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Pre-clinical and translational science

Section edited by Alessia Alunno (Perugia, Italy)

This section concerns all aspects of pre-clinical and translational research in rheumatology covering a wide range of methodologies and study designs, including the identification of the molecular underpinnings of disease and the application of this knowledge for the discovery of new drug targets or for patient stratification.

  1. The idiopathic inflammatory myopathies (IIMs) are heterogeneous autoimmune conditions of skeletal muscle inflammation and weakness. MicroRNAs (miRNAs) are short, non-coding RNA which regulate gene expression o...

    Authors: Joanna E. Parkes, Anastasia Thoma, Adam P. Lightfoot, Philip J. Day, Hector Chinoy and Janine A. Lamb

    Citation: BMC Rheumatology 2020 4:25

    Content type: Research article

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  2. Patients with inflammatory arthritis (IA), defined as rheumatoid arthritis (RA) and psoriatic arthritis (PsA), are at increased risk for cardiovascular disease (CVD). The frequency of screening and treatment o...

    Authors: Iris Navarro-Millán, Sarah R. Young, Sally Shurbaji, Chastity McDavid, Anna Cornelius-Schecter, Bernadette Johnson, Andrea L. Cherrington, Liana Fraenkel, Susan M. Goodman, Jeffrey R. Curtis, Shilpa Venkatachalam and Monika M. Safford

    Citation: BMC Rheumatology 2020 4:26

    Content type: Research article

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  3. Osteoarthritis (OA) is a progressive, chronic disease characterized by articular cartilage destruction. The pro-inflammatory cytokine IL-17 levels have been reported elevated in serum and synovial fluid of OA ...

    Authors: Dovile Sinkeviciute, Anders Aspberg, Yi He, Anne-Christine Bay-Jensen and Patrik Önnerfjord

    Citation: BMC Rheumatology 2020 4:30

    Content type: Research article

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  4. The pathophysiology of osteoarthritis (OA) involves wear and tear, and a state of low-grade inflammation. Tissue repair responses include transforming growth factor beta (TGFβ)-induced myofibroblast production...

    Authors: Tue W. Kragstrup, Dong H. Sohn, Christin M. Lepus, Kazuhiro Onuma, Qian Wang, William H. Robinson and Jeremy Sokolove

    Citation: BMC Rheumatology 2019 3:46

    Content type: Research article

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  5. The objective of this study was to explore the associations between ultrasonographic and radiographic joint scores and levels of arterial CVD risk markers in patients with osteoarthritis (OA). Secondly, to com...

    Authors: S. A. Provan, S. Rollefstad, E. Ikdahl, A. Mathiessen, I. J. Berg, I. Eeg, I. B. Wilkinson, C. M. McEniery, T. K. Kvien, H. B. Hammer, N. Østerås, I. K. Haugen and A. G. Semb

    Citation: BMC Rheumatology 2019 3:33

    Content type: Research article

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  6. Anti-neutrophil cytoplasmic antibodies associated vasculitides (AAV) are characterized by autoimmune small vessel inflammation. Eosinophils are multifunctional cells with both pro-inflammatory and immunoregula...

    Authors: Thomas Hellmark, Sophie Ohlsson, Åsa Pettersson, Markus Hansson and Åsa C. M. Johansson

    Citation: BMC Rheumatology 2019 3:9

    Content type: Research article

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  7. To understand the roles of serum exosomes in rheumatoid arthritis (RA), we comprehensively investigated the protein profiles of serum exosomes in patients with RA.

    Authors: Hirotaka Tsuno, Mitsumi Arito, Naoya Suematsu, Toshiyuki Sato, Atsushi Hashimoto, Toshihiro Matsui, Kazuki Omoteyama, Masaaki Sato, Kazuki Okamoto, Shigeto Tohma, Manae S. Kurokawa and Tomohiro Kato

    Citation: BMC Rheumatology 2018 2:35

    Content type: Research article

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  8. The pathogenesis of spondyloarthritis (SpA) involves both inflammation and new bone formation in the spine. In line with this, the disease has been characterized as both inflammatory and fibrotic. The current ...

    Authors: Julie Stougaard, Søren Lomholt, Pernille Ommen, Jens Kelsen and Tue W. Kragstrup

    Citation: BMC Rheumatology 2018 2:33

    Content type: Research article

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  9. Resveratrol is a natural polyphenol found in berries, roots and wine that is well known to have anti-inflammatory and anti-oxidative properties. The anti-inflammatory effect has been reported for both immune c...

    Authors: S. Lomholt, A. Mellemkjaer, M. B. Iversen, S. B. Pedersen and T. W. Kragstrup

    Citation: BMC Rheumatology 2018 2:27

    Content type: Research article

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  10. Vitamin D has been implicated as being involved in the aetio-pathogenesis of several autoimmune diseases including rheumatoid arthritis (RA). Previous studies present contradictory results. Vitamin D binding p...

    Authors: Mikael Brink, Linda Johansson, Evelina Nygren, Lisbeth Ärlestig, Johan Hultdin and Solbritt Rantapää-Dahlqvist

    Citation: BMC Rheumatology 2018 2:26

    Content type: Research article

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  11. Anti-cytokine therapies such as adalimumab, tocilizumab, and the small molecule JAK inhibitor tofacitinib have proven that cytokines and their subsequent downstream signaling processes are important in the pat...

    Authors: Julie M. Parmentier, Jeff Voss, Candace Graff, Annette Schwartz, Maria Argiriadi, Michael Friedman, Heidi S. Camp, Robert J. Padley, Jonathan S. George, Deborah Hyland, Matthew Rosebraugh, Neil Wishart, Lisa Olson and Andrew J. Long

    Citation: BMC Rheumatology 2018 2:23

    Content type: Research article

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