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Table 3 Comparison of our patient and HLH-2004 criteria

From: Macrophage activation syndrome in MDA5 antibody-positive dermatomyositis and COVID-19 infection

HLH-2004 criteria

Our patient

Fever ≥  38.5 °C

Fever with temperature at 40 °C

Peripheral blood cytopenia, with at least two of the following: hemoglobin < 9 g/dL (for infants < 4 weeks, hemoglobin < 10 g/dL); platelets < 100,000/microL; absolute neutrophil count < 1000/microL

Hemoglobin 7.8 gm/dl and platelet count 83 k/µL

Hypertriglyceridemia (fasting triglycerides > 265 mg/dL) and hypofibrinogenemia (fibrinogen < 150 mg/dL)

Triglyceride level 1100 mg/dl

Ferritin > 500 ng/mL

Ferritin > 16,500 ng/mL