|
Genotype_HLA_DRB1
|
RA (n = 65)
|
Control (n = 100)
|
OR (95%)
|
P value
|
|---|
|
No
|
AF (%)
|
No
|
AF (%)
|
|---|
|
DRB1*0401
|
5
|
7.89
|
6
|
6
|
1.306 (0.38–4.46)
|
0.670
|
|
DRB1*0403
|
8
|
12.3
|
21
|
21
|
0.52 (0.21–1.276)
|
0.151
|
|
DRB1*0404
|
28
|
43.07
|
7
|
7
|
10.05 (4.04–25.02)
|
< 0.001
|
|
DRB1*0405
|
25
|
38.46
|
11
|
11
|
5.05 (2.26–11.27)
|
< 0.001
|
|
DRB1*0407
|
6
|
9.2
|
20
|
20
|
0.40 (0.15–1.07)
|
0.063
|
|
DRB1*0408
|
3
|
4.61
|
6
|
6
|
0.75 (0.18–3.14)
|
0.702
|
|
DRB1*0409
|
1
|
1.65
|
3
|
3
|
0.50 (0.051–4.9)
|
0.969
|
|
DRB1*0410
|
8
|
12.3
|
10
|
10
|
1.26 (0.47–3.38)
|
0.642
|
|
DRB1*0411
|
13
|
20
|
61
|
61
|
0.15 (0.07–0.33)
|
< 0.001
|
|
DRB1*0412
|
0
|
0
|
5
|
5
|
0.0 (0.0–?)
|
0.157
|
|
DRB1*0413
|
5
|
7.69
|
38
|
38
|
0.13 (0.050–0.36)
|
< 0.001
|
|
DRB1*0414
|
9
|
13.84
|
12
|
12
|
1.17 (0.46–2.97)
|
0.728
|
|
DRB1*0415
|
8
|
12.3
|
19
|
19
|
0.59 (0.24–1.46)
|
0.257
|
|
SE positive
|
48
|
73.84
|
46
|
46
|
3.31 (1.68–6.53)
|
< 0.001
|
- Shared epitope*0401, *0404, *0407, *0409 and*0410
- Values are number (%) unless otherwise indicated
- AF allele frequency, SE positive: the sum of DRB1*0401, *0404, *0407, *0409 and *0410, alleles; OR odds ratio; 95% Cl confidence interval at 95%. HLA frequencies observed in patients and controls were compared using the chi-square test. Differences were considered significant at P < 0.05
