80-mg ixekizumab every 4 weeks; IXE Q4W = 80-mg ixekizumab every 2 weeks; LSM = least squares mean; mBOCF = modified baseline observation carried forward; N = number of patients in the treatment group; Nx = number of patients with non-missing values; PBO = placebo

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