Articles
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Citation: BMC Rheumatology 2022 6:72
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Exome sequencing can misread high variant allele fraction of somatic variants in UBA1 as hemizygous in VEXAS syndrome: a case report
VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic syndrome) is a recently described syndrome caused by a somatic missense variant at the methionine-41 (p.(Met41)) position in the ubiquit...
Citation: BMC Rheumatology 2022 6:54 -
The potential role of community pharmacy staff in reducing patient delay in consulting with symptoms of rheumatoid arthritis: a qualitative study
Rheumatoid arthritis (RA) is a chronic inflammatory arthritis which can cause joint damage and reduced quality of life. Early treatment of RA within 3 months of symptom onset is associated with improved clinic...
Citation: BMC Rheumatology 2022 6:50 -
Determinants of work and social participation in patients with psoriatic arthritis in the Netherlands: an observational study
Psoriatic arthritis can cause pain, disability, and permanent joint damage. This can lead to impairments in work and social participation. Little is known about the extent of these impairments in routine pract...
Citation: BMC Rheumatology 2022 6:49 -
Skin thickness affects the result of tuberculin skin test in systemic sclerosis
Skin thickness is a prominent clinical feature of systemic sclerosis (SSc), but there is no consensus on the cut-off for a positive tuberculin skin test (TST) size and the limitation of the TST for a diagnosis...
Citation: BMC Rheumatology 2022 6:48 -
Priorities for rheumatic and musculoskeletal disease research in Ireland
Research priority setting is a useful approach to decide which unanswered questions are most worth trying to solve through research. The aim is to reduce bias in the research agenda. Traditionally, research wa...
Citation: BMC Rheumatology 2022 6:55 -
Muscle B mode ultrasound and shear-wave elastography in idiopathic inflammatory myopathies (SWIM): criterion validation against MRI and muscle biopsy findings in an incident patient cohort
B mode ultrasound (US) and shear wave elastography (SWE) are easily accessible imaging tools for idiopathic inflammatory myopathies (IIM) but require further validation against standard diagnostic procedures s...
Citation: BMC Rheumatology 2022 6:47 -
(Dis)agreement of polymyalgia rheumatica relapse criteria, and prediction of relapse in a retrospective cohort
To develop and assess a prediction model for polymyalgia rheumatica (PMR) relapse within the first year of glucocorticoid (GC) treatment.
Citation: BMC Rheumatology 2022 6:45 -
Understanding beliefs related to physical activity in people living with axial Spondyloarthritis: a theory-informed qualitative study
People living with axial Spondyloarthrtis (axSpA) have an increased risk of cardiovascular diseases, which can be reduced by regular physical activity (PA) and its subset of cardiorespiratory training (CRT). T...
Citation: BMC Rheumatology 2022 6:40 -
Incidence, remission, and persistence of Raynaud’s phenomenon in the general population of northern Sweden: a prospective study
Raynaud’s phenomenon is common condition, but little is known about the natural course. The primary aim of this study was to determine the incidence, remission, and persistence proportions of Raynaud’s phenome...
Citation: BMC Rheumatology 2022 6:41 -
COVID-19 as a putative trigger of anti-MDA5-associated dermatomyositis with acute respiratory distress syndrome (ARDS) requiring lung transplantation, a case report
Autoimmune disease following COVID-19 has been studied intensely since the beginning of the pandemic. Growing evidence indicates that SARS-CoV-2 infection, by virtue of molecular mimicry can lead to an antigen...
Citation: BMC Rheumatology 2022 6:42 -
Serum S100A8/A9 concentrations are associated with neuropsychiatric involvement in systemic lupus erythematosus: a cross-sectional study
Neuropsychiatric (NP) involvement and fatigue are major problems in systemic lupus erythematosus (SLE). S100A8/A9 is a marker of inflammation and responds to therapy in SLE patients. S100A8/A9 has an immunopat...
Citation: BMC Rheumatology 2022 6:38 -
The Your Rheum story: involvement of young people in rheumatology research
Until recently, young people too often fell into the gaps between services due to restrictive age criteria. Furthermore, their voice was too infrequently heard or was represented by proxies in the form of thei...
