Fig. 3

Cumulative incidence of fragility fractures in different subgroups. a History of prior vertebral fracture. b Dose of methotrexate. c Number of risk factors. Figure 3 showed the cumulative incidence of fragility fractures with or without predictors. The endpoint was defined as the development of any fragility fractures. Subgroups were divided according to the following definitions; a presence or absence of a history of fractures, b > 4 or ≤ 4 mg/week of dose of methotrexate, and c number of risk factors (0–2). Risk factors included a history of prior vertebral fracture and ≤ 4 mg/week dose of methotrexate