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Clinical rheumatology

This section is concerns all aspects of clinical rheumatology

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  1. Eosinophilic granulomatosis with polyangiitis (EGPA) is an anti-neutrophil antibody (ANCA)-associated necrotizing vasculitis, which predominantly affects small to medium vessels, and is associated with asthma ...

    Authors: Ken-ei Sada, Atsushi Miyauchi, Daisuke Hashimoto, Riku Ino, Shigeru Nojima, Shingo Yamanaka and Masafumi Kawamura

    Citation: BMC Rheumatology 2021 5:28

    Content type: Case report

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  2. Inflammation of patients joints with severe disease activity of rheumatoid arthritis (RA) has already been visualized and quantified by 2-[18F]fluoro-2-deoxy-D-glucose positron emission computed tomography ([18F]...

    Authors: Charline Rinkin, Pacôme Fosse, Olivier Malaise, Nathalie Chapelier, Jil Horrion, Laurence Seidel, Adelin Albert, Roland Hustinx and Michel G. Malaise

    Citation: BMC Rheumatology 2021 5:31

    Content type: Research article

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  3. Vasculitides comprise a group of rare diseases which affect less than 5 in 10.000 individuals. Most types of vasculitis can become organ- and life-threatening and are characterized by chronicity, high morbidit...

    Authors: Christof Iking-Konert, Pia Wallmeier, Sabrina Arnold, Sabine Adler, Kirsten de Groot, Bernhard Hellmich, Bimba F. Hoyer, Konstanze Holl-Ulrich, Gabriele Ihorst, Margit Kaufmann, Ina Kötter, Ulf Müller-Ladner, T. Magnus, Jürgen Rech, Fabian Schubach, Hendrik Schulze-Koops…

    Citation: BMC Rheumatology 2021 5:40

    Content type: Study protocol

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  4. Anti-synthetase syndrome is the collection of myositis and/or interstitial lung disease with the presence of various antibodies directed against an aminoacyl transfer RNA synthetase. Anti Jo − 1 antibody is th...

    Authors: C. T. Rosa, A. S. Thilakarathne, L. A. Senevirathne, A. Wijeyeratna and D. Munidasa

    Citation: BMC Rheumatology 2021 5:25

    Content type: Case report

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  5. Our knowledge of immune-mediated inflammatory disease (IMID) aetiology and pathogenesis has improved greatly over recent years, however, very little is known of the factors that trigger disease relapses (flare...

    Authors: Fiona Rayner, Amy E. Anderson, Kenneth F. Baker, Christopher D. Buckley, Bernard Dyke, Sally Fenton, Andrew Filer, Carl S. Goodyear, Catharien M. U. Hilkens, Shaun Hiu, Sean Kerrigan, Mariola Kurowska-Stolarska, Fiona Matthews, Iain McInnes, Wan-Fai Ng, Arthur G. Pratt…

    Citation: BMC Rheumatology 2021 5:22

    Content type: Study protocol

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  6. Pain and fatigue are persistent problems in people with rheumatoid arthritis. Central sensitisation (CS) may contribute to pain and fatigue, even when treatment has controlled inflammatory disease. This study ...

    Authors: Onosi S. Ifesemen, Daniel F. McWilliams, Eamonn Ferguson, Richard Wakefield, Kehinde Akin-Akinyosoye, Deborah Wilson, Dorothy Platts, Susan Ledbury and David A. Walsh

    Citation: BMC Rheumatology 2021 5:23

    Content type: Study protocol

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  7. Chronic Recurrent Multifocal Osteomyelitis (CRMO) is a condition characterized by sterile bone inflammation, usually occurring in childhood. Although the etiology remains unclear, this condition has been assoc...

    Authors: Hon Yan Ng, Orlee R. Guttman and Lori B. Tucker

    Citation: BMC Rheumatology 2021 5:16

    Content type: Case report

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  8. Polyarteritis nodosa is a type of vasculitis affecting medium- and small-sized arteries that has been associated with hepatitis B but does not have an established relationship with autoimmune hepatitis. Here w...

    Authors: Freda Kennedy, Rachel Kapelow, Bilge D. Kalyon, Nitzan C. Roth, Arvind Rishi and Maria-Louise Barilla-LaBarca

    Citation: BMC Rheumatology 2021 5:17

    Content type: Case report

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  9. Psoriatic arthritis (PsA) presents a unique clinical challenge. Affecting joints, skin, nails, and other organs, it is associated with various comorbidities and has a significant impact on quality of life, soc...

