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Table 3 Uric acid risk allele frequencies comparisons Asian and Native Hawaiian and Pacific Islanders Subgroups

From: Genetic assessment of hyperuricemia and gout in Asian, Native Hawaiian, and Pacific Islander subgroups of pregnant women: biospecimens repository cross-sectional study

Gene (SNP)

Variant Type

Allele

EUR† % (n)

Filipino % (n)

Korean % (n)

Japanese % (n)

Native Hawaiian % (n)

Marshallese % (n)

Samoan % (n)

Gout/ Urate Effect (↑↓)

ABCG2

(rs2231142 G > T)

Missense

G

T

90.6 (911)

9.4 (95)

54.2 (194)*

45.8 (164)

72.2 (133)*

27.8 (51)

74.4 (278) *

25.6 (96)

87.3 (253)

12.7(37)

82.4 (201)*

17.6 (43)

68.9 (251)*

31.1 (113)

↑

SLC2A9

(rs734553 G > T)

Intronic

G

T

24.5 (246)

75.5 (760)

1.2 (4)*

98.8 (348)

1.7 (3)*

98.3 (183)

0.5 (2)*

99.5 (368)

9.1 (26)*

90.9 (260)

0.0 (0)*

100.0 (242)

1.7 (6)*

98.3 (358)

↑

SLC17A1

(rs1183201T > A)

Intronic

A

T

46.1 (464)

53.9 (542)

20.9 (73) *

79.1 (277)

14.6 (26)*

85.4 (152)

17.1 (63)*

82.9 (305)

34.0 (98)*

66.0 (190)

57.2 (135)*

42.8 (101)

28.4(103)*

71.6 (259)

↓

SLC16A9

(s2242206 G > T)

Missense

G

T

73.4 (738)

26.6 (268)

55.0 (197)*

45.0 (161)

40.8 (75) *

59.2 (109)

44.5 (163)*

55.5 (203)

54.9(158)*

45.1 (130)

55.5 (132)*

44.5 (238)

60.7(221)*

39.3 (143)

↓

GCKR

(rs780094 C > T)

Intronic

C

T

58.9 (593)

41.1 (413)

55.1 (197)

44.9 (161)

58.2 (107)

41.8 (77)

42.0 (156) *

58.0 (216)

65.9 (190)

34.1 (98)

64.5 (156)

35.5 (86)

69.4(254)*

30.6 (112)

↑

SLC22A11  (rs17300741G > A)

Intronic

A

G

46.2 (465)

53.8 (541)

85.3 (297)* 14.7 (51)

89.6 (163)*

10.4 (19)

84.7(305) *

15.3 (55)

72.3 (201) *

27.7 (77)

70.0 (167) *

30.0 (73)

78.5 (281)*

21.5 (77)

↑

SLC22A12

(rs505802 C > T)

Intergenic

T

C

70.7 (711)

29.3 (295)

21.6 (79)*

78.4 (287)

20.4 (38)*

79.6 (148)

18.3 (68)*

81.7 (304)

37.6 (109)*

62.4 (181)

5.0 (12) *

95.0 (230)

31.5(116)*

68.5 (252)

↓

LRRC16A (rs742132 G > A)

Intronic

A

G

69.0 (694)

31.0 (312)

69.7 (251)

30.3 (109)

78.0 (142)

22.0 (40)

78.2 (291)*

21.8 (81)

58.6 (171)*

41.4 (121)

70.0 (168)

30.0 (72)

51.7 (188)*

48.3 (176)

↑

PDZK1**

(rs12129861 C > T)

Intergenic

C

T

54.1 (544)

45.9 (462)

44.7 (151)*

55.3 (187)

56.8 (92)

43.2 (70)

48.9 (178)

51.1 (186)

39.3 (106)*

60.7 (164)

39.5 (90)*

60.5 (138)

46.5 (159)*

53.5 (183)

↓

  1. The bolded letter refers to the risk allele linked to hyperuricemia or gout
  2. *Indicates statistical significance p < 0.006 between the subgroups and the comparator group (EUR)
  3. †Data from the 1000 Genomes Project Phase III
  4. **Allele deviated from HWE in all study subgroups