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Clinical rheumatology

Section edited by Susan Goodman (New York, US)

This section is concerns all aspects of clinical rheumatology

Page 1 of 2

  1. Long-term clinical registries are essential tools to evaluate new therapies in a patient population that differs from those in randomized clinical trials. The objectives are to describe the profile of rheumato...

    Authors: Proton Rahman, Philip Baer, Ed Keystone, Denis Choquette, Carter Thorne, Boulos Haraoui, Andrew Chow, Rafat Faraawi, Wojciech Olszynski, John Kelsall, Emmanouil Rampakakis, Allen J. Lehman and Francois Nantel

    Citation: BMC Rheumatology 2020 4:46

    Content type: Research article

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  2. Cases of exacerbation of pre-existing neuromuscular diseases induced by immune checkpoint inhibitors (ICIs) have rarely been reported because patients with autoimmune diseases have generally been excluded from...

    Authors: Naohiro Uchio, Atsushi Unuma, Toshiyuki Kakumoto, Masao Osaki, Yoshitaka Zenke, Kenichi Sakuta, Akatsuki Kubota, Yoshikazu Uesaka, Tatsushi Toda and Jun Shimizu

    Citation: BMC Rheumatology 2020 4:48

    Content type: Case report

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  3. To determine whether initiation of a tumor necrosis factor inhibitor (TNFi) or methotrexate improves hemoglobin A1c in patients with psoriatic arthritis (PsA), rheumatoid arthritis (RA), or ankylosing spondyli...

    Authors: Santhi Mantravadi, Michael George, Colleen Brensinger, Min Du, Joshua F. Baker and Alexis Ogdie

    Citation: BMC Rheumatology 2020 4:39

    Content type: Research article

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  4. Proteasomes are found in both the cell nucleus and cytoplasm and play a major role in the ubiquitin-dependent and -independent non-lysosomal pathways of intracellular protein degradation. Proteasomes are also ...

    Authors: Hiroshi Maruyama, Kouichi Hirayama, Marina Yamashita, Kentaro Ohgi, Ryuji Tsujimoto, Mamiko Takayasu, Homare Shimohata and Masaki Kobayashi

    Citation: BMC Rheumatology 2020 4:36

    Content type: Research article

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  5. Giant cell arteritis (GCA) is a common large vessel vasculitis of the elderly, often associated with sight loss. Glucocorticoids (GC remain the mainstay of treatment, although biologic treatments have been app...

    Authors: Alwin Sebastian, Kornelis S. M. van der Geest, Fiona Coath, Prisca Gondo, Abdul Kayani, Craig Mackerness, Bernard Hadebe, Sue Innes, Jo Jackson and Bhaskar Dasgupta

    Citation: BMC Rheumatology 2020 4:35

    Content type: Study protocol

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  6. Retroperitoneal fibrosis (RPF) is characterized by the proliferation of fibrous tissue in the retroperitoneum. The majority of RPF cases are due to idiopathic or IgG4-related disease. Recent studies on IgG4-re...

    Authors: Veronika Boyeva, Hatim Alabsi, Michael A. Seidman, Ryan Paterson, Jason Kur, Luke Y. C. Chen, Silvia D. Chang and Mollie Carruthers

    Citation: BMC Rheumatology 2020 4:40

    Content type: Research article

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  7. Patients treated for cancer with immune checkpoint inhibitors (ICI) may develop autoimmune adverse events, including ICI-induced inflammatory arthritis (IA). ICI-induced IA treatment requires balancing immune ...

    Authors: Laura C. Cappelli, Suzanne M. Grieb, Ami A. Shah, Clifton O. Bingham III and Ana-Maria Orbai

    Citation: BMC Rheumatology 2020 4:32

    Content type: Research article

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  8. To gain insight in the use of current systemic sclerosis (SSc) care provided by health professionals from the patient perspective. We focused on referral reasons, treatment goals, the alignment with unmet care...

    Authors: Juliane K. Stöcker, Madelon C. Vonk, Frank H. J. van den Hoogen, Maria W. G. Nijhuis-van der Sanden, Julia Spierings, J. Bart Staal, Ton Satink and Cornelia H. M. van den Ende

    Citation: BMC Rheumatology 2020 4:43

    Content type: Research article

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  9. Dose loading of biological disease modifying anti-rheumatic drugs (bDMARDs) in auto-immune rheumatic diseases (AIRDs) is performed to achieve steady state drug concentrations earlier after treatment start comp...

