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Clinical rheumatology

Section edited by Susan Goodman (New York, US)

This section is concerns all aspects of clinical rheumatology

Page 1 of 2

  1. Inflammatory Arthritis is characterized by lifelong medical treatment and an unpredictable trajectory because of the fluctuating nature of the diseases. Proactive disease management is recommended, which inclu...

    Authors: Bianca Bech, Jens Jørgen Lykkegaard, Tine Lundbak, Heidi Morsø Schrøder, Line Mette Birkeland, Mette Lund Schlyter, Lotte Hanne Hansen, Lillian Dalsgaard and Bente Appel Esbensen

    Citation: BMC Rheumatology 2020 4:44

    Content type: Research article

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  2. Immune-mediated necrotising myopathy (IMNM) is characterised by severe muscle weakness and necrosis with a paucity of inflammation on muscle biopsy. Around 60% of cases are associated with antibodies to the si...

    Authors: Rhys Thomas, Su-Ann Yeoh, Rupert Berkeley, Andrew Woods, Mike Stevens, Silvia Marino and Aleksandar Radunovic

    Citation: BMC Rheumatology 2020 4:29

    Content type: Case report

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  3. It is plausible that optimal cardiovascular disease (CVD) risk management differs in patients with rheumatoid arthritis (RA) from low or middle income compared to high income populations. This study aimed at p...

    Authors: Ahmed Solomon, Anne E. Stanwix, Santos Castañeda, Javier Llorca, Carlos Gonzalez-Juanatey, Bridget Hodkinson, Benitha Romela, Mahmood M. T. M. Ally, Ajesh B. Maharaj, Elsa M. Van Duuren, Joyce J. Ziki, Mpoti Seboka, Makgotso Mohapi, Barend J. Jansen Van Rensburg, Gareth S. Tarr, Kavita Makan…

    Citation: BMC Rheumatology 2020 4:42

    Content type: Research article

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  4. Disease-modifying antirheumatic drugs (DMARDs) have transformed the treatment of numerous autoimmune and inflammatory diseases but their perceived risk of harm may be a barrier to use.

    Authors: Hiba EL Masri, Samantha A. Hollingworth, Mieke van Driel, Helen Benham and Treasure M. McGuire

    Citation: BMC Rheumatology 2020 4:27

    Content type: Research article

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  5. Our study aimed to compare efficacy and safety of Hetero’s adalimumab (Mabura®, Hetero Biopharma Limited) versus reference adalimumab (Humira®, Abbvie Inc.) in Indian patients with active rheumatoid arthritis ...

    Authors: Shubhadeep Sinha, Biswadip Ghosh, Syamasis Bandyopadhyay, Firdaus Fatima, Vamsi Krishna Bandi, Pankaj Thakur, Bala Reddy, Sreenivasa Chary, Leela Talluri, Ajay Gupta, Amit Ramchandra Kale, Anil Kumar Gupta, Ashok Kumar P, Diwakar Reddy, Younus Mohammed, Soma Shekar…

    Citation: BMC Rheumatology 2020 4:24

    Content type: Research article

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  6. In this commentary, we discuss the potential of advanced imaging, particularly Dynamic Contrast Enhanced (DCE) magnetic resonance imaging (MRI) for the objective assessment of the inflammatory process in rheum...

    Authors: Ali Mobasheri, Mark Hinton, Faiq Shaikh and Olga Kubassova

    Citation: BMC Rheumatology 2020 4:33

    Content type: Commentary

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  7. Severe spinal pain is an unusual presentation of gout. Due to its rarity and the difficulty of obtaining joint fluid or tissue for crystal analysis, dual energy computed tomography (DECT) may be a useful imagi...

    Authors: Jeremy X. Wang, Beverly Ng, Haesung Bak, David Spencer, Nicholas Manolios and Peter K. K. Wong

    Citation: BMC Rheumatology 2020 4:22

    Content type: Case report

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  8. Various inflammatory conditions may present with musculoskeletal symptoms similar to those of polymyalgia rheumatica (PMR). We investigated findings on 18F-fluorodexoxyglucose (FDG)-positron emission tomography/c...

    Authors: Hideyuki Horikoshi, Takashi Nakanishi, Katsumi Tamura, Fumihiko Kimura and Kenji Itoh

    Citation: BMC Rheumatology 2020 4:21

    Content type: Research article

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  9. Despite contemporary advances in understanding pathogenesis and effective management of gout, beliefs about the disease continue to be focused on gout as a self-inflicted illness. The illness label itself may ...