Citation: BMC Rheumatology 2022 6:43 -
Whole exome sequencing in a juvenile idiopathic arthritis large family with SERPINA1 gene mutations
Although the underlying mechanisms and mediators of arthritis in juvenile idiopathic arthritis are not well understood, accumulated evidence supports the mixt role of genetic and environmental factors. Few rep...
Citation: BMC Rheumatology 2022 6:39 -
Malignancy in ankylosing spondylitis: a cross-sectional analysis of a large population database
Increased cancer-risk has been reported with rheumatoid arthritis and systemic lupus erythematosus, but the risk is poorly studied in ankylosing spondylitis (AS). Conflicting data in AS have been reported in A...
Citation: BMC Rheumatology 2022 6:44 -
The impact of consecutive COVID-19 lockdowns in England on mental wellbeing in people with inflammatory arthritis
During the first UK COVID-19 lockdown, studies identified over half of inflammatory arthritis (IA) patients in the UK reported a worsening of emotional distress. Given the prolonged nature of the pandemic, and...
Citation: BMC Rheumatology 2022 6:37 -
Development of an interdisciplinary early rheumatoid arthritis care pathway
To develop an interdisciplinary care pathway for early rheumatoid arthritis (RA) including referral triage, diagnosis, and management.
Citation: BMC Rheumatology 2022 6:35 -
A prospective longitudinal study evaluating the influence of immunosuppressives and other factors on COVID-19 in autoimmune rheumatic diseases
We conducted this study to identify the influence of prolonged use of hydroxychloroquine (HCQ), glucocorticoids and other immunosuppressants (IS) on occurrence and outcome of COVID-19 in patients with autoimmu...
Citation: BMC Rheumatology 2022 6:32 -
Effect of omega-three supplementation on serum urate and gout flares in people with gout; a pilot randomized trial
To determine the effect of omega-three supplementation with fish oil on serum urate, weight and body mass index (BMI) in people with gout.
Citation: BMC Rheumatology 2022 6:31 -
Skin model for improving the reliability of the modified Rodnan skin score for systemic sclerosis
The gold standard for skin thickness assessment in systemic sclerosis (SSc) is the modified Rodnan skin score (mRSS); however, inter- and intra-rater variation can arise due to subjective methods and inexperie...
Citation: BMC Rheumatology 2022 6:33 -
Effect of metformin use on clinical outcomes and serum urate in gout patients with diabetes mellitus: a retrospective cohort study
Gout and diabetes mellitus type 2 (DM) frequently co-exist. The pharmacological effects of metformin may include anti-inflammatory and urate lowering effects. The objective of this study was to test these effe...
Citation: BMC Rheumatology 2022 6:27 -
Evaluation of mindfulness based stress reduction in symptomatic knee or hip osteoarthritis patients: a pilot randomized controlled trial
To evaluate the efficacy for symptomatic knee and hip osteoarthritis (OA) patients of a mindfulness-based stress reduction (MBSR) program versus usual care.
Citation: BMC Rheumatology 2022 6:46 -
A combination of two or more unhealthy lifestyle factors is associated with impaired physical and mental health in patients with spondyloarthritis: a cross-sectional study
There is increasing knowledge of how individual lifestyle factors affect patients with spondyloarthritis, while studies exploring the combination of unhealthy lifestyle factors are lacking. Thus, our aim was t...
Citation: BMC Rheumatology 2022 6:29 -
Pharmacist knowledge of gout management: impact of an educational intervention
Pharmacists play a key role in community gout education. We investigated pharmacist knowledge of gout management and developed an educational intervention which was assessed in a cohort of Irish pharmacists.
Citation: BMC Rheumatology 2022 6:30 -
Raynaud’s phenomenon and positive antinuclear antibodies as first manifestation of POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes): a case report
POEMS syndrome is a rare paraneoplastic syndrome caused by plasma cell disorder almost always lambda restricted. Secondary Raynaud’s phenomenon is an overlooked skin manifestation of the disease even though it...
Citation: BMC Rheumatology 2022 6:26 -
Pharmacological use of gamma-aminobutyric acid derivatives in osteoarthritis pain management: a systematic review
Pain is the major complication of osteoarthritis (OA) patients and is a decisive symptom for medical intervention. Gamma-aminobutyric acid (GABA) derivatives are optional painkillers but not widely used in pai...