    Authors: Gerlienke E. Geurts-Voerman, Lise M. Verhoef, Bart J. F. van den Bemt and Alfons A. den Broeder

    Citation: BMC Rheumatology 2020 4:37

    Content type: Research article

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  10. Previous studies have linked rheumatoid arthritis (RA) risk and disease activity with vitamin D-deficiency (low serum 25-hydroxyvitamin D (25OHD)), but a causal role for vitamin D in RA is still unclear, with ...

    Authors: Stephanie R. Harrison, Gurpreet Jutley, Danyang Li, Ilfita Sahbudin, Andrew Filer, Martin Hewison and Karim Raza

    Citation: BMC Rheumatology 2020 4:38

    Content type: Research article

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  11. Line blot immunoassays (LIA) for myositis-specific (MSA) and myositis-associated (MAA) autoantibodies have become commercially available. In the largest study of this kind, we evaluated the clinical performanc...

    Authors: Fergus To, Clara Ventín-Rodríguez, Shuayb Elkhalifa, James B. Lilleker and Hector Chinoy

    Citation: BMC Rheumatology 2020 4:28

    Content type: Research article

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  13. Inflammatory Arthritis is characterized by lifelong medical treatment and an unpredictable trajectory because of the fluctuating nature of the diseases. Proactive disease management is recommended, which inclu...

    Authors: Bianca Bech, Jens Jørgen Lykkegaard, Tine Lundbak, Heidi Morsø Schrøder, Line Mette Birkeland, Mette Lund Schlyter, Lotte Hanne Hansen, Lillian Dalsgaard and Bente Appel Esbensen

    Citation: BMC Rheumatology 2020 4:44

    Content type: Research article

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  14. Immune-mediated necrotising myopathy (IMNM) is characterised by severe muscle weakness and necrosis with a paucity of inflammation on muscle biopsy. Around 60% of cases are associated with antibodies to the si...

    Authors: Rhys Thomas, Su-Ann Yeoh, Rupert Berkeley, Andrew Woods, Mike Stevens, Silvia Marino and Aleksandar Radunovic

    Citation: BMC Rheumatology 2020 4:29

    Content type: Case report

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  15. It is plausible that optimal cardiovascular disease (CVD) risk management differs in patients with rheumatoid arthritis (RA) from low or middle income compared to high income populations. This study aimed at p...

    Authors: Ahmed Solomon, Anne E. Stanwix, Santos Castañeda, Javier Llorca, Carlos Gonzalez-Juanatey, Bridget Hodkinson, Benitha Romela, Mahmood M. T. M. Ally, Ajesh B. Maharaj, Elsa M. Van Duuren, Joyce J. Ziki, Mpoti Seboka, Makgotso Mohapi, Barend J. Jansen Van Rensburg, Gareth S. Tarr, Kavita Makan…

    Citation: BMC Rheumatology 2020 4:42

    Content type: Research article

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  16. Disease-modifying antirheumatic drugs (DMARDs) have transformed the treatment of numerous autoimmune and inflammatory diseases but their perceived risk of harm may be a barrier to use.

    Authors: Hiba EL Masri, Samantha A. Hollingworth, Mieke van Driel, Helen Benham and Treasure M. McGuire

    Citation: BMC Rheumatology 2020 4:27

    Content type: Research article

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  17. Our study aimed to compare efficacy and safety of Hetero’s adalimumab (Mabura®, Hetero Biopharma Limited) versus reference adalimumab (Humira®, Abbvie Inc.) in Indian patients with active rheumatoid arthritis ...

    Authors: Shubhadeep Sinha, Biswadip Ghosh, Syamasis Bandyopadhyay, Firdaus Fatima, Vamsi Krishna Bandi, Pankaj Thakur, Bala Reddy, Sreenivasa Chary, Leela Talluri, Ajay Gupta, Amit Ramchandra Kale, Anil Kumar Gupta, Ashok Kumar P, Diwakar Reddy, Younus Mohammed, Soma Shekar…

    Citation: BMC Rheumatology 2020 4:24

    Content type: Research article

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  18. In this commentary, we discuss the potential of advanced imaging, particularly Dynamic Contrast Enhanced (DCE) magnetic resonance imaging (MRI) for the objective assessment of the inflammatory process in rheum...

    Authors: Ali Mobasheri, Mark Hinton, Faiq Shaikh and Olga Kubassova

    Citation: BMC Rheumatology 2020 4:33

    Content type: Commentary

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  19. Severe spinal pain is an unusual presentation of gout. Due to its rarity and the difficulty of obtaining joint fluid or tissue for crystal analysis, dual energy computed tomography (DECT) may be a useful imagi...

