Table 3 Univariable and multivariable logistic regression analyses with backward elimination process to find the predictors of severe lupus flare-up
From: Predictors of severe lupus flare: a prospective follow-up study
Independent variables | OR | 95% confidence interval (CI) | P | OR | 95% confidence interval (CI) | P | ||
|---|---|---|---|---|---|---|---|---|
Lower | Upper | Lower | Upper | |||||
Age | 0.903 | 0.857 | 0.952 | 0.0001 | 0.869 | 0.804 | 0.939 | 0.0001 |
History of nephritis | 4.193 | 1.85 | 9.505 | 0.001 | 4.66 | 1.551 | 14.002 | 0.006 |
SLEDAI at the first visit | 1.288 | 1.144 | 1.449 | 0.0001 | 1.191 | 1.026 | 1.382 | 0.02 |
Sex | 3.018 | 1.016 | 8.966 | 0.047 | Removed by backward elimination process | |||
Disease duration | 0.958 | 0.909 | 1.011 | 0.10 | ||||
History of cardiovascular diseases | 1 | 1 | 1 | 0.99 | ||||
History of diabetes | 1 | 1 | 1 | 0.99 | ||||
History of hypertension | 0.724 | 0.294 | 1.781 | 0.50 | ||||
Anticardiolipin antibody (IgG) | 0.801 | 0.328 | 1.953 | 0.65 | ||||
Anticardiolipin antibody (IgM) | 0.858 | 0.324 | 2.274 | 0.75 | ||||
Anti-beta 2 glycoprotein I antibody (IgM) | 1 | 1 | 1 | 0.99 | ||||
Anti-beta 2 glycoprotein I antibody (IgG) | 0.968 | 0.257 | 3.642 | 0.95 | ||||
Antiphospholipid syndrome | 0.621 | 0.2 | 1.924 | 0.40 | ||||
Anti-ds-DNA at the first visit | 2.543 | 1.142 | 5.664 | 0.02 | ||||
Low C3 at the first visit | 1.649 | 0.776 | 3.506 | 0.20 | ||||
Low C4 at the first visit | 1.296 | 0.57 | 2.946 | 0.50 | ||||
Creatinine at the first visit | 1.502 | 0.345 | 6.528 | 0.60 | ||||
24-hour proteinuria at the first visit | 1.006 | 0.989 | 1.023 | 0.50 | ||||
BUN at the first visit | 1.014 | 0.97 | 1.059 | 0.55 | ||||
GFR at the first visit | 1.007 | 0.99 | 1.024 | 0.40 | ||||
ESR at the first visit | 0.999 | 0.975 | 1.024 | 0.95 | ||||
CRP at the first visit | 1.403 | 0.529 | 3.717 | 0.50 | ||||
WBC at the first visit | 1 | 1 | 1 | 0.20 | ||||
Platelet at the first visit | 1 | 1 | 1 | 0.20 | ||||
Hemoglobin at the first visit | 1.127 | 0.916 | 1.386 | 0.25 | ||||
Dose of prednisolone at the first visit | 1.022 | 0.97 | 1.077 | 0.40 | ||||
Cumulative dose of prednisolone | 1.000 | 1.000 | 1.001 | 0.001 | ||||
Use of hydroxychloroquine at the first visit | 1.969 | 0.789 | 4.911 | 0.15 | ||||
Use of azathioprine at the first visit | 2.173 | 0.823 | 5.737 | 0.10 | ||||
Use of cyclophosphamide at the first visit | 1.591 | 0.307 | 8.235 | 0.60 | ||||
Use of mycophenolate mofetil at the first visit | 1.432 | 0.636 | 3.226 | 0.40 | ||||
Use of methotrexate at the first visit | 1 | 1 | 1 | 0.99 | ||||
Use of tacrolimus at the first visit | 1.244 | 0.43 | 3.606 | 0.70 | ||||