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Table 3 Uric acid risk allele frequencies comparisons Asian and Native Hawaiian and Pacific Islanders Subgroups

From: Genetic assessment of hyperuricemia and gout in Asian, Native Hawaiian, and Pacific Islander subgroups of pregnant women: biospecimens repository cross-sectional study

Gene (SNP) Variant Type Allele EUR† % (n) Filipino % (n) Korean % (n) Japanese % (n) Native Hawaiian % (n) Marshallese % (n) Samoan % (n) Gout/ Urate Effect (↑↓)
ABCG2
(rs2231142 G > T)
Missense G
T
90.6 (911)
9.4 (95)
54.2 (194)*
45.8 (164)
72.2 (133)*
27.8 (51)
74.4 (278) *
25.6 (96)
87.3 (253)
12.7(37)
82.4 (201)*
17.6 (43)
68.9 (251)*
31.1 (113)
SLC2A9
(rs734553 G > T)
Intronic G
T
24.5 (246)
75.5 (760)
1.2 (4)*
98.8 (348)
1.7 (3)*
98.3 (183)
0.5 (2)*
99.5 (368)
9.1 (26)*
90.9 (260)
0.0 (0)*
100.0 (242)
1.7 (6)*
98.3 (358)
SLC17A1
(rs1183201T > A)
Intronic A
T
46.1 (464)
53.9 (542)
20.9 (73) *
79.1 (277)
14.6 (26)*
85.4 (152)
17.1 (63)*
82.9 (305)
34.0 (98)*
66.0 (190)
57.2 (135)*
42.8 (101)
28.4(103)*
71.6 (259)
SLC16A9
(s2242206 G > T)
Missense G
T
73.4 (738)
26.6 (268)
55.0 (197)*
45.0 (161)
40.8 (75) *
59.2 (109)
44.5 (163)*
55.5 (203)
54.9(158)*
45.1 (130)
55.5 (132)*
44.5 (238)
60.7(221)*
39.3 (143)
GCKR
(rs780094 C > T)
Intronic C
T
58.9 (593)
41.1 (413)
55.1 (197)
44.9 (161)
58.2 (107)
41.8 (77)
42.0 (156) *
58.0 (216)
65.9 (190)
34.1 (98)
64.5 (156)
35.5 (86)
69.4(254)*
30.6 (112)
SLC22A11  (rs17300741G > A) Intronic A
G
46.2 (465)
53.8 (541)
85.3 (297)* 14.7 (51) 89.6 (163)*
10.4 (19)
84.7(305) *
15.3 (55)
72.3 (201) *
27.7 (77)
70.0 (167) *
30.0 (73)
78.5 (281)*
21.5 (77)
SLC22A12
(rs505802 C > T)
Intergenic T
C
70.7 (711)
29.3 (295)
21.6 (79)*
78.4 (287)
20.4 (38)*
79.6 (148)
18.3 (68)*
81.7 (304)
37.6 (109)*
62.4 (181)
5.0 (12) *
95.0 (230)
31.5(116)*
68.5 (252)
LRRC16A (rs742132 G > A) Intronic A
G
69.0 (694)
31.0 (312)
69.7 (251)
30.3 (109)
78.0 (142)
22.0 (40)
78.2 (291)*
21.8 (81)
58.6 (171)*
41.4 (121)
70.0 (168)
30.0 (72)
51.7 (188)*
48.3 (176)
PDZK1**
(rs12129861 C > T)
Intergenic C
T
54.1 (544)
45.9 (462)
44.7 (151)*
55.3 (187)
56.8 (92)
43.2 (70)
48.9 (178)
51.1 (186)
39.3 (106)*
60.7 (164)
39.5 (90)*
60.5 (138)
46.5 (159)*
53.5 (183)
  1. The bolded letter refers to the risk allele linked to hyperuricemia or gout
  2. *Indicates statistical significance p < 0.006 between the subgroups and the comparator group (EUR)
  3. Data from the 1000 Genomes Project Phase III
  4. **Allele deviated from HWE in all study subgroups