    Authors: Jeremy X. Wang, Beverly Ng, Haesung Bak, David Spencer, Nicholas Manolios and Peter K. K. Wong

    Citation: BMC Rheumatology 2020 4:22

    Content type: Case report

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  20. Various inflammatory conditions may present with musculoskeletal symptoms similar to those of polymyalgia rheumatica (PMR). We investigated findings on 18F-fluorodexoxyglucose (FDG)-positron emission tomography/c...

    Authors: Hideyuki Horikoshi, Takashi Nakanishi, Katsumi Tamura, Fumihiko Kimura and Kenji Itoh

    Citation: BMC Rheumatology 2020 4:21

    Content type: Research article

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  21. Despite contemporary advances in understanding pathogenesis and effective management of gout, beliefs about the disease continue to be focused on gout as a self-inflicted illness. The illness label itself may ...

    Authors: Nicola Dalbeth, Meihana Douglas, Kate MacKrill, Leanne Te Karu, Maria Kleinstäuber and Keith J. Petrie

    Citation: BMC Rheumatology 2020 4:23

    Content type: Research article

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  22. Conservative, first-line treatments (exercise, education and weight-loss if appropriate) for hip and knee joint osteoarthritis are underused despite the known benefits. Clinicians’ beliefs can affect the advic...

    Authors: Daniel W. O’Brien, Sandra Bassett, Valerie Wright-St Clair and Richard J. Siegert

    Citation: BMC Rheumatology 2020 4:15

    Content type: Research article

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  23. Rheumatoid arthritis is the most common type of inflammatory arthritis affecting about 1% of the population. With the advent of disease-modifying anti-rheumatic drugs the disease can be well controlled in many...

    Authors: Nils Schubert, Tillmann Schill, Marlene Plüß and Peter Korsten

    Citation: BMC Rheumatology 2020 4:11

    Content type: Case report

    Published on:

  24. Despite high risk for cardiovascular disease (CVD) mortality, screening and treatment of hyperlipidemia in patients with rheumatoid arthritis (RA) is suboptimal. We asked primary care physicians (PCPs) and rhe...

    Authors: Iris Navarro-Millán, Anna Cornelius-Schecter, Ronan J. O’Beirne, Melanie S. Morris, Geyanne E. Lui, Susan M. Goodman, Andrea L. Cherrington, Liana Fraenkel, Jeffrey R. Curtis and Monika M. Safford

    Citation: BMC Rheumatology 2020 4:14

    Content type: Research article

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  25. Symptoms and comorbidities of ankylosing spondylitis (AS) considerably reduce health-related quality of life (HRQoL) and ability to work. This real-world study assessed rates of tumour necrosis factor inhibito...

    Authors: A. Deodhar, V. Strand, P. G. Conaghan, E. Sullivan, S. Blackburn, H. Tian, K. Gandhi, S. M. Jugl and R. Alten

    Citation: BMC Rheumatology 2020 4:19

    Content type: Research article

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  26. Strategic drug therapy for rheumatoid arthritis (RA) patients with prolonged remission is not well defined. According to recent guidelines, tapering biological Disease-Modifying Anti-Rheumatic Drugs (bDMARDs) ...

    Authors: Chayma Ladhari, Pierre Le Blay, Thierry Vincent, Ahmed Larbi, Emma Rubenstein, Rosanna Ferreira Lopez, Christian Jorgensen and Yves-Marie Pers

    Citation: BMC Rheumatology 2020 4:5

    Content type: Research article

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  27. Patients with rheumatoid arthritis (RA) have increased cardiovascular (CV) and mortality risk. Patients with RA are also frequently prescribed glucocorticoids (GCs) which have been associated with increased ri...

    Authors: Ruth E. Costello, Antonia Marsden, Mohammad Movahedi, Mark Lunt, Jenny H. Humphreys, Richard Emsley and William G. Dixon

    Citation: BMC Rheumatology 2020 4:4

    Content type: Research article

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  28. Peripheral ulcerative keratitis (PUK) is a severe inflammatory ocular disease that can affect patients with a long history of rheumatoid arthritis (RA). The use of biotherapy has revolutionized the treatment o...

    Authors: Sara Benchérifa, Bouchra Amine, Imane El Binoune, Samira Rostom and Rachid Bahiri

    Citation: BMC Rheumatology 2020 4:6

    Content type: Case report

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  29. Joint replacements continue to occur during a rheumatoid arthritis (RA) patient’s lifetime despite significant advances in available treatment options. The purpose of this study was to examine and quantify syn...