    Authors: Gareth T. Jones, Gary J. Macfarlane, Karen Forrest Keenan, Paul McNamee, Aileen R. Neilson, Stefan Siebert, A. David Burden, Lesley Kay and Philip S. Helliwell

    Citation: BMC Rheumatology 2021 5:19

    Content type: Study protocol

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  10. The self-reported Health Assessment Questionnaire (HAQ) is specifically designed to assess disability in arthritic patients. In many studies women report higher functional disability than men. The reasons for ...

    Authors: Sidona-Valentina Bala, Maria L. E. Andersson, Kristina Forslind, Björn Svensson and Ingiäld Hafström

    Citation: BMC Rheumatology 2021 5:13

    Content type: Research article

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  11. Adult onset Still’s disease (AOSD) is a rare inflammatory disorder that classically presents with high spiking fevers, evanescent rash, and arthritis. The diagnosis is one of exclusion and can be further compl...

    Authors: Arash Mollaeian, Jingjing Chen, Nina N. Chan, Gregory A. Nizialek and Christopher J. Haas

    Citation: BMC Rheumatology 2021 5:12

    Content type: Case report

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    The Correction to this article has been published in BMC Rheumatology 2021 5:29

  12. Patients with idiopathic inflammatory myopathy and autoantibodies directed against melanoma differentiation-associated protein 5 (MDA5) characteristically have interstitial lung disease, severe cutaneous invol...

    Authors: Meghan E. Ryan, Daniel Cortez, Kelly R. Dietz, Peter Karachunski and Bryce A. Binstadt

    Citation: BMC Rheumatology 2021 5:8

    Content type: Case report

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  13. Pyoderma gangrenosum (PG) is an uncommon, idiopathic, ulcerative neutrophilic dermatosis. In many cases, PG is associated with a wide variety of different disorders but SLE in association with PG is relatively...

    Authors: Sing Chiek Teoh, Chun Yang Sim, Seow Lin Chuah, Victoria Kok and Cheng Lay Teh

    Citation: BMC Rheumatology 2021 5:7

    Content type: Case report

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  14. Low dose methotrexate toxicity rarely occurs, but may present with severe complications, such as pancytopenia, hepatotoxicity, mucositis, and pneumonitis. Known risk factors for methotrexate toxicity include d...

    Authors: Miguel A. Jara-Palacios, William Chun and Nomi L. Traub

    Citation: BMC Rheumatology 2021 5:5

    Content type: Case report

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  15. Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that causes chronic synovitis, resulting in progressive joint destruction and functional disability and affects approximately 400,000 people in t...

    Authors: Ernest Choy, Lara Groves, Daniel Sugrue, Michael Hurst, John Houghton, Srinivasan Venkatachalam, Yusuf I. Patel, James R. Maxwell, Kevin G. Pollock and Sadie Henning

    Citation: BMC Rheumatology 2021 5:3

    Content type: Research article

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  16. Fictional portrayals of illness and medical management in film and television can reflect and perpetuate cultural stereotypes about illness. The aim of this study was to analyse fictional depictions of gout in...

    Authors: Christina Derksen, Rachel Murdoch, Keith J. Petrie and Nicola Dalbeth

    Citation: BMC Rheumatology 2021 5:4

    Content type: Research article

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  17. The diagnosis of Behçet disease (BD) is challenging in many cases. The purpose of this study was to describe the clinical characteristics of patients at a referral BD clinic.

    Authors: Mina Kiafar, Seyedeh Tahereh Faezi, Amir Kasaeian, Azarakhsh Baghdadi, Sahar Kakaei, Seyed Ali Mousavi, Mohammad Nejadhosseinian, Farhad Shahram, Seyedeh Zahra Ghodsi, Hormoz Shams and Fereydoun Davatchi

    Citation: BMC Rheumatology 2021 5:2

    Content type: Research article

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  18. Rheumatoid arthritis (RA) is characterized by systemic inflammation and bone and muscle loss. Recent research showed that obesity facilitates inflammation, but it is unknown if obesity also increases the risk ...

