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Table 2 The distribution of HLA-DRB1 allele frequencies in RA patients and controls

From: Association of rheumatoid arthritis and its severity with human leukocytic antigen-DRB1 alleles in Kurdish region in North of Iraq

Genotype_HLA_DRB1 RA (n = 65) Control (n = 100) OR (95%) P value
No AF (%) No AF (%)
DRB1*0401 5 7.89 6 6 1.306 (0.38–4.46) 0.670
DRB1*0403 8 12.3 21 21 0.52 (0.21–1.276) 0.151
DRB1*0404 28 43.07 7 7 10.05 (4.04–25.02) < 0.001
DRB1*0405 25 38.46 11 11 5.05 (2.26–11.27) < 0.001
DRB1*0407 6 9.2 20 20 0.40 (0.15–1.07) 0.063
DRB1*0408 3 4.61 6 6 0.75 (0.18–3.14) 0.702
DRB1*0409 1 1.65 3 3 0.50 (0.051–4.9) 0.969
DRB1*0410 8 12.3 10 10 1.26 (0.47–3.38) 0.642
DRB1*0411 13 20 61 61 0.15 (0.07–0.33) < 0.001
DRB1*0412 0 0 5 5 0.0 (0.0–?) 0.157
DRB1*0413 5 7.69 38 38 0.13 (0.050–0.36) < 0.001
DRB1*0414 9 13.84 12 12 1.17 (0.46–2.97) 0.728
DRB1*0415 8 12.3 19 19 0.59 (0.24–1.46) 0.257
SE positive 48 73.84 46 46 3.31 (1.68–6.53) < 0.001
  1. Shared epitope*0401, *0404, *0407, *0409 and*0410
  2. Values are number (%) unless otherwise indicated
  3. AF allele frequency, SE positive: the sum of DRB1*0401, *0404, *0407, *0409 and *0410, alleles; OR odds ratio; 95% Cl confidence interval at 95%. HLA frequencies observed in patients and controls were compared using the chi-square test. Differences were considered significant at P < 0.05