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Table 2 The distribution of HLA-DRB1 allele frequencies in RA patients and controls

From: Association of rheumatoid arthritis and its severity with human leukocytic antigen-DRB1 alleles in Kurdish region in North of Iraq

Genotype_HLA_DRB1

RA (n = 65)

Control (n = 100)

OR (95%)

P value

No

AF (%)

No

AF (%)

DRB1*0401

5

7.89

6

6

1.306 (0.38–4.46)

0.670

DRB1*0403

8

12.3

21

21

0.52 (0.21–1.276)

0.151

DRB1*0404

28

43.07

7

7

10.05 (4.04–25.02)

< 0.001

DRB1*0405

25

38.46

11

11

5.05 (2.26–11.27)

< 0.001

DRB1*0407

6

9.2

20

20

0.40 (0.15–1.07)

0.063

DRB1*0408

3

4.61

6

6

0.75 (0.18–3.14)

0.702

DRB1*0409

1

1.65

3

3

0.50 (0.051–4.9)

0.969

DRB1*0410

8

12.3

10

10

1.26 (0.47–3.38)

0.642

DRB1*0411

13

20

61

61

0.15 (0.07–0.33)

< 0.001

DRB1*0412

0

0

5

5

0.0 (0.0–?)

0.157

DRB1*0413

5

7.69

38

38

0.13 (0.050–0.36)

< 0.001

DRB1*0414

9

13.84

12

12

1.17 (0.46–2.97)

0.728

DRB1*0415

8

12.3

19

19

0.59 (0.24–1.46)

0.257

SE positive

48

73.84

46

46

3.31 (1.68–6.53)

< 0.001

  1. Shared epitope*0401, *0404, *0407, *0409 and*0410
  2. Values are number (%) unless otherwise indicated
  3. AF allele frequency, SE positive: the sum of DRB1*0401, *0404, *0407, *0409 and *0410, alleles; OR odds ratio; 95% Cl confidence interval at 95%. HLA frequencies observed in patients and controls were compared using the chi-square test. Differences were considered significant at P < 0.05