    Authors: Nicola Dalbeth, Meihana Douglas, Kate MacKrill, Leanne Te Karu, Maria Kleinstäuber and Keith J. Petrie

    Citation: BMC Rheumatology 2020 4:23

    Content type: Research article

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  10. Conservative, first-line treatments (exercise, education and weight-loss if appropriate) for hip and knee joint osteoarthritis are underused despite the known benefits. Clinicians’ beliefs can affect the advic...

    Authors: Daniel W. O’Brien, Sandra Bassett, Valerie Wright-St Clair and Richard J. Siegert

    Citation: BMC Rheumatology 2020 4:15

    Content type: Research article

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  11. Rheumatoid arthritis is the most common type of inflammatory arthritis affecting about 1% of the population. With the advent of disease-modifying anti-rheumatic drugs the disease can be well controlled in many...

    Authors: Nils Schubert, Tillmann Schill, Marlene Plüß and Peter Korsten

    Citation: BMC Rheumatology 2020 4:11

    Content type: Case report

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  12. Despite high risk for cardiovascular disease (CVD) mortality, screening and treatment of hyperlipidemia in patients with rheumatoid arthritis (RA) is suboptimal. We asked primary care physicians (PCPs) and rhe...

    Authors: Iris Navarro-Millán, Anna Cornelius-Schecter, Ronan J. O’Beirne, Melanie S. Morris, Geyanne E. Lui, Susan M. Goodman, Andrea L. Cherrington, Liana Fraenkel, Jeffrey R. Curtis and Monika M. Safford

    Citation: BMC Rheumatology 2020 4:14

    Content type: Research article

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  13. Symptoms and comorbidities of ankylosing spondylitis (AS) considerably reduce health-related quality of life (HRQoL) and ability to work. This real-world study assessed rates of tumour necrosis factor inhibito...

    Authors: A. Deodhar, V. Strand, P. G. Conaghan, E. Sullivan, S. Blackburn, H. Tian, K. Gandhi, S. M. Jugl and R. Alten

    Citation: BMC Rheumatology 2020 4:19

    Content type: Research article

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  14. Strategic drug therapy for rheumatoid arthritis (RA) patients with prolonged remission is not well defined. According to recent guidelines, tapering biological Disease-Modifying Anti-Rheumatic Drugs (bDMARDs) ...

    Authors: Chayma Ladhari, Pierre Le Blay, Thierry Vincent, Ahmed Larbi, Emma Rubenstein, Rosanna Ferreira Lopez, Christian Jorgensen and Yves-Marie Pers

    Citation: BMC Rheumatology 2020 4:5

    Content type: Research article

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  15. Patients with rheumatoid arthritis (RA) have increased cardiovascular (CV) and mortality risk. Patients with RA are also frequently prescribed glucocorticoids (GCs) which have been associated with increased ri...

    Authors: Ruth E. Costello, Antonia Marsden, Mohammad Movahedi, Mark Lunt, Jenny H. Humphreys, Richard Emsley and William G. Dixon

    Citation: BMC Rheumatology 2020 4:4

    Content type: Research article

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  16. Peripheral ulcerative keratitis (PUK) is a severe inflammatory ocular disease that can affect patients with a long history of rheumatoid arthritis (RA). The use of biotherapy has revolutionized the treatment o...

    Authors: Sara Benchérifa, Bouchra Amine, Imane El Binoune, Samira Rostom and Rachid Bahiri

    Citation: BMC Rheumatology 2020 4:6

    Content type: Case report

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  17. Joint replacements continue to occur during a rheumatoid arthritis (RA) patient’s lifetime despite significant advances in available treatment options. The purpose of this study was to examine and quantify syn...

    Authors: Evan A. Choate, Gurjit S. Kaeley, Jenny Brook, Roy D. Altman, John D. FitzGerald, Astrid R. Floegel-Shetty, David A. Elashoff and Veena K. Ranganath

    Citation: BMC Rheumatology 2020 4:8

    Content type: Research article

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  18. S100A4 is a member of calcium binding S100 protein family well known for its role in cancer progression and metastasis. Nevertheless, S100A4 also serves as a negative regulator of bone formation. Dickkopf-1 (D...