Citation: BMC Rheumatology 2022 6:28 -
Coding joint: kappa-deleting recombination excision circle ratio and B cell activating factor level: predicting juvenile dermatomyositis rituximab response, a proof-of-concept study
This pilot study’s primary aim was to determine if oligoclonal B cell expansion in children with Juvenile Dermatomyositis (JDM) predicts response to Rituximab therapy. We evaluated: (1) tissue B cell depletion...
Citation: BMC Rheumatology 2022 6:36 -
Validity and reliability of the Persian version of illness invalidation inventory (3*I) among patients with non-inflammatory rheumatic painful disorders
The Invalidation Illness Inventory (3*I) is an instrument that assesses invalidation (including discounting and lack of understanding dimensions) experienced by patients with rheumatic disorders. This study ai...
Citation: BMC Rheumatology 2022 6:23 -
TNF-α inhibitor induced pigmented purpuric dermatoses: a case report
We present a rare case of TNF-α inhibitor induced pigmented purpuric dermatoses (PPD) and explore its mechanisms and management.
Citation: BMC Rheumatology 2022 6:34 -
Circulating CTRP5 in rheumatoid arthritis: an exploratory biomarker study
Rheumatoid arthritis (RA) is an inflammatory disease that is characterized by the overproduction of cytokines. Among the newly discovered cytokines are the adipokines which are primarily produced by and releas...
Citation: BMC Rheumatology 2022 6:25 -
Cognitive performance in systemic lupus erythematosus patients: a cross-sectional and longitudinal study
Previous research has provided evidence for cognitive dysfunction as a common symptom of systemic lupus erythematosus (SLE). In light of this, the primary goal of this study was to investigate how cognitive im...
Citation: BMC Rheumatology 2022 6:22 -
Identification of poor prognostic joint locations in an early rheumatoid arthritis cohort at risk of rapidly progressing disease: a post-hoc analysis of the Phase III AGREE study
Rheumatoid arthritis (RA) is a heterogeneous disease with established poor prognostic factors such as seropositivity, joint damage, and high disease activity at an early, treatment-naïve stage of disease. Howe...
Citation: BMC Rheumatology 2022 6:24 -
Health-related quality of life and treatment satisfaction in Palestinians with rheumatoid arthritis: a cross-sectional study
Studying health-related quality of life (HRQoL) and treatment satisfaction have helped in understanding how to optimize rheumatoid arthritis (RA) treatment outcomes and find ways to alleviate signs and symptom...
Citation: BMC Rheumatology 2022 6:19 -
Dermatomyositis post vaccine against SARS-COV2
Dermatomyositis belongs to an infrequent group of diseases predominantly found in patients older than 40 years old and is characterized by dermal and muscular findings. This disease presents itself as proximal...
Citation: BMC Rheumatology 2022 6:20 -
Comparison of efficacy between triamcinolone acetonide and triamcinolone hexacetonide for intraarticular therapy in juvenile idiopathic arthritis: a retrospective analysis
There are many FDA-approved corticosteroid preparations available for intra-articular injection, however triamcinolone hexacetonide is not one of them. It was the intraarticular drug of choice among pediatric ...
Citation: BMC Rheumatology 2022 6:18 -
A “cat”-astrophic case of Bartonella infective endocarditis causing secondary cryoglobulinemia: a case report
Culture-negative infective endocarditis (IE) constitutes approximately 10% of all cases of IE. Bartonella endocarditis is a common cause of culture-negative endocarditis and is associated with a high mortality...
Citation: BMC Rheumatology 2022 6:16 -
Nemaline myopathy in newly diagnosed systemic lupus erythematosus and Sjögren’s overlap syndrome complicated by macrophage activation syndrome
Nemaline myopathies are congenital or acquired muscle disorders that typically present in childhood but can occasionally occur in adults with underlying malignant, infectious or autoimmune disorders. There is ...
Citation: BMC Rheumatology 2022 6:21 -
Psychometric properties of the PROMIS Preference score (PROPr) in patients with rheumatological and psychosomatic conditions
The PROMIS Preference score (PROPr) is a new generic preference-based health-related quality of life (HRQoL) score that can be used as a health state utility (HSU) score for quality-adjusted life years (QALYs)...