    Authors: Andreas Friedberger, Camille Figueiredo, Tobias Bäuerle, Georg Schett and Klaus Engelke

    Citation: BMC Rheumatology 2020 4:72

    Content type: Research article

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  19. Pain is the clinical hallmark of patients in patients with autoinflammatory diseases (AID) caused by variants of the NLRP3-, MEFV- or TNFRSF1A gene. However, no systematical analysis of the clinical and psycholog...

    Authors: Elisabeth Mulazzani, Nicole Zolyniak, Elisabeth Noe, Matthias Mulazzani, Shahnaz Christina Azad, Tania Kümpfel and Eduard Kraft

    Citation: BMC Rheumatology 2020 4:71

    Content type: Research article

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  20. Antineutrophil cytoplasmic antibodies (ANCA) and Anti-glomerular basement membrane (GBM) antibodies often induce rapidly progressive glomerulonephritis (RPGN). Some reports have demonstrated RPGN with the sequ...

    Authors: Mikiya Kato, Risa Wakiya, Tomohiro Kameda, Kousuke Inoue, Tadashi Sofue, Yusuke Ushio, Koichi Sugihara, Shusaku Nakashima, Hiromi Shimada, Mai Mahmoud Fahmy Mansour, Norimitsu Kadowaki and Hiroaki Dobashi

    Citation: BMC Rheumatology 2020 4:68

    Content type: Case report

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  21. Takayasu’s arteritis (TA) is a granulomatous, large vessel vasculitis with a preponderance for young women. The inflammation results in disruption of the arterial endothelium causing stenosis, endoluminal thro...

    Authors: Shania Niromi Gunasekera, Chirath Madurapperuma, Nilusha Weerasooriya, Harindra Karunathilake and Ananda Jayanaga

    Citation: BMC Rheumatology 2020 4:66

    Content type: Case report

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  22. Patients with rheumatoid arthritis (RA) have high mortality risk and are frequently treated in intensive care units (ICUs).

    Authors: Toshifumi Fujiwara, Kentaro Tokuda, Kenta Momii, Kyohei Shiomoto, Hidetoshi Tsushima, Yukio Akasaki, Satoshi Ikemura, Jun-ichi Fukushi, Jun Maki, Noriyuki Kaku, Tomohiko Akahoshi, Tomoaki Taguchi and Yasuharu Nakashima

    Citation: BMC Rheumatology 2020 4:64

    Content type: Research article

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  23. Vascular cell adhesion molecule-1 (VCAM-1) is involved in the progression of glomerular and tubulointerstitial injury in lupus nephritis (LN) and can be easily assessed in urine. The aim of this study was to a...

    Authors: Andrese Aline Gasparin, Nicole Pamplona Bueno de Andrade, Vanessa Hax, Penélope Esther Palominos, Marina Siebert, Romulo Marx, Pedro Guilherme Schaefer, Francisco Veríssimo Veronese and Odirlei André Monticielo

    Citation: BMC Rheumatology 2020 4:67

    Content type: Research article

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  24. The mixed cryoglobulinemia (MC) syndrome is a systemic inflammatory syndrome that causes small-to-medium vessel vasculitis due to cryoglobulin-containing immune complexes most commonly caused by chronic hepati...

    Authors: Nasam Alfraji, Vandan D. Upadhyaya, Christopher Bekampis and Halyna Kuzyshyn

    Citation: BMC Rheumatology 2020 4:58

    Content type: Case report

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  25. The objectives of this study were to describe the profile of ankylosing spondylitis (AS) patients treated with either infliximab (IFX) or subcutaneous golimumab (GLM) treatment in Canadian routine care setting...

    Authors: Proton Rahman, Michael Starr, Derek Haaland, Louis Bessette, Michelle Teo, Emmanouil Rampakakis, Allen J. Lehman and Francois Nantel

    Citation: BMC Rheumatology 2020 4:56

    Content type: Research article

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  26. Psoriasis is a chronic inflammatory disease of the skin affecting 2–3% of UK population. 30% of people affected by psoriasis will develop a distinct form of arthritis within 10 years of the skin condition onse...

    Authors: Jesus Miguens Blanco, Federica Borghese, Neil McHugh, Peter Kelleher, Raj Sengupta, Julian R. Marchesi and Sonya Abraham

    Citation: BMC Rheumatology 2020 4:60

    Content type: Study protocol

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  27. The B cell chemoattractant CXCL13 is a promising biomarker in rheumatoid arthritis (RA), with a plausible role in supporting diagnosis, monitoring disease activity and as a prognostic value. It is a key chemok...

