Table 2 Cytokine levels in AxSpa patients according to ASDAS disease activity scores

Number of subjects

6

15

27

13

-

Age (years)

40 ± 11

39 ± 10

42 ± 10

38 ± 8

0.67

ESR (mm/hr)

10 [2–13]

8 [6–14]

20 [11–31]

41 [31–59]

< 0.01

CRP (mg/L)

2 [2–2]

2 [2–2]

2.4 [2-9.1]

36.2 [7.2–43]

< 0.01

Subfatin (ng/mL)

0.5 [0.4–1.8]

0.7 [0.4–1.1]

0.6 [0.5–0.9]

0.8 [0.4–1.4]

0.82

CTHRC1 (ng/mL)

55 [40–162]

65 [39–95]

55 [39–84]

51 [47–125]

0.98

CTRP3 (ng/mL)

1.7 [1.6-3]

2 [1.8–2.4]

1.9 [1.7–2.1]

1.9 [1.8-3]

0.81

CTRP6 (ng/mL)

0.9 [0.4–4.5]

1.9 [1.4–2.9]

2.1 [1.4–2.6]

2.22 [1.6–5.9]

0.48

IL-6 (pg/mL)

89 [69–232]

73[51–82]

71 [58–79]

69 [51–135]

0.45

IL-17 (pg/mL)

17 [15–60]

28 [19–45]

19 [15–33]

26 [21–55]

0.35

TNF-alpha (pg/mL)

110 [83–168]

98 [83–142]

96 [80–129]

106 [94–146}

0.96

BASDAI (0–10)

1.8 [1.7–2.8]

2.2 [1.6–3.2]

4.5 [2.8–5.6]

4.3 [2.8–6.4]

< 0.01

BASFI (0–10)

0 [0-0.6]

1 [0-3.1]

2.6 [1–5]

3.4 [2.4-7]

< 0.01

BASMI (0–10)

1 [0–2]

0 [0–2]

1 [0–4]

4 [0–7]

0.15

MASES (0–13)

1 [0–1]

0 [0–3]

2 [0–5]

0 [0–3]

0.64

ASDAS-CRP

1 [0.7-1]

1.9 [1.6-2]

2.6 [2.3-3]

3.9 [3.7–4.1]

< 0.01

ASDAS-ESH

1.2 [0.7–1.2]

1.8 [1.5–2.3]

2.9 [2.4–3.2]

3.8 [3.6–4.1]

< 0.01