This section concerns all aspects of pre-clinical and translational research in rheumatology covering a wide range of methodologies and study designs, including the identification of the molecular underpinnings of disease and the application of this knowledge for the discovery of new drug targets or for patient stratification.
Characterization of the mechanism of action of lanraplenib, a novel spleen tyrosine kinase inhibitor, in models of lupus nephritis
B cells are critical mediators of systemic lupus erythematosus (SLE) and lupus nephritis (LN), and antinuclear antibodies can be found in the serum of approximately 98% of patients with SLE. Spleen tyrosine ki...
Citation: BMC Rheumatology 2021 5:15