    Authors: Evan A. Choate, Gurjit S. Kaeley, Jenny Brook, Roy D. Altman, John D. FitzGerald, Astrid R. Floegel-Shetty, David A. Elashoff and Veena K. Ranganath

    Citation: BMC Rheumatology 2020 4:8

    Content type: Research article

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  30. S100A4 is a member of calcium binding S100 protein family well known for its role in cancer progression and metastasis. Nevertheless, S100A4 also serves as a negative regulator of bone formation. Dickkopf-1 (D...

    Authors: Barbora Šumová, Lucie Andrés Cerezo, Hana Hulejová, Klára Prajzlerová, Michal Tomčík, Kristýna Bubová, Jan Štěpán, Mária Filková, Tereza Kropáčková, Mariam Grigorian, Karel Pavelka, Jiří Vencovský and Ladislav Šenolt

    Citation: BMC Rheumatology 2020 4:13

    Content type: Research article

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  31. Relapsing polychondritis (RPC) is a rare progressive autoimmune disease characterized by inflammation in the cartilage of multiple organs. Tracheobronchial involvement appears in nearly half of RPC patients du...

    Authors: Tomonori Makiguchi, Akira Koarai, Chihiro Inoue, Yayoi Aoyama, Taizo Hirano, Takashi Ohe, Tomohiro Ichikawa, Yutaka Shishikura, Hanae Komuro, Yoko Tsukita, Naoki Tode, Tadahisa Numakura, Tsutomu Saito, Teruyuki Sato, Yoshiya Mitsuhashi, Tsutomu Tamada…

    Citation: BMC Rheumatology 2020 4:1

    Content type: Case report

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  32. A definite diagnosis of gout requires demonstration of monosodium urate crystals in synovial fluid or in tophi, which in clinical practice today seldom is done. Dual energy CT (DECT) has repeatedly been shown ...

    Authors: Elin Svensson, Ylva Aurell, Lennart T. H. Jacobsson, Anton Landgren, Valgerdur Sigurdardottir and Mats Dehlin

    Citation: BMC Rheumatology 2020 4:7

    Content type: Research article

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  33. While total joint replacements (TJR) are frequently performed, there is little qualitative research to define the outcomes most important to patients.

    Authors: Susan M. Goodman, Bella Mehta, Serene Z. Mirza, Mark P. Figgie, Michael Alexiades, Jose Rodriguez, Peter Sculco, Michael Parks and Jasvinder A. Singh

    Citation: BMC Rheumatology 2020 4:3

    Content type: Research article

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  34. There are limited real-world data on the diagnostic experiences of patients with psoriatic arthritis (PsA), including medical care sought and potential barriers to diagnosis. We aim to describe patient experie...

    Authors: Alexis Ogdie, W. Benjamin Nowell, Eddie Applegate, Kelly Gavigan, Shilpa Venkatachalam, Marie de la Cruz, Emuella Flood, Ethan J. Schwartz, Beverly Romero and Peter Hur

    Citation: BMC Rheumatology 2020 4:2

    Content type: Research article

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  35. Treatment decisions for any disease are usually informed by reference to published clinical guidelines or recommendations. These recommendations can be developed to improve the relative cost-effectiveness of h...

    Authors: Sean P. Gavan, Gavin Daker-White, Katherine Payne and Anne Barton

    Citation: BMC Rheumatology 2019 3:47

    Content type: Research article

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  36. To verify whether serum levels of reactive oxygen metabolites (ROM) are predictive of future clinical remission in patients with rheumatoid arthritis (RA) receiving tocilizumab (TCZ) therapy.

    Authors: Arata Nakajima, Keiichiro Terayama, Masato Sonobe, Yasuchika Aoki, Hiroshi Takahashi, Yorikazu Akatsu, Junya Saito, Shinji Taniguchi, Manabu Yamada, Ayako Kubota and Koichi Nakagawa

    Citation: BMC Rheumatology 2019 3:48

    Content type: Research article

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  37. The Health Assessment Questionnaire-Disability Index (HAQ-DI) is used to assess functional status in rheumatoid arthritis (RA), but the change required for meaningful improvements remains unclear. A minimum cl...

    Authors: Frank Behrens, Michaela Koehm, Eva C. Schwaneck, Marc Schmalzing, Holger Gnann, Gerd Greger, Hans-Peter Tony and Harald Burkhardt

    Citation: BMC Rheumatology 2019 3:51

    Content type: Research article

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  38. Patients with psoriatic arthritis (PsA) have increased risk of adverse events, including serious infections (SI), compared with psoriasis patients.

