Table 4 Researcher-informed recommendations for developing a core domain set for interventional studies targeting medication adherence in rheumatology
Recommendation | CorrespondingTheme/Category |
|---|---|
1. Specify benefits and consequences to support informed use of the core domain set byadherence researchers | 3c |
2. Involve patients, clinicians, decision makers, and other stakeholders in developing a coredomain set to represent and reflect respective priorities | 3d |
3. Consider the following aspects when establishing a core domain set | |
-therapeutic area (e.g., clinical outcomes in rheumatology vary across conditions) | |
- culture of the target group (particularly when the experience with the intervention) | |
- research elements such as study objectives (pragmatic trials have different outcomes ofinterest than pilot studies) and study design (data source, data collection, analysis. | |
-logistical factors including feasibility and funding availability (whether researchers can affordto measure a certain outcome) | |
- the design of the intervention | |
4. Prioritize the following features of outcomes in a core domain set: | 3b |
-relevance (to the target patient population) | |
-feasibility (to implement, not cost-prohibitive) | |
-validity (have sound measurement properties) | |
5. Provide a complementary glossary for the core domain set to ensure consistent applicationand reporting | 3d |
6. Accompany the core domain set with guidelines to standardize measurement methods. | 3d |