Citation: BMC Rheumatology 2022 6:15 -
Public perceptions of predictive testing for rheumatoid arthritis compared to breast cancer and early-onset Alzheimer’s disease: a qualitative study
There is increasing research focus on prediction and prevention of rheumatoid arthritis (RA). Information about risk of RA is increasingly available via direct-to-consumer testing. However, there is limited un...
Citation: BMC Rheumatology 2022 6:14 -
Empowering rare disease patients through patient education: the new BehçeTalk programme
Educating patients and caregivers on their disease can improve their knowledge and promote the active involvement in the therapeutic decision-making process. Naturally, patient education programmes are critica...
Citation: BMC Rheumatology 2022 6:17 -
Incidence and predictors of fragility fracture in postmenopausal rheumatoid arthritis patients receiving oral bisphosphonates: a longitudinal observational study
Although many studies have reported the predictors of fractures in patients with rheumatoid arthritis (RA) who are not receiving anti-osteoporotic treatments or who are receiving unspecified treatments, studie...
Citation: BMC Rheumatology 2022 6:8 -
Patients’ perspectives of telemedicine appointments for psoriatic arthritis during the COVID-19 pandemic: results of a patient-driven pilot survey
Over recent years the lack of patient involvement in the design, set-up and implementation of clinical research studies has been well recognised; as such there has been a drive within research communities to i...
Citation: BMC Rheumatology 2022 6:13 -
Myositis with prominent B-cell aggregates causing shrinking lung syndrome in systemic lupus erythematosus: a case report
Shrinking lung syndrome (SLS) is a rare manifestation of systemic lupus erythematosus (SLE) characterized by decreased lung volumes and diaphragmatic weakness in a dyspneic patient. Chest wall dysfunction seco...
Citation: BMC Rheumatology 2022 6:11 -
Predictive value of erythrocyte sedimentation rate and C-reactive protein in Behcet's disease activity and manifestations: a cross-sectional study
Behcet’s disease (BD) as a chronic inflammatory condition that affects the eyes, skin, central nervous system, gastrointestinal tract and vessels. According to the literature, the exact value of C-reactive pro...
Citation: BMC Rheumatology 2022 6:9 -
Small vessel vasculitis and dry gangrene secondary to combined CTLA-4 and PD-1 blockade in malignant mesothelioma
Malignant pleural mesothelioma (MPM) is a rare and aggressive tumour with an overall poor prognosis. In October 2020, first line treatment with the PD-1 antagonist nivolumab and the CTLA-4 antagonist ipilimuma...
Citation: BMC Rheumatology 2022 6:10 -
Depression and food insecurity among patients with rheumatoid arthritis in NHANES
Social determinants of health (SDH), including food insecurity, are associated with depression in the general population. This study estimated the prevalence of depression and food insecurity and evaluated the...
Citation: BMC Rheumatology 2022 6:6 -
Rapid monitoring of health services use following a policy to switch patients from originator to biosimilar etanercept—a cohort study in British Columbia
Drug coverage policies that incentivize switching patients from originator to biosimilar products may result in significant health care savings. Our study aimed to detect early impacts on health services utili...
Citation: BMC Rheumatology 2022 6:5 -
The burden of the most common rheumatic disease in Colombia
Estimating the burden of rheumatic diseases (RDs) requires proper evaluation of its lethal and nonlethal consequences. In Colombia, it is possible to find local data and Global Burden of Disease (GBD) reports ...
Citation: BMC Rheumatology 2022 6:7 -
Lessons learned from a pilot implementation of physical activity recommendations in axial spondyloarthritis exercise group therapy
The Ankylosing Spondylitis Association of Switzerland (SVMB) aimed to implement physical activity recommendations (PAR) within their exercise groups (EGs). The PAR promote exercise in all fitness dimensions at...
Citation: BMC Rheumatology 2022 6:12 -
Association of rheumatoid arthritis and its severity with human leukocytic antigen-DRB1 alleles in Kurdish region in North of Iraq
Rheumatoid arthritis is a complex multifactorial chronic disease, the importance of human leukocytic antigen (HLA) as a major genetic risk factor for rheumatoid arthritis was studied worldwide. The objective o...
Citation: BMC Rheumatology 2022 6:4
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