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Table 3 S100A8/A9 concentrations and clinical characteristics in NPSLE and non-NPSLE patients applying three NPSLE attribution models

From: Serum S100A8/A9 concentrations are associated with neuropsychiatric involvement in systemic lupus erythematosus: a cross-sectional study

 

SLICC A model

SLICC B model

ACR model

NPSLE

Non-NPSLE

p value

NPSLE

Non-NPSLE

p value

NPSLE

Non-NPSLE

p value

Serum S100A8/A9, ng/ml, median (range)

1560 (280–3520)

1090 (50–3540)

0.050

1460 (260–3520)

1090 (50–3540)

0.084

1400 (140–3540)

920 (50–3500)

0.011

CSF S100A8/A9, pg/ml, median (range)

316 (< 35–854)

351 (< 35–2045)

0.83

316 (< 35–1703)

351 (< 35–2045)

1.0

319 (< 35–1703)

416 (< 35–2045)

0.43

Age at study, median (range), years

41 (24–48)

36 (18–52)

0.23

39 (23–48)

37 (18–52)

0.90

40 (18–50)

35 (19–52)

0.28

Disease duration, median (range), years

10.5 (1–24)

9.5 (0–32)

0.18

10 (1–29)

10 (0–32)

0.90

10 (0–32)

10 (0–25)

0.43

SLICC/ACR-DI, median (range)

1 (0–5)

0 (0–4)

0.008

1 (0–5)

0 (0–4)

0.003

0 (0–5)

0 (0–3)

0.18

SLEDAI-2 K, median (range)

2 (0–12)

2 (0–18)

0.63

2 (0–12)

2 (0–18)

0.70

2 (0–18)

2 (0–12)

0.65

  1. SLICC: Systemic Lupus Erythematosus International Collaborating Clinics. ACR: American College of Rheumatology. CSF: cerebrospinal fluid. DI: Damage Index. SLEDAI-2 K: SLE Disease Activity Index 2000