    Authors: Barbora Šumová, Lucie Andrés Cerezo, Hana Hulejová, Klára Prajzlerová, Michal Tomčík, Kristýna Bubová, Jan Štěpán, Mária Filková, Tereza Kropáčková, Mariam Grigorian, Karel Pavelka, Jiří Vencovský and Ladislav Šenolt

    Citation: BMC Rheumatology 2020 4:13

    Content type: Research article

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  19. Relapsing polychondritis (RPC) is a rare progressive autoimmune disease characterized by inflammation in the cartilage of multiple organs. Tracheobronchial involvement appears in nearly half of RPC patients du...

    Authors: Tomonori Makiguchi, Akira Koarai, Chihiro Inoue, Yayoi Aoyama, Taizo Hirano, Takashi Ohe, Tomohiro Ichikawa, Yutaka Shishikura, Hanae Komuro, Yoko Tsukita, Naoki Tode, Tadahisa Numakura, Tsutomu Saito, Teruyuki Sato, Yoshiya Mitsuhashi, Tsutomu Tamada…

    Citation: BMC Rheumatology 2020 4:1

    Content type: Case report

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  20. A definite diagnosis of gout requires demonstration of monosodium urate crystals in synovial fluid or in tophi, which in clinical practice today seldom is done. Dual energy CT (DECT) has repeatedly been shown ...

    Authors: Elin Svensson, Ylva Aurell, Lennart T. H. Jacobsson, Anton Landgren, Valgerdur Sigurdardottir and Mats Dehlin

    Citation: BMC Rheumatology 2020 4:7

    Content type: Research article

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  21. While total joint replacements (TJR) are frequently performed, there is little qualitative research to define the outcomes most important to patients.

    Authors: Susan M. Goodman, Bella Mehta, Serene Z. Mirza, Mark P. Figgie, Michael Alexiades, Jose Rodriguez, Peter Sculco, Michael Parks and Jasvinder A. Singh

    Citation: BMC Rheumatology 2020 4:3

    Content type: Research article

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  22. There are limited real-world data on the diagnostic experiences of patients with psoriatic arthritis (PsA), including medical care sought and potential barriers to diagnosis. We aim to describe patient experie...

    Authors: Alexis Ogdie, W. Benjamin Nowell, Eddie Applegate, Kelly Gavigan, Shilpa Venkatachalam, Marie de la Cruz, Emuella Flood, Ethan J. Schwartz, Beverly Romero and Peter Hur

    Citation: BMC Rheumatology 2020 4:2

    Content type: Research article

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  23. Treatment decisions for any disease are usually informed by reference to published clinical guidelines or recommendations. These recommendations can be developed to improve the relative cost-effectiveness of h...

    Authors: Sean P. Gavan, Gavin Daker-White, Katherine Payne and Anne Barton

    Citation: BMC Rheumatology 2019 3:47

    Content type: Research article

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  24. To verify whether serum levels of reactive oxygen metabolites (ROM) are predictive of future clinical remission in patients with rheumatoid arthritis (RA) receiving tocilizumab (TCZ) therapy.

    Authors: Arata Nakajima, Keiichiro Terayama, Masato Sonobe, Yasuchika Aoki, Hiroshi Takahashi, Yorikazu Akatsu, Junya Saito, Shinji Taniguchi, Manabu Yamada, Ayako Kubota and Koichi Nakagawa

    Citation: BMC Rheumatology 2019 3:48

    Content type: Research article

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  25. The Health Assessment Questionnaire-Disability Index (HAQ-DI) is used to assess functional status in rheumatoid arthritis (RA), but the change required for meaningful improvements remains unclear. A minimum cl...

    Authors: Frank Behrens, Michaela Koehm, Eva C. Schwaneck, Marc Schmalzing, Holger Gnann, Gerd Greger, Hans-Peter Tony and Harald Burkhardt

    Citation: BMC Rheumatology 2019 3:51

    Content type: Research article

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  26. Patients with psoriatic arthritis (PsA) have increased risk of adverse events, including serious infections (SI), compared with psoriasis patients.

    Authors: Christopher T. Ritchlin, Mona Stahle, Yves Poulin, Jerry Bagel, Soumya D. Chakravarty, Shelly Kafka, Bhaskar Srivastava, Wayne Langholff and Alice B. Gottlieb

    Citation: BMC Rheumatology 2019 3:52

    Content type: Research article

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  27. There is an ongoing discussion about incorporating additional risk factors to established WHO fracture risk assessment tool (FRAX) to improve the prediction accuracy in clinical subgroups. We aimed to reach an...