    Authors: Katie Bechman, Anthony Dalrymple, Charles Southey-Bassols, Andrew P. Cope and James B. Galloway

    Citation: BMC Rheumatology 2020 4:70

    Content type: Research article

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  28. Different proportions of musculoskeletal or autoimmune manifestations associated with COVID-19 have been reported in literature. We performed a systematic review and meta-analysis with the aim of assessing the...

    Authors: Jacopo Ciaffi, Riccardo Meliconi, Piero Ruscitti, Onorina Berardicurti, Roberto Giacomelli and Francesco Ursini

    Citation: BMC Rheumatology 2020 4:65

    Content type: Research article

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  29. Many patients with rheumatoid arthritis (RA) do not attain remission/low disease activity, remaining in a moderate disease activity state (MDAS) with ongoing disability and impaired quality of life (QoL). If p...

    Authors: Ian C. Scott, Julie Mount, Jane Barry and Bruce Kirkham

    Citation: BMC Rheumatology 2020 4:63

    Content type: Research article

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  30. Musculoskeletal ultrasound (MSUS) and the multi-biomarker disease activity (MBDA) score are outcome measures that may aid in the management of rheumatoid arthritis (RA) patients. This study evaluated tofacitin...

    Authors: Amir A. Razmjou, Jenny Brook, David Elashoff, Gurjit Kaeley, Soo Choi, Tanaz Kermani and Veena K. Ranganath

    Citation: BMC Rheumatology 2020 4:55

    Content type: Research article

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  31. Blood accessible biomarkers to assess disease activity and their response to therapies in Juvenile Dermatomyositis (JDM) are urgently needed. This pilot study aims to identify serum protein biomarkers associat...

    Authors: Shefa M. Tawalbeh, Wilfredo Marin, Gabrielle A. Morgan, Utkarsh J. Dang, Yetrib Hathout and Lauren M. Pachman

    Citation: BMC Rheumatology 2020 4:52

    Content type: Research article

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  32. Long-term clinical registries are essential tools to evaluate new therapies in a patient population that differs from those in randomized clinical trials. The objectives are to describe the profile of rheumato...

    Authors: Proton Rahman, Philip Baer, Ed Keystone, Denis Choquette, Carter Thorne, Boulos Haraoui, Andrew Chow, Rafat Faraawi, Wojciech Olszynski, John Kelsall, Emmanouil Rampakakis, Allen J. Lehman and Francois Nantel

    Citation: BMC Rheumatology 2020 4:46

    Content type: Research article

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  33. Cases of exacerbation of pre-existing neuromuscular diseases induced by immune checkpoint inhibitors (ICIs) have rarely been reported because patients with autoimmune diseases have generally been excluded from...

    Authors: Naohiro Uchio, Atsushi Unuma, Toshiyuki Kakumoto, Masao Osaki, Yoshitaka Zenke, Kenichi Sakuta, Akatsuki Kubota, Yoshikazu Uesaka, Tatsushi Toda and Jun Shimizu

    Citation: BMC Rheumatology 2020 4:48

    Content type: Case report

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  34. To determine whether initiation of a tumor necrosis factor inhibitor (TNFi) or methotrexate improves hemoglobin A1c in patients with psoriatic arthritis (PsA), rheumatoid arthritis (RA), or ankylosing spondyli...

    Authors: Santhi Mantravadi, Michael George, Colleen Brensinger, Min Du, Joshua F. Baker and Alexis Ogdie

    Citation: BMC Rheumatology 2020 4:39

    Content type: Research article

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  35. Proteasomes are found in both the cell nucleus and cytoplasm and play a major role in the ubiquitin-dependent and -independent non-lysosomal pathways of intracellular protein degradation. Proteasomes are also ...

    Authors: Hiroshi Maruyama, Kouichi Hirayama, Marina Yamashita, Kentaro Ohgi, Ryuji Tsujimoto, Mamiko Takayasu, Homare Shimohata and Masaki Kobayashi

    Citation: BMC Rheumatology 2020 4:36

    Content type: Research article

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  36. Giant cell arteritis (GCA) is a common large vessel vasculitis of the elderly, often associated with sight loss. Glucocorticoids (GC remain the mainstay of treatment, although biologic treatments have been app...

