(Dis)agreement of polymyalgia rheumatica relapse criteria, and prediction of relapse in a retrospective cohort

BMC Rheumatology

Table 2 Univariable associations between predictors and different outcomes of relapse

Predictors	Relapse within year 0–1				Relapse within year 0–2				Relapses per patient per year
Predictors	OR	95% CI		p	OR	95% CI		p	IRR	95% CI		p
Age (years)	1.00	0.98	0.92	0.92	1.00	0.76	1.02	0.76	1.00	0.99	1.01	0.87
Sex (reference category: male)	1.42	0.930	0.11	0.11	1.36	0.12	2.01	0.12	1.00	0.78	1.26	0.96
Positive medical history (reference category: no)
Inflammatory disease	1.20	0.76	0.43	0.43	1.01	0.96	1.55	0.96	1.21	0.94	1.58	0.14
Malignancy	0.62	0.32	0.17	0.17	0.96	0.68	1.60	0.68	0.91	0.62	1.34	0.63
Cardiovascular disease	1.70	0.97	0.06	0.06	1.76	0.05	3.07	0.05	1.20	0.89	1.64	0.24
Smoking (reference category: no)¹
Stopped	0.87	0.50	0.61	0.61	1.18	0.52	1.96	0.52	1.29	0.96	1.74	0.09
Yes	0.82	0.42	0.57	0.57	1.00	0.99	1.86	0.99	0.97	0.67	1.40	0.86
Symptom duration before baseline in months¹	*0.92*	*0.85*	*0.03*	*0.03*	*0.92*	*0.02*	*0.99*	*0.02*	0.96	0.92	1.00	0.09
Clinical disease severity (score 0–8)	0.93	0.81	0.29	0.29	0.92	0.20	1.05	0.20	0.94	0.86	1.01	0.10
(Suspected) presence of peripheral arthritis (reference category: no)	0.74	0.41	0.32	0.32	0.68	0.17	1.18	0.17	0.79	0.54	1.15	0.22
Presence of systemic symptoms (reference category: no)	0.80	0.52	0.29	0.29	0.86	0.44	1.27	0.44	1.00	0.79	1.27	0.98
CRP per 10 mg/L²	*1.08*	*1.01*	*0.02*	*0.02*	*1.09*	*0.01*	*1.16*	*0.01*	*1.04*	*1.01*	*1.08*	*0.03*
ESR per 10 mm/h³	*1.20*	*1.08*	*0.00*	*0.00*	*1.22*	*0.00*	*1.35*	*0.00*	*1.09*	*1.03*	*1.15*	*0.00*
Hb per mmol/L⁴	1.03	0.75	0.88	0.88	0.99	0.94	1.32	0.94	1.03	0.86	1.25	0.73

n, number; CRP, C-Reactive Protein; ESR, erythrocyte sedimentation rate; Hb, hemoglobin; APR, acute phase reactants; OR, odds ratio; CI, confidence interval; IRR, incidence rate ratio
Bold, italic results show significance at a p value < 0.05. ¹n = 411, ²n = 364, ³n = 396, ⁴n = 317

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