| Crude |  | Adjusted a | |
---|---|---|---|---|
Variables at inclusion | HR | 95% CI | HR | 95% CI |
Demographics and history | Â | Â | Â | Â |
Male sex | 2.14 | 1.32–3.49 | 2.21 | 1.35–3.63 |
Age (per year) | 1.08 | 1.06–1.11 | 1.08 | 1.05–1.11 |
Time to DMARD (per SD) b | 0.81 | 0.56–1.18 | 1.05 | 0.71–1.55 |
Traditional CVD risk factors | Â | Â | Â | Â |
Hypertension | 2.81 | 1.75–4.52 | 1.91 | 1.17–3.11 |
Diabetes | 3.74 | 1.78–7.86 | 1.39 | 0.64–3.01 |
Hyperlipidaemia | 1.38 | 0.50–3.78 | 0.73 | 0.26–2.06 |
BMI (per SD) b | 1.04 | 0.82–1.32 | 0.96 | 0.73–1.26 |
Cigarette smoking status | Â | Â | Â | Â |
Never smoking (reference) | 1.00 | Â | 1.00 | Â |
Current | 1.41 | 0.78–2.53 | 1.65 | 0.85–3.19 |
Previous | 1.33 | 0.73–2.40 | 0.95 | 0.50–1.83 |
Ever | 1.35 | 0.81–2.27 | 1.23 | 0.71–2.14 |
Baseline disease parameters | Â | Â | Â | Â |
RF positivity | 0.80 | 0.50–1.28 | 0.92 | 0.57–1.50 |
Anti-CCP positivity | 0.94 | 0.57–1.56 | 1.12 | 0.66–1.88 |
COMP (per SD) b | 1.45 | 1.17–1.80 | 1.32 | 1.00-1.74 |
COMP categories | Â | Â | Â | Â |
Below median (reference) | 1.00 | Â | 1.00 | Â |
3rd quartile | 1.94 | 1.05–3.57 | 1.06 | 0.55–2.04 |
4th quartile | 2.62 | 1.43–4.82 | 1.72 | 0.92–3.22 |
DAS28 (per SD) b | 1.07 | 0.84–1.35 | 0.95 | 0.75–1.21 |
Disease activity c | Â | Â | Â | Â |
Moderate/low (reference) | 1.00 | Â | 1.00 | Â |
High | 1.37 | 0.85–2.20 | 1.11 | 0.67–1.85 |
HAQ (per SD) b | 1.09 | 0.86–1.39 | 0.97 | 0.76–1.24 |
ESR (per SD) b | 1.30 | 1.05–1.61 | 1.08 | 0.86–1.35 |
CRP below median (reference) | 1.00 | Â | 1.00 | Â |
CRP above median (> 9 mg/l) | 2.02 | 1.25–3.28 | 1.12 | 0.68–1.83 |