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Table 1 Baseline characteristics for patients in the total cohort, with early and established RA

From: Osteoporosis-related fractures in men and women with established and early rheumatoid arthritis: predictors and risk compared with the general population

Total cohort

Men

Women

All

Number

527

1401

1928

Age (years) mean (SD)

60.5 (14.7)

59.5 (15.9)

59.8 (15.6)

RA duration at inclusion (years), median (IQR)

3 (0–14)

3 (0–14)

3 (0–14)

RA duration at first questionnaire (years), median (IQR)

7 (4–17)

7 (4–17)

7 (4–17)

RF-positive n (%)

322 (73.5)

855 (73.3)

1177 (73.3)

HAQ mean (SD)*

0.75 (0.68)

1.1 (0.76)

0.97 (0.75)

VAS pain (mm) mean (SD)*

37.9 (27.4)

44.5 (26.5)

42.7 (26.9)

VAS global health (mm) mean (SD)*

38.2 (26.4)

42.7 (26.2)

41.5 (26.3)

Methotrexate n (%)*

189 (46.1)

479 (43.0)

668 (43.9)

csDMARDs other than Methotrexate n (%)*

114 (27.8)

321 (28.8)

435 (28.6)

bDMARDs n (%)*

42 (10.2)

121 (10.9)

163 (10.7)

Prednisolone n (%)*

105 (25.6)

273 (24.5)

378 (24.8)

Previous osteoporosis-related fracture n (%)

13 (2.5)

81 (5.8)

94 (4.9)

Early RA

Men

Women

All

Number

211

527

738

Age (years) mean (SD)

57.9 (14.7)

55.4 (16.8)

56.1 (16.3)

RA duration at inclusion (years), median (IQR)

< 1 (< 1-<1)

< 1 (< 1-<1)

< 1 (< 1-<1)

RA duration at first questionnaire (years), median (IQR)

4 (2–5)

4 (2–5)

4 (2–5)

RF-positive n (%)

127 (67.7)

303 (66.3)

430 (66.7)

HAQ mean (SD)*

0.63 (0.59)

0.77 (0.57)

0.73 (0.58)

VAS pain (mm) mean (SD)*

37.3 (27.1)

40.1 (24.9)

39.4 (25.5)

VAS global health (mm) mean (SD)*

38.1 (26.6)

39.1 (24.4)

38.9 (25.0)

Methotrexate n (%)*

101 (67.3)

256 (62.6)

357 (63.9)

csDMARDs other than Methotrexate n (%)*

41 (27.3)

105 (25.7)

146 (26.1)

bDMARDs n (%)*

26 (17.3)

72 (17.6)

98 (17.5)

Prednisolone n (%)*

37 (24.7)

94 (23.0)

131 (23.4)

Previous osteoporosis-related fracture n (%)

1 (0.5)

12 (2.3)

13 (1.8)

Established RA¶¶

Men

Women

All

Number

237

638

875

Age (years) mean (SD)

64.1 (13.3)

63.4 (13.9)

63.6 (13.7)

RA duration at inclusion (years), median (IQR)

14 (9–22)

15 (9–26)

15 (9–25)

RA duration at first questionnaire (years), median (IQR)

18 (11–25)

18 (11–27)

18 (11–27)

RF-positive n (%)

141 (79.2)

402 (80.9)

543 (80.4)

HAQ mean (SD)*

0.96 (0.74)

1.35 (0.80)

1.24 (0.80)

VAS pain (mm) mean (SD)*

41.1 (27.7)

48.7 (27.2)

46.6 (27.6)

VAS global health (mm) mean (SD)*

41.3 (27.0)

46.5 (27.2)

45.0 (27.2)

Methotrexate n (%)*

62 (32.3)

157 (30.8)

219 (31.2)

csDMARDs other than Methotrexate n (%)*

52 (27.1)

149 (29.3)

201 (28.7)

bDMARDs n (%)*

13 (6.8)

38 (7.5)

51 (7.3)

Prednisolone n (%)*

56 (29.2)

130 (25.5)

186 (26.5)

Previous osteoporosis-related fracture n (%)

10 (4.2)

61 (9.6)

71 (8.1)

  1. *At the date of the first available questionnaire
  2. In the total cohort at least one questionnaire was answered by 1523 patients. Of these 10 were missing HAQ, 50 missing VAS pain and 52 missing VAS global health
  3. SD: Standard Deviation; IQR: Interquartile Range; RA: Rheumatoid Arthritis; RF: Rheumatoid Factor; HAQ: Health Assessment Questionnaire; VAS: Visual Analogue Scale; csDMARDs: conventional synthetic Disease-modifying Antirheumatic Drugs; bDMARDs: biologic Disease-modifying Antirheumatic Drugs
  4. ¶Early RA: newly diagnosed (within 1 year) patients in 1997 or later, with follow-up time maximal 10 years
  5. ¶¶Established RA: patients with RA diagnosis for ≥ 5 years at study start (1997)