    Authors: Nicolas S. Bodmer, Hans Jörg Häuselmann, Diana Frey, Daniel Aeberli and Lucas M. Bachmann

    Citation: BMC Rheumatology 2019 3:50

    Content type: Research article

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  28. The idiopathic inflammatory myopathies (IIMs) are a group of rare conditions characterised by muscle inflammation (myositis). Accurate disease activity assessment is vital in both clinical and research setting...

    Authors: Alexander Oldroyd, Max A. Little, William Dixon and Hector Chinoy

    Citation: BMC Rheumatology 2019 3:41

    Content type: Research article

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  29. Group B Streptococcus (GBS) emerged as the frequent pathogen for septic arthritis. There was no study comparing risks, clinical presentations and outcomes between GBS septic arthritis and other bacterial septi...

    Authors: Rungkan Ruksasakul, Pongthorn Narongroeknawin, Paijit Assavatanabodee and Sumapa Chaiamnuay

    Citation: BMC Rheumatology 2019 3:38

    Content type: Research article

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  30. Rheumatoid arthritis (RA) is associated with a 5 to 10 years reduction in life expectancy due to premature atherosclerosis. This reduction is the consequence of traditional cardiovascular risk factors (TCRF) a...

    Authors: Christophe Mulumba, Pierrot Lebughe, Jean-Marie Mbuyi-Muamba, Jean-Robert Makulo, François Lepira, Jean Mukaya, Rene Westhovens, Patrick Verschueren and Jean-Jacques Malemba

    Citation: BMC Rheumatology 2019 3:37

    Content type: Research article

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  31. Patient-reported outcomes (PROs) aid in rheumatoid arthritis (RA) management, but it is not well understood which measures would be most relevant to the rheumatologists for making treatment decisions.

    Authors: Aprajita Jagpal, Ronan O’Beirne, Melanie S. Morris, Bernadette Johnson, James Willig, Huifeng Yun, Andrea L. Cherrington, Liana Fraenkel, Jeffrey R. Curtis, Monika M. Safford and Iris Navarro-Millán

    Citation: BMC Rheumatology 2019 3:36

    Content type: Research article

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  32. To undertake a retrospective review of patients with SLE who had received Rituximab in order to determine the rates and associated patient characteristics of clinically significant adverse infusion reactions.

    Authors: Ashleigh Hennessey, Joanna Lukawska, Geraldine Cambridge, David Isenberg and Maria Leandro

    Citation: BMC Rheumatology 2019 3:32

    Content type: Research article

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  33. Hypogammaglobulinemia is a complication of B-cell targeting therapies (BCTT), used in vasculitis, rheumatoid arthritis and systemic lupus erythematosus (SLE). Since autoimmune diseases are associated with unde...

    Authors: M. J. Cuadrado, I. Calatayud, M. Urquizu-Padilla, S. Wijetilleka, S. Kiani-Alikhan and M. Y. Karim

    Citation: BMC Rheumatology 2019 3:30

    Content type: Research article

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  34. Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that primarily affects joints with some extraarticular involvement. If inappropriately treated, it usually results in persistent joint pain, i...

    Authors: Wanruchada Katchamart, Pongthorn Narongroeknawin, Wanwisa Chanapai and Phakhamon Thaweeratthakul

    Citation: BMC Rheumatology 2019 3:34

    Content type: Research article

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  35. Methods of gout flare reporting in research settings are inconsistent and poorly defined. The aim of this study was to describe patterns of gout flare and assess the concurrent validity of different methods of...

    Authors: Novell Teoh, Gregory D. Gamble, Anne Horne, William J. Taylor, Kate Palmano and Nicola Dalbeth

    Citation: BMC Rheumatology 2019 3:27

    Content type: Research article

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  36. Heterogeneity in assessments of rheumatoid arthritis (RA) disease remission, based on physician judgment and patient self-reports versus standardized measures, have previously been reported. This study explore...

    Authors: Wenhui Wei, Emma Sullivan, Stuart Blackburn, Chieh-I Chen, James Piercy and Jeffrey R. Curtis

    Citation: BMC Rheumatology 2019 3:25

    Content type: Research article

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  37. Previous studies of prognosis for women with Fibromyalgia (FM) or chronic widespread pain (CWP) show contradictory results. However, some women appear to improve in pain and other core symptoms over time. Ther...