    Authors: Christopher T. Ritchlin, Mona Stahle, Yves Poulin, Jerry Bagel, Soumya D. Chakravarty, Shelly Kafka, Bhaskar Srivastava, Wayne Langholff and Alice B. Gottlieb

    Citation: BMC Rheumatology 2019 3:52

    Content type: Research article

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  39. There is an ongoing discussion about incorporating additional risk factors to established WHO fracture risk assessment tool (FRAX) to improve the prediction accuracy in clinical subgroups. We aimed to reach an...

    Authors: Nicolas S. Bodmer, Hans Jörg Häuselmann, Diana Frey, Daniel Aeberli and Lucas M. Bachmann

    Citation: BMC Rheumatology 2019 3:50

    Content type: Research article

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  42. The idiopathic inflammatory myopathies (IIMs) are a group of rare conditions characterised by muscle inflammation (myositis). Accurate disease activity assessment is vital in both clinical and research setting...

    Authors: Alexander Oldroyd, Max A. Little, William Dixon and Hector Chinoy

    Citation: BMC Rheumatology 2019 3:41

    Content type: Research article

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  43. Group B Streptococcus (GBS) emerged as the frequent pathogen for septic arthritis. There was no study comparing risks, clinical presentations and outcomes between GBS septic arthritis and other bacterial septi...

    Authors: Rungkan Ruksasakul, Pongthorn Narongroeknawin, Paijit Assavatanabodee and Sumapa Chaiamnuay

    Citation: BMC Rheumatology 2019 3:38

    Content type: Research article

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  44. Rheumatoid arthritis (RA) is associated with a 5 to 10 years reduction in life expectancy due to premature atherosclerosis. This reduction is the consequence of traditional cardiovascular risk factors (TCRF) a...

    Authors: Christophe Mulumba, Pierrot Lebughe, Jean-Marie Mbuyi-Muamba, Jean-Robert Makulo, François Lepira, Jean Mukaya, Rene Westhovens, Patrick Verschueren and Jean-Jacques Malemba

    Citation: BMC Rheumatology 2019 3:37

    Content type: Research article

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  45. Patient-reported outcomes (PROs) aid in rheumatoid arthritis (RA) management, but it is not well understood which measures would be most relevant to the rheumatologists for making treatment decisions.

    Authors: Aprajita Jagpal, Ronan O’Beirne, Melanie S. Morris, Bernadette Johnson, James Willig, Huifeng Yun, Andrea L. Cherrington, Liana Fraenkel, Jeffrey R. Curtis, Monika M. Safford and Iris Navarro-Millán

    Citation: BMC Rheumatology 2019 3:36

    Content type: Research article

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  46. To undertake a retrospective review of patients with SLE who had received Rituximab in order to determine the rates and associated patient characteristics of clinically significant adverse infusion reactions.

    Authors: Ashleigh Hennessey, Joanna Lukawska, Geraldine Cambridge, David Isenberg and Maria Leandro

    Citation: BMC Rheumatology 2019 3:32

    Content type: Research article

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  47. Hypogammaglobulinemia is a complication of B-cell targeting therapies (BCTT), used in vasculitis, rheumatoid arthritis and systemic lupus erythematosus (SLE). Since autoimmune diseases are associated with unde...

    Authors: M. J. Cuadrado, I. Calatayud, M. Urquizu-Padilla, S. Wijetilleka, S. Kiani-Alikhan and M. Y. Karim

    Citation: BMC Rheumatology 2019 3:30

    Content type: Research article

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  48. Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that primarily affects joints with some extraarticular involvement. If inappropriately treated, it usually results in persistent joint pain, i...

    Authors: Wanruchada Katchamart, Pongthorn Narongroeknawin, Wanwisa Chanapai and Phakhamon Thaweeratthakul

    Citation: BMC Rheumatology 2019 3:34

    Content type: Research article

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  50. Methods of gout flare reporting in research settings are inconsistent and poorly defined. The aim of this study was to describe patterns of gout flare and assess the concurrent validity of different methods of...

    Authors: Novell Teoh, Gregory D. Gamble, Anne Horne, William J. Taylor, Kate Palmano and Nicola Dalbeth

    Citation: BMC Rheumatology 2019 3:27

    Content type: Research article

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BMC Rheumatology

ISSN: 2520-1026

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