    Authors: Alwin Sebastian, Kornelis S. M. van der Geest, Fiona Coath, Prisca Gondo, Abdul Kayani, Craig Mackerness, Bernard Hadebe, Sue Innes, Jo Jackson and Bhaskar Dasgupta

    Citation: BMC Rheumatology 2020 4:35

    Content type: Study protocol

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  37. Retroperitoneal fibrosis (RPF) is characterized by the proliferation of fibrous tissue in the retroperitoneum. The majority of RPF cases are due to idiopathic or IgG4-related disease. Recent studies on IgG4-re...

    Authors: Veronika Boyeva, Hatim Alabsi, Michael A. Seidman, Ryan Paterson, Jason Kur, Luke Y. C. Chen, Silvia D. Chang and Mollie Carruthers

    Citation: BMC Rheumatology 2020 4:40

    Content type: Research article

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  38. Patients treated for cancer with immune checkpoint inhibitors (ICI) may develop autoimmune adverse events, including ICI-induced inflammatory arthritis (IA). ICI-induced IA treatment requires balancing immune ...

    Authors: Laura C. Cappelli, Suzanne M. Grieb, Ami A. Shah, Clifton O. Bingham III and Ana-Maria Orbai

    Citation: BMC Rheumatology 2020 4:32

    Content type: Research article

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  39. To gain insight in the use of current systemic sclerosis (SSc) care provided by health professionals from the patient perspective. We focused on referral reasons, treatment goals, the alignment with unmet care...

    Authors: Juliane K. Stöcker, Madelon C. Vonk, Frank H. J. van den Hoogen, Maria W. G. Nijhuis-van der Sanden, Julia Spierings, J. Bart Staal, Ton Satink and Cornelia H. M. van den Ende

    Citation: BMC Rheumatology 2020 4:43

    Content type: Research article

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  40. Dose loading of biological disease modifying anti-rheumatic drugs (bDMARDs) in auto-immune rheumatic diseases (AIRDs) is performed to achieve steady state drug concentrations earlier after treatment start comp...

    Authors: Gerlienke E. Geurts-Voerman, Lise M. Verhoef, Bart J. F. van den Bemt and Alfons A. den Broeder

    Citation: BMC Rheumatology 2020 4:37

    Content type: Research article

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  41. Previous studies have linked rheumatoid arthritis (RA) risk and disease activity with vitamin D-deficiency (low serum 25-hydroxyvitamin D (25OHD)), but a causal role for vitamin D in RA is still unclear, with ...

    Authors: Stephanie R. Harrison, Gurpreet Jutley, Danyang Li, Ilfita Sahbudin, Andrew Filer, Martin Hewison and Karim Raza

    Citation: BMC Rheumatology 2020 4:38

    Content type: Research article

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  42. Line blot immunoassays (LIA) for myositis-specific (MSA) and myositis-associated (MAA) autoantibodies have become commercially available. In the largest study of this kind, we evaluated the clinical performanc...

    Authors: Fergus To, Clara Ventín-Rodríguez, Shuayb Elkhalifa, James B. Lilleker and Hector Chinoy

    Citation: BMC Rheumatology 2020 4:28

    Content type: Research article

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  43. Inflammatory Arthritis is characterized by lifelong medical treatment and an unpredictable trajectory because of the fluctuating nature of the diseases. Proactive disease management is recommended, which inclu...

    Authors: Bianca Bech, Jens Jørgen Lykkegaard, Tine Lundbak, Heidi Morsø Schrøder, Line Mette Birkeland, Mette Lund Schlyter, Lotte Hanne Hansen, Lillian Dalsgaard and Bente Appel Esbensen

    Citation: BMC Rheumatology 2020 4:44

    Content type: Research article

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  44. Immune-mediated necrotising myopathy (IMNM) is characterised by severe muscle weakness and necrosis with a paucity of inflammation on muscle biopsy. Around 60% of cases are associated with antibodies to the si...

    Authors: Rhys Thomas, Su-Ann Yeoh, Rupert Berkeley, Andrew Woods, Mike Stevens, Silvia Marino and Aleksandar Radunovic

    Citation: BMC Rheumatology 2020 4:29

    Content type: Case report

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