    Authors: Anna Bergenheim, Sofia Juhlin, Lena Nordeman, Monica Joelsson and Kaisa Mannerkorpi

    Citation: BMC Rheumatology 2019 3:21

    Content type: Research article

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    The Publisher Correction to this article has been published in BMC Rheumatology 2019 3:35

  38. Withdrawal of disease-modifying anti-rheumatic drugs (DMARDs) once disease remission is achieved is endorsed by current international rheumatoid arthritis (RA) management guidelines. However, very little data ...

    Authors: Kenneth F. Baker, John D. Isaacs and Ben Thompson

    Citation: BMC Rheumatology 2019 3:24

    Content type: Research article

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    The Publisher Correction to this article has been published in BMC Rheumatology 2019 3:35

  39. The aim of this study was to identify predictors of prolonged disease control after discontinuation of tumor necrosis factor inhibitor (TNFi) treatment in patients with rheumatoid arthritis (RA).

    Authors: Marjan Ghiti Moghadam, Femke B. G. Lamers-Karnebeek, Harald E. Vonkeman, Peter M. ten Klooster, Janneke Tekstra, Barbara van Schaeybroeck, Ruth Klaasen, Marieke van Onna, Hein J. Bernelot Moens, Henk Visser, Annemarie M. Schilder, Marc R. Kok, Robert B. M. Landewé, Piet L. C. M. van Riel, Mart A. F. J. van de Laar and Tim L. Jansen

    Citation: BMC Rheumatology 2019 3:22

    Content type: Research article

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    The Publisher Correction to this article has been published in BMC Rheumatology 2019 3:35

  40. A fatty corner lesion (FCL) is a well-demarcated fat infiltration in the corner of a vertebral body on T1 magnetic resonance imaging (MRI) sequence. It has been reported to be useful in the diagnosis of axial ...

    Authors: Ho Yin Chung, Rachel Sze Wan Yiu, Shirley Chiu Wai Chan, Kam Ho Lee and Chak Sing Lau

    Citation: BMC Rheumatology 2019 3:17

    Content type: Research article

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  41. Around 1 in 8 patients with axial spondyloarthritis (axSpA) also meet criteria for fibromyalgia and such patients have considerable unmet need. Identifying effective therapy is important but to what extent fib...

    Authors: Gary J. Macfarlane, Ejaz Pathan, Stefan Siebert, Jonathan Packham, Karl Gaffney, Ernest Choy, Raj Sengupta, Fabiola Atzeni, Kathryn R. Martin, Gareth T. Jones and Linda E. Dean

    Citation: BMC Rheumatology 2019 3:19

    Content type: Research article

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  42. The details of two rheumatoid arthritis (RA) patients with systemic sclerosis (SSc) who were administered tocilizumab, an anti-interleukin-6 receptor antibody, are reported, along with a review of the literature.

    Authors: Hiroki Wakabayashi, Hitoshi Kino, Makoto Kondo, Keiichi Yamanaka, Masahiro Hasegawa and Akihiro Sudo

    Citation: BMC Rheumatology 2019 3:15

    Content type: Case report

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  43. The pathobiology of rheumatoid arthritis (RA) is similar to that of periodontitis in that proinflammatory cytokines play an important pathologic role. There is evidence to suggest that inhibitors of tumor necr...

    Authors: Tetsuo Kobayashi, Satoshi Ito, Akira Murasawa, Hajime Ishikawa and Hiromasa Yoshie

    Citation: BMC Rheumatology 2019 3:13

    Content type: Case report

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  44. The TITRATE trial seeks to test whether intensive management is valuable in achieving disease remission in moderately active rheumatoid arthritis. Intensive management is a complex intervention consisting of: ...

    Authors: Louise Prothero, Jackie Sturt, Savia de Souza and Heidi Lempp

    Citation: BMC Rheumatology 2019 3:12

    Content type: Research article

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  45. Inhibitors of tumor necrosis factor alpha (TNF-α) are current mainstay of therapies for rheumatoid arthritis (RA). The decision when to withdraw TNF-α inhibitors after achieving remission and the incidence of ...

    Authors: Arduino A. Mangoni, Fahdah Al Okaily, Hani Almoallim, Seham Al Rashidi, Reem Hamdy A. Mohammed and Amal Barbary

    Citation: BMC Rheumatology 2019 3:10

    Content type: Research article

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