Table 2 Overview of organising themes and subthemes

1) Attributes of predictive and preventive approaches

1. Type and performance characteristics of predictive tool

2. Availability of and evidence base for preventive approaches

3. Risks associated with treatment

4. Benefits of predictive tools and preventive treatments

2) Ethical and psychological concerns

1. Social consequences

2. Psychological consequences

3. Uncertainty

3) Implementation issues

1. Knowledge of prediction and prevention and training needs

2. Resources

3. HCP roles

4. Guidelines

5. Patient factors

4) Learning from management of other conditions

1. Knowledge of disease

2. Treatment

3. Guidelines and tools for other diseases

4. Risk communication