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Pre-clinical and translational science

Section edited by Alessia Alunno (Perugia, Italy)

This section concerns all aspects of pre-clinical and translational research in rheumatology covering a wide range of methodologies and study designs, including the identification of the molecular underpinnings of disease and the application of this knowledge for the discovery of new drug targets or for patient stratification.

  1. Content type: Research article

    The objective of this study was to explore the associations between ultrasonographic and radiographic joint scores and levels of arterial CVD risk markers in patients with osteoarthritis (OA). Secondly, to com...

    Authors: S. A. Provan, S. Rollefstad, E. Ikdahl, A. Mathiessen, I. J. Berg, I. Eeg, I. B. Wilkinson, C. M. McEniery, T. K. Kvien, H. B. Hammer, N. Østerås, I. K. Haugen and A. G. Semb

    Citation: BMC Rheumatology 2019 3:33

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  2. Content type: Research article

    Anti-neutrophil cytoplasmic antibodies associated vasculitides (AAV) are characterized by autoimmune small vessel inflammation. Eosinophils are multifunctional cells with both pro-inflammatory and immunoregula...

    Authors: Thomas Hellmark, Sophie Ohlsson, Åsa Pettersson, Markus Hansson and Åsa C. M. Johansson

    Citation: BMC Rheumatology 2019 3:9

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  3. Content type: Research article

    To understand the roles of serum exosomes in rheumatoid arthritis (RA), we comprehensively investigated the protein profiles of serum exosomes in patients with RA.

    Authors: Hirotaka Tsuno, Mitsumi Arito, Naoya Suematsu, Toshiyuki Sato, Atsushi Hashimoto, Toshihiro Matsui, Kazuki Omoteyama, Masaaki Sato, Kazuki Okamoto, Shigeto Tohma, Manae S. Kurokawa and Tomohiro Kato

    Citation: BMC Rheumatology 2018 2:35

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  4. Content type: Research article

    The pathogenesis of spondyloarthritis (SpA) involves both inflammation and new bone formation in the spine. In line with this, the disease has been characterized as both inflammatory and fibrotic. The current ...

    Authors: Julie Stougaard, Søren Lomholt, Pernille Ommen, Jens Kelsen and Tue W. Kragstrup

    Citation: BMC Rheumatology 2018 2:33

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  5. Content type: Research article

    Resveratrol is a natural polyphenol found in berries, roots and wine that is well known to have anti-inflammatory and anti-oxidative properties. The anti-inflammatory effect has been reported for both immune c...

    Authors: S. Lomholt, A. Mellemkjaer, M. B. Iversen, S. B. Pedersen and T. W. Kragstrup

    Citation: BMC Rheumatology 2018 2:27

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  6. Content type: Research article

    Vitamin D has been implicated as being involved in the aetio-pathogenesis of several autoimmune diseases including rheumatoid arthritis (RA). Previous studies present contradictory results. Vitamin D binding p...

    Authors: Mikael Brink, Linda Johansson, Evelina Nygren, Lisbeth Ärlestig, Johan Hultdin and Solbritt Rantapää-Dahlqvist

    Citation: BMC Rheumatology 2018 2:26

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  7. Content type: Research article

    Anti-cytokine therapies such as adalimumab, tocilizumab, and the small molecule JAK inhibitor tofacitinib have proven that cytokines and their subsequent downstream signaling processes are important in the pat...

    Authors: Julie M. Parmentier, Jeff Voss, Candace Graff, Annette Schwartz, Maria Argiriadi, Michael Friedman, Heidi S. Camp, Robert J. Padley, Jonathan S. George, Deborah Hyland, Matthew Rosebraugh, Neil Wishart, Lisa Olson and Andrew J. Long

    Citation: BMC Rheumatology 